Tags

Type your tag names separated by a space and hit enter

Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements.
Biol Trace Elem Res. 2004 Winter; 102(1-3):105-12.BT

Abstract

Alterations of the normal redox balance in mammals might be attributed to increases of plasma free-radical concentrations and/or a disruption of the protective mechanisms. These conditions lead to damage to cellular structure by the mechanism of lipoperoxidation, particularly in the liver, kidney, and central nervous system. In this study, the effect of general anesthesia on the oxidative metabolism of human plasma and erythrocytes was investigated. Forty-five patients undergoing anesthesia by using halothane, enflurane, or isoflurane were included in this study. Blood samples were taken preoperatively, the first hour, the first day, and the third day after the operation. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities and trace elements such as cofactor copper (Cu), zinc (Zn) and selenium (Se) levels were measured in plasma and red blood cells. Our results showed that halothane and enflurane administration increased the plasma GSH-Px activity and reduced zinc levels. In addition, they lowered SOD and GSH-Px activities and trace element levels on erythrocytes. Isoflurane had no effect on plasma antioxidant enzymes, but, similar to the others, isoflurane decreased the plasma zinc levels, erythrocyte SOD and GSH-Px activities and trace element levels.

Authors+Show Affiliations

Department of Emergency Medicine, Division of Anesthesiology, Gazi University Medical Faculty, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15621932

Citation

Türkan, Hülya, et al. "Effects of Halothane, Enflurane, and Isoflurane On Plasma and Erythrocyte Antioxidant Enzymes and Trace Elements." Biological Trace Element Research, vol. 102, no. 1-3, 2004, pp. 105-12.
Türkan H, Bukan N, Sayal A, et al. Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements. Biol Trace Elem Res. 2004;102(1-3):105-12.
Türkan, H., Bukan, N., Sayal, A., Aydin, A., & Bukan, M. H. (2004). Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements. Biological Trace Element Research, 102(1-3), 105-12.
Türkan H, et al. Effects of Halothane, Enflurane, and Isoflurane On Plasma and Erythrocyte Antioxidant Enzymes and Trace Elements. Biol Trace Elem Res. 2004;102(1-3):105-12. PubMed PMID: 15621932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements. AU - Türkan,Hülya, AU - Bukan,Neslihan, AU - Sayal,Ahmet, AU - Aydin,Ahmet, AU - Bukan,M Hakan, PY - 2004/04/01/received PY - 2004/05/03/revised PY - 2004/05/31/accepted PY - 2004/12/29/pubmed PY - 2005/6/23/medline PY - 2004/12/29/entrez SP - 105 EP - 12 JF - Biological trace element research JO - Biol Trace Elem Res VL - 102 IS - 1-3 N2 - Alterations of the normal redox balance in mammals might be attributed to increases of plasma free-radical concentrations and/or a disruption of the protective mechanisms. These conditions lead to damage to cellular structure by the mechanism of lipoperoxidation, particularly in the liver, kidney, and central nervous system. In this study, the effect of general anesthesia on the oxidative metabolism of human plasma and erythrocytes was investigated. Forty-five patients undergoing anesthesia by using halothane, enflurane, or isoflurane were included in this study. Blood samples were taken preoperatively, the first hour, the first day, and the third day after the operation. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities and trace elements such as cofactor copper (Cu), zinc (Zn) and selenium (Se) levels were measured in plasma and red blood cells. Our results showed that halothane and enflurane administration increased the plasma GSH-Px activity and reduced zinc levels. In addition, they lowered SOD and GSH-Px activities and trace element levels on erythrocytes. Isoflurane had no effect on plasma antioxidant enzymes, but, similar to the others, isoflurane decreased the plasma zinc levels, erythrocyte SOD and GSH-Px activities and trace element levels. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/15621932/Effects_of_halothane_enflurane_and_isoflurane_on_plasma_and_erythrocyte_antioxidant_enzymes_and_trace_elements_ DB - PRIME DP - Unbound Medicine ER -