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Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract.
Photochem Photobiol. 2005 May-Jun; 81(3):581-7.PP

Abstract

Biochemical and structural changes of the dermal connective tissue substantially contribute to the phenotype of aging skin. To study connective tissue metabolism with respect to ultraviolet (UV) exposure, we performed an in vitro (human dermal fibroblasts) and an in vivo complementary DNA array study in combination with protein analysis in young and old volunteers. Several genes of the collagen metabolism such as Collagen I, III and VI as well as heat shock protein 47 and matrix metalloproteinase-1 are expressed differentially, indicating UV-mediated effects on collagen expression, processing and degradation. In particular, Collagen I is time and age dependently reduced after a single UV exposure in human skin in vivo. Moreover, older subjects display a lower baseline level and a shorter UV-mediated increase in hyaluronan (HA) levels. To counteract these age-dependent changes, cultured fibroblasts were treated with a specific soy extract. This treatment resulted in increased collagen and HA synthesis. In a placebo-controlled in vivo study, topical application of an isoflavone-containing emulsion significantly enhanced the number of dermal papillae per area after 2 weeks. Because the flattening of the dermal-epidermal junction is the most reproducible structural change in aged skin, this soy extract appears to rejuvenate the structure of mature skin.

Authors+Show Affiliations

Beiersdorf AG, Paul Gerson Unna Skin Research Center, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15623355

Citation

Südel, Kirstin M., et al. "Novel Aspects of Intrinsic and Extrinsic Aging of Human Skin: Beneficial Effects of Soy Extract." Photochemistry and Photobiology, vol. 81, no. 3, 2005, pp. 581-7.
Südel KM, Venzke K, Mielke H, et al. Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem Photobiol. 2005;81(3):581-7.
Südel, K. M., Venzke, K., Mielke, H., Breitenbach, U., Mundt, C., Jaspers, S., Koop, U., Sauermann, K., Knussman-Hartig, E., Moll, I., Gercken, G., Young, A. R., Stäb, F., Wenck, H., & Gallinat, S. (2005). Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochemistry and Photobiology, 81(3), 581-7.
Südel KM, et al. Novel Aspects of Intrinsic and Extrinsic Aging of Human Skin: Beneficial Effects of Soy Extract. Photochem Photobiol. 2005 May-Jun;81(3):581-7. PubMed PMID: 15623355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. AU - Südel,Kirstin M, AU - Venzke,Kirsten, AU - Mielke,Heiko, AU - Breitenbach,Ute, AU - Mundt,Claudia, AU - Jaspers,Sören, AU - Koop,Urte, AU - Sauermann,Kirsten, AU - Knussman-Hartig,Elke, AU - Moll,Ingrid, AU - Gercken,Günther, AU - Young,Anthony R, AU - Stäb,Franz, AU - Wenck,Horst, AU - Gallinat,Stefan, PY - 2004/12/30/pubmed PY - 2005/10/4/medline PY - 2004/12/30/entrez SP - 581 EP - 7 JF - Photochemistry and photobiology JO - Photochem. Photobiol. VL - 81 IS - 3 N2 - Biochemical and structural changes of the dermal connective tissue substantially contribute to the phenotype of aging skin. To study connective tissue metabolism with respect to ultraviolet (UV) exposure, we performed an in vitro (human dermal fibroblasts) and an in vivo complementary DNA array study in combination with protein analysis in young and old volunteers. Several genes of the collagen metabolism such as Collagen I, III and VI as well as heat shock protein 47 and matrix metalloproteinase-1 are expressed differentially, indicating UV-mediated effects on collagen expression, processing and degradation. In particular, Collagen I is time and age dependently reduced after a single UV exposure in human skin in vivo. Moreover, older subjects display a lower baseline level and a shorter UV-mediated increase in hyaluronan (HA) levels. To counteract these age-dependent changes, cultured fibroblasts were treated with a specific soy extract. This treatment resulted in increased collagen and HA synthesis. In a placebo-controlled in vivo study, topical application of an isoflavone-containing emulsion significantly enhanced the number of dermal papillae per area after 2 weeks. Because the flattening of the dermal-epidermal junction is the most reproducible structural change in aged skin, this soy extract appears to rejuvenate the structure of mature skin. SN - 0031-8655 UR - https://www.unboundmedicine.com/medline/citation/15623355/Novel_aspects_of_intrinsic_and_extrinsic_aging_of_human_skin:_beneficial_effects_of_soy_extract_ L2 - https://doi.org/10.1562/2004-06-16-RA-202 DB - PRIME DP - Unbound Medicine ER -