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The topical isoflavonoid NV-07alpha reduces solar-simulated UV-induced suppression of Mantoux reactions in humans.
Photochem Photobiol. 2004 Nov-Dec; 80(3):416-21.PP

Abstract

UV radiation suppresses delayed-type hypersensitivity responses to intradermally injected tuberculin purified protein derivative in Mantoux-positive individuals. The effect of the topically administered isoflavonoid NV-07alpha, a synthetic derivative of the isoflavonoid equol, on UV-induced suppression of Mantoux reactions was assessed in 18 healthy Mantoux-positive volunteers. A single, fixed dose of solar-simulated UV radiation was delivered to the volunteers' lower backs. Different concentrations of NV-07alpha or its vehicle were applied to different sites within the irradiated field immediately after UV exposure and again 24 h later. Forty-eight hours after irradiation, Mantoux testing was performed at both the irradiated sites and adjacent, unirradiated sites. The intensity of Mantoux reactions was measured 72 h later with a reflectance erythema meter and by measuring the diameter of each reaction. Although lower concentrations of NV-07alpha (0.5 and 2 mM) did not prevent UV immunosuppression, 4 mM NV-07alpha partially but significantly attenuated UV-induced suppression of Mantoux-induced erythema. Minimal erythema doses were also determined for sites treated with NV-07alpha or its vehicle immediately after UV exposure. NV-07alpha had no significant effects on UV erythema. We conclude that 4 mM NV-07alpha prevented the suppressive effects of UV radiation on Mantoux responses in humans but did not affect UV-induced erythema at the concentrations used.

Authors+Show Affiliations

Friedmann AC
Dermatology, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, New South Wales, Australia.
Halliday GM
No affiliation info available
Barnetson RS
No affiliation info available
Reeve VE
No affiliation info available
Walker C
No affiliation info available
Patterson CR
No affiliation info available
Damian DL
No affiliation info available

MeSH

Administration, TopicalAdultDose-Response Relationship, DrugEquolErythemaFemaleHumansIsoflavonesMaleMiddle AgedSkinUltraviolet Rays

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15623323

Citation

Friedmann, Adam C., et al. "The Topical Isoflavonoid NV-07alpha Reduces Solar-simulated UV-induced Suppression of Mantoux Reactions in Humans." Photochemistry and Photobiology, vol. 80, no. 3, 2004, pp. 416-21.
Friedmann AC, Halliday GM, Barnetson RS, et al. The topical isoflavonoid NV-07alpha reduces solar-simulated UV-induced suppression of Mantoux reactions in humans. Photochem Photobiol. 2004;80(3):416-21.
Friedmann, A. C., Halliday, G. M., Barnetson, R. S., Reeve, V. E., Walker, C., Patterson, C. R., & Damian, D. L. (2004). The topical isoflavonoid NV-07alpha reduces solar-simulated UV-induced suppression of Mantoux reactions in humans. Photochemistry and Photobiology, 80(3), 416-21.
Friedmann AC, et al. The Topical Isoflavonoid NV-07alpha Reduces Solar-simulated UV-induced Suppression of Mantoux Reactions in Humans. Photochem Photobiol. 2004 Nov-Dec;80(3):416-21. PubMed PMID: 15623323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The topical isoflavonoid NV-07alpha reduces solar-simulated UV-induced suppression of Mantoux reactions in humans. AU - Friedmann,Adam C, AU - Halliday,Gary M, AU - Barnetson,Ross StC, AU - Reeve,Vivienne E, AU - Walker,Catherine, AU - Patterson,Clare R S, AU - Damian,Diona L, PY - 2004/12/30/pubmed PY - 2006/12/9/medline PY - 2004/12/30/entrez SP - 416 EP - 21 JF - Photochemistry and photobiology JO - Photochem Photobiol VL - 80 IS - 3 N2 - UV radiation suppresses delayed-type hypersensitivity responses to intradermally injected tuberculin purified protein derivative in Mantoux-positive individuals. The effect of the topically administered isoflavonoid NV-07alpha, a synthetic derivative of the isoflavonoid equol, on UV-induced suppression of Mantoux reactions was assessed in 18 healthy Mantoux-positive volunteers. A single, fixed dose of solar-simulated UV radiation was delivered to the volunteers' lower backs. Different concentrations of NV-07alpha or its vehicle were applied to different sites within the irradiated field immediately after UV exposure and again 24 h later. Forty-eight hours after irradiation, Mantoux testing was performed at both the irradiated sites and adjacent, unirradiated sites. The intensity of Mantoux reactions was measured 72 h later with a reflectance erythema meter and by measuring the diameter of each reaction. Although lower concentrations of NV-07alpha (0.5 and 2 mM) did not prevent UV immunosuppression, 4 mM NV-07alpha partially but significantly attenuated UV-induced suppression of Mantoux-induced erythema. Minimal erythema doses were also determined for sites treated with NV-07alpha or its vehicle immediately after UV exposure. NV-07alpha had no significant effects on UV erythema. We conclude that 4 mM NV-07alpha prevented the suppressive effects of UV radiation on Mantoux responses in humans but did not affect UV-induced erythema at the concentrations used. SN - 0031-8655 UR - https://www.unboundmedicine.com/medline/citation/15623323/The_topical_isoflavonoid_NV_07alpha_reduces_solar_simulated_UV_induced_suppression_of_Mantoux_reactions_in_humans_ DB - PRIME DP - Unbound Medicine ER -