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Petasites hybridus root (butterbur) is an effective preventive treatment for migraine.

Abstract

OBJECTIVE

To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine.

METHODS

This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine. Eligible patients met International Headache Society criteria for migraine, were ages 18 to 65, and had at least two to six attacks per month over the preceding 3 months. The main outcome measure was the decrease in migraine attack frequency per month calculated as percentage change from baseline over a 4-month treatment period.

RESULTS

Over 4 months of treatment, in the per-protocol analysis, migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), and 26% for the placebo group. The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05). Results were also significant in favor of Petasites 75 mg at 1, 2, and 3 months based on this endpoint. The most frequently reported adverse reactions considered possibly related to treatment were mild gastrointestinal events, predominantly burping.

CONCLUSIONS

Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine. Petasites 50 mg PO bid was not significantly more effective than placebo on the primary study endpoints.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Albert Einstein College of Medicine, 1165 Morris Park Ave., Rousso Bldg., Rm. 332, Bronx, NY 10461, USA. rlipton@aecom.yu.edu

    , , ,

    Source

    Neurology 63:12 2004 Dec 28 pg 2240-4

    MeSH

    Adult
    Asteraceae
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Migraine Disorders
    Phytotherapy
    Plant Extracts
    Plant Roots
    Sesquiterpenes
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    15623680

    Citation

    Lipton, R B., et al. "Petasites Hybridus Root (butterbur) Is an Effective Preventive Treatment for Migraine." Neurology, vol. 63, no. 12, 2004, pp. 2240-4.
    Lipton RB, Göbel H, Einhäupl KM, et al. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology. 2004;63(12):2240-4.
    Lipton, R. B., Göbel, H., Einhäupl, K. M., Wilks, K., & Mauskop, A. (2004). Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology, 63(12), pp. 2240-4.
    Lipton RB, et al. Petasites Hybridus Root (butterbur) Is an Effective Preventive Treatment for Migraine. Neurology. 2004 Dec 28;63(12):2240-4. PubMed PMID: 15623680.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. AU - Lipton,R B, AU - Göbel,H, AU - Einhäupl,K M, AU - Wilks,K, AU - Mauskop,A, PY - 2004/12/30/pubmed PY - 2005/8/16/medline PY - 2004/12/30/entrez SP - 2240 EP - 4 JF - Neurology JO - Neurology VL - 63 IS - 12 N2 - OBJECTIVE: To evaluate the clinical efficacy of a standardized special root extract from the plant Petasites hybridus as a preventive therapy for migraine. METHODS: This is a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine. Eligible patients met International Headache Society criteria for migraine, were ages 18 to 65, and had at least two to six attacks per month over the preceding 3 months. The main outcome measure was the decrease in migraine attack frequency per month calculated as percentage change from baseline over a 4-month treatment period. RESULTS: Over 4 months of treatment, in the per-protocol analysis, migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), and 26% for the placebo group. The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05). Results were also significant in favor of Petasites 75 mg at 1, 2, and 3 months based on this endpoint. The most frequently reported adverse reactions considered possibly related to treatment were mild gastrointestinal events, predominantly burping. CONCLUSIONS: Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine. Petasites 50 mg PO bid was not significantly more effective than placebo on the primary study endpoints. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15623680/full_citation L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=15623680 DB - PRIME DP - Unbound Medicine ER -