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Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population.
J Gastroenterol. 2004 Dec; 39(12):1138-42.JG

Abstract

BACKGROUND

The goal of this study was to determine the importance of Helicobacter pylori CagA+, VacA+, and HLA-DQA1 alleles in a Mexican population with gastric cancer (GC).

METHODS

We studied a group of Mexican patients (cases) with distal GC (n=22) or high-grade dysplasia (HGD; n=8) (mean age, 62.7 years, F : M=0.3; age range, 33-84 years) and 77 ethnically matched non-GC controls (mean age, 47.1 years; F : M=1.96; age range, 17-92 years). Both cases and controls were H. pylori-positive by at least two of the following diagnostic tests: rapid urease test, histology, culture, or serology. The presence of antibodies to CagA and VacA proteins was determined by Western blot, and the HLA-DQA1 typing was carried out by a polymerase chain reaction (PCR) sequence-specific primer method.

RESULTS

The carriage of H. pylori CagA+, VacA+ strains was associated with GC or HGD (odds ratio [OR], 6.07; 95% confidence interval [CI], 1.56-27.57; P=0.005). The allele frequency of DQA1*0503 was significantly lower in the GC-HGD group than in the non-GC group (OR, 0.13; 95% CI, 0.02-0.59). Logistic regression analysis identified the carriage of HLA-DQA1*0503 as an independent protective factor for GC (OR, 0.19; 95% CI, 0.04-0.94) and colonization with H. pylori CagA+, VacA+ strains as an independent risk factor for GC (OR, 6.15; 95% CI, 1.69-22.37).

CONCLUSIONS

Infection with H. pylori CagA+, VacA+ strains represents a significant risk for the development of GC. The absence of HLA-DQA1*0503 could be a host risk factor for the development of GC in Mexican patients.

Authors+Show Affiliations

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Nuevo León, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15622476

Citation

Garza-González, Elvira, et al. "Association of Gastric Cancer, HLA-DQA1, and Infection With Helicobacter Pylori CagA+ and VacA+ in a Mexican Population." Journal of Gastroenterology, vol. 39, no. 12, 2004, pp. 1138-42.
Garza-González E, Bosques-Padilla FJ, Pérez-Pérez GI, et al. Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population. J Gastroenterol. 2004;39(12):1138-42.
Garza-González, E., Bosques-Padilla, F. J., Pérez-Pérez, G. I., Flores-Gutiérrez, J. P., & Tijerina-Menchaca, R. (2004). Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population. Journal of Gastroenterology, 39(12), 1138-42.
Garza-González E, et al. Association of Gastric Cancer, HLA-DQA1, and Infection With Helicobacter Pylori CagA+ and VacA+ in a Mexican Population. J Gastroenterol. 2004;39(12):1138-42. PubMed PMID: 15622476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of gastric cancer, HLA-DQA1, and infection with Helicobacter pylori CagA+ and VacA+ in a Mexican population. AU - Garza-González,Elvira, AU - Bosques-Padilla,Francisco J, AU - Pérez-Pérez,Guillermo I, AU - Flores-Gutiérrez,Juan Pablo, AU - Tijerina-Menchaca,Rolando, PY - 2003/12/02/received PY - 2004/03/26/accepted PY - 2004/12/29/pubmed PY - 2005/4/6/medline PY - 2004/12/29/entrez SP - 1138 EP - 42 JF - Journal of gastroenterology JO - J Gastroenterol VL - 39 IS - 12 N2 - BACKGROUND: The goal of this study was to determine the importance of Helicobacter pylori CagA+, VacA+, and HLA-DQA1 alleles in a Mexican population with gastric cancer (GC). METHODS: We studied a group of Mexican patients (cases) with distal GC (n=22) or high-grade dysplasia (HGD; n=8) (mean age, 62.7 years, F : M=0.3; age range, 33-84 years) and 77 ethnically matched non-GC controls (mean age, 47.1 years; F : M=1.96; age range, 17-92 years). Both cases and controls were H. pylori-positive by at least two of the following diagnostic tests: rapid urease test, histology, culture, or serology. The presence of antibodies to CagA and VacA proteins was determined by Western blot, and the HLA-DQA1 typing was carried out by a polymerase chain reaction (PCR) sequence-specific primer method. RESULTS: The carriage of H. pylori CagA+, VacA+ strains was associated with GC or HGD (odds ratio [OR], 6.07; 95% confidence interval [CI], 1.56-27.57; P=0.005). The allele frequency of DQA1*0503 was significantly lower in the GC-HGD group than in the non-GC group (OR, 0.13; 95% CI, 0.02-0.59). Logistic regression analysis identified the carriage of HLA-DQA1*0503 as an independent protective factor for GC (OR, 0.19; 95% CI, 0.04-0.94) and colonization with H. pylori CagA+, VacA+ strains as an independent risk factor for GC (OR, 6.15; 95% CI, 1.69-22.37). CONCLUSIONS: Infection with H. pylori CagA+, VacA+ strains represents a significant risk for the development of GC. The absence of HLA-DQA1*0503 could be a host risk factor for the development of GC in Mexican patients. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/15622476/Association_of_gastric_cancer_HLA_DQA1_and_infection_with_Helicobacter_pylori_CagA+_and_VacA+_in_a_Mexican_population_ L2 - https://dx.doi.org/10.1007/s00535-004-1462-2 DB - PRIME DP - Unbound Medicine ER -