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Effects of zinc, copper, and selenium on placental cadmium transport.
Biol Trace Elem Res. 2004 Winter; 102(1-3):39-49.BT

Abstract

The objective of the present study was to evaluate the potential effects of zinc, copper, and selenium on placental cadmium transport. From November 2002 through January 2003, a total of 47 healthy pregnant women from Da-Ye City, Hubei Province in Central China participated in the study. Their age, parity, gestational age, pregnancy history, and lifestyle data were obtained by questionnaire interview. The placental, whole-blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS), whole-blood zinc was measured by flame atomic absorption spectrometry (F-AAS), whole-blood copper by ICP-MS, and selenium was by atomic fluorescence spectrophotometry (AFS). The cord blood cadmium concentration (0.020-1.48 microg/L) was significantly lower than in maternal blood (0.80-25.20 microg/L, p<0.01). The placental cadmium concentration was from 0.082 to 3.97 microg/g dry weight. Multiple linear regression analysis indicated that lower levels of maternal blood copper were significantly associated with higher cadmium concentrations in cord blood. Placental cadmium in women with lower levels of maternal blood zinc was significantly higher than in those with normal zinc levels. The placental cadmium level in women with lower whole-blood selenium was significantly lower than in subjects with normal selenium levels. It was concluded that the essential elements copper, selenium, and zinc might significantly affect placental cadmium transport.

Authors+Show Affiliations

Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, P. O. Box 71, 300192 Tianjin, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15621926

Citation

Zhang, Yali, et al. "Effects of Zinc, Copper, and Selenium On Placental Cadmium Transport." Biological Trace Element Research, vol. 102, no. 1-3, 2004, pp. 39-49.
Zhang Y, Zhao Y, Wang J, et al. Effects of zinc, copper, and selenium on placental cadmium transport. Biol Trace Elem Res. 2004;102(1-3):39-49.
Zhang, Y., Zhao, Y., Wang, J., Zhu, H., Liu, Q., Fan, Y., Wang, N., Liu, A., Liu, H., Ou-Yang, L., Zhao, J., & Fan, T. (2004). Effects of zinc, copper, and selenium on placental cadmium transport. Biological Trace Element Research, 102(1-3), 39-49.
Zhang Y, et al. Effects of Zinc, Copper, and Selenium On Placental Cadmium Transport. Biol Trace Elem Res. 2004;102(1-3):39-49. PubMed PMID: 15621926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of zinc, copper, and selenium on placental cadmium transport. AU - Zhang,Yali, AU - Zhao,Yongcheng, AU - Wang,Jixian, AU - Zhu,Hongda, AU - Liu,Qingfen, AU - Fan,Yaguang, AU - Wang,Naifen, AU - Liu,Aiping, AU - Liu,Husheng, AU - Ou-Yang,Li, AU - Zhao,Jinhui, AU - Fan,Tiqiang, PY - 2004/02/03/received PY - 2004/03/25/accepted PY - 2004/12/29/pubmed PY - 2005/6/23/medline PY - 2004/12/29/entrez SP - 39 EP - 49 JF - Biological trace element research JO - Biol Trace Elem Res VL - 102 IS - 1-3 N2 - The objective of the present study was to evaluate the potential effects of zinc, copper, and selenium on placental cadmium transport. From November 2002 through January 2003, a total of 47 healthy pregnant women from Da-Ye City, Hubei Province in Central China participated in the study. Their age, parity, gestational age, pregnancy history, and lifestyle data were obtained by questionnaire interview. The placental, whole-blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS), whole-blood zinc was measured by flame atomic absorption spectrometry (F-AAS), whole-blood copper by ICP-MS, and selenium was by atomic fluorescence spectrophotometry (AFS). The cord blood cadmium concentration (0.020-1.48 microg/L) was significantly lower than in maternal blood (0.80-25.20 microg/L, p<0.01). The placental cadmium concentration was from 0.082 to 3.97 microg/g dry weight. Multiple linear regression analysis indicated that lower levels of maternal blood copper were significantly associated with higher cadmium concentrations in cord blood. Placental cadmium in women with lower levels of maternal blood zinc was significantly higher than in those with normal zinc levels. The placental cadmium level in women with lower whole-blood selenium was significantly lower than in subjects with normal selenium levels. It was concluded that the essential elements copper, selenium, and zinc might significantly affect placental cadmium transport. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/15621926/Effects_of_zinc_copper_and_selenium_on_placental_cadmium_transport_ L2 - https://dx.doi.org/10.1385/BTER:102:1-3:039 DB - PRIME DP - Unbound Medicine ER -