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[Plasma concentration of selected neoplastic markers in persons occupationally exposed to arsenic and heavy metals].
Med Pr 2004; 55(4):313-20MP

Abstract

BACKGROUND

Industrial development increases the threat to human health caused by chemical contamination of the environment. Occupational neoplasms induced by exposure to carcinogenic factors present in workplaces are one of its effects. Heavy metals, especially arsenic, play an important role in this process. The aim of the study was to assess potential carcinogenic effects of arsenic and other heavy metals and the relation between their concentrations in organic fluids and the level of specific neoplastic markers, which might indicate the risk of the development of occupation-related neoplastic diseases.

MATERIALS AND METHODS

Over two years, 224 men employed in the "Legnica" Copper Foundry, Divisions of Furnace Charge Preparing and Metallurgy, were examined. Plasma and urine concentrations of some metals and neoplastic markers were measured. We analyzed a possible correlations between metals and markers concentrations.

RESULTS AND CONCLUSIONS

The study allowed to establish a strong positive correlation between urine arsenic concentration, blood cadmium concentration and some serum neoplastic markers (CEA, SCC-Ag, PSA). There was a distinct synergistic reaction between the levels of arsenic, cadmium and lead intoxication and the number of smoked cigarettes, so that smoking copper smelters exposed to these metals form a high cancer risk group. Significant positive correlation between blood lead concentration, free erythrocyte protoporphyrins and the level of arsenic in copper smelters might indicate the increased risk of late effects of intoxication in persons under combined exposure to these metals.

Authors+Show Affiliations

Z Katedry i Kliniki Chorób Wewnetrznych, Zawodowych i Nadciśnienia Tetniczego, Akademii Medycznej we Wrocławiu. szyman@mp.plNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

15620040

Citation

Szymańska-Chabowska, Anna, et al. "[Plasma Concentration of Selected Neoplastic Markers in Persons Occupationally Exposed to Arsenic and Heavy Metals]." Medycyna Pracy, vol. 55, no. 4, 2004, pp. 313-20.
Szymańska-Chabowska A, Antonowicz-Juchniewicz J, Andrzejak R. [Plasma concentration of selected neoplastic markers in persons occupationally exposed to arsenic and heavy metals]. Med Pr. 2004;55(4):313-20.
Szymańska-Chabowska, A., Antonowicz-Juchniewicz, J., & Andrzejak, R. (2004). [Plasma concentration of selected neoplastic markers in persons occupationally exposed to arsenic and heavy metals]. Medycyna Pracy, 55(4), pp. 313-20.
Szymańska-Chabowska A, Antonowicz-Juchniewicz J, Andrzejak R. [Plasma Concentration of Selected Neoplastic Markers in Persons Occupationally Exposed to Arsenic and Heavy Metals]. Med Pr. 2004;55(4):313-20. PubMed PMID: 15620040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Plasma concentration of selected neoplastic markers in persons occupationally exposed to arsenic and heavy metals]. AU - Szymańska-Chabowska,Anna, AU - Antonowicz-Juchniewicz,Jolanta, AU - Andrzejak,Ryszard, PY - 2004/12/29/pubmed PY - 2005/1/29/medline PY - 2004/12/29/entrez SP - 313 EP - 20 JF - Medycyna pracy JO - Med Pr VL - 55 IS - 4 N2 - BACKGROUND: Industrial development increases the threat to human health caused by chemical contamination of the environment. Occupational neoplasms induced by exposure to carcinogenic factors present in workplaces are one of its effects. Heavy metals, especially arsenic, play an important role in this process. The aim of the study was to assess potential carcinogenic effects of arsenic and other heavy metals and the relation between their concentrations in organic fluids and the level of specific neoplastic markers, which might indicate the risk of the development of occupation-related neoplastic diseases. MATERIALS AND METHODS: Over two years, 224 men employed in the "Legnica" Copper Foundry, Divisions of Furnace Charge Preparing and Metallurgy, were examined. Plasma and urine concentrations of some metals and neoplastic markers were measured. We analyzed a possible correlations between metals and markers concentrations. RESULTS AND CONCLUSIONS: The study allowed to establish a strong positive correlation between urine arsenic concentration, blood cadmium concentration and some serum neoplastic markers (CEA, SCC-Ag, PSA). There was a distinct synergistic reaction between the levels of arsenic, cadmium and lead intoxication and the number of smoked cigarettes, so that smoking copper smelters exposed to these metals form a high cancer risk group. Significant positive correlation between blood lead concentration, free erythrocyte protoporphyrins and the level of arsenic in copper smelters might indicate the increased risk of late effects of intoxication in persons under combined exposure to these metals. SN - 0465-5893 UR - https://www.unboundmedicine.com/medline/citation/15620040/[Plasma_concentration_of_selected_neoplastic_markers_in_persons_occupationally_exposed_to_arsenic_and_heavy_metals]_ L2 - https://medlineplus.gov/arsenic.html DB - PRIME DP - Unbound Medicine ER -