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Effects of epidural naloxone on pruritus induced by epidural morphine: a randomized controlled trial.
Int J Obstet Anesth. 2005 Jan; 14(1):22-5.IJ

Abstract

BACKGROUND

Epidural morphine produces prolonged analgesia but has many side effects including pruritus. Naloxone is an antagonist that can reverse the side effects of morphine.

METHOD

We studied the effects of continuously administered epidural naloxone mixed with morphine on side effects and analgesia in a randomized, double blind, two-armed study. Fifty-eight pregnant women undergoing cesarean section were enrolled. All patients received a 4-mg epidural bolus of morphine in the post-anesthetic care unit. After this, patients in group M (n=28) received continuous epidural morphine (6 mg over 48 h) in 0.1% bupivacaine; patients in group N (n=30) received an epidural infusion containing naloxone (1.2 mg over 48 h) and morphine (6 mg over 48 h) in 0.1% bupivacaine. The infusion rate was 2 mL/h.

RESULTS

The incidence (82% versus 47%) and severity of pruritus were lower in group N than group M (P=0.001). There were no significant differences in pain score or in the incidence of nausea, vomiting or urinary disturbance between groups.

CONCLUSION

Continuous epidural infusion of naloxone combined with morphine is effective in reducing the incidence and severity of pruritus induced by epidural morphine.

Authors+Show Affiliations

Jeon Y
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Hwang J
No affiliation info available
Kang J
No affiliation info available
Han S
No affiliation info available
Rhee K
No affiliation info available
Oh Y
No affiliation info available

MeSH

AdultAnalgesia, EpiduralDouble-Blind MethodFemaleHumansIncidenceMorphineNaloxoneNarcotic AntagonistsPostoperative Nausea and VomitingPregnancyPruritus

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15627534

Citation

Jeon, Y, et al. "Effects of Epidural Naloxone On Pruritus Induced By Epidural Morphine: a Randomized Controlled Trial." International Journal of Obstetric Anesthesia, vol. 14, no. 1, 2005, pp. 22-5.
Jeon Y, Hwang J, Kang J, et al. Effects of epidural naloxone on pruritus induced by epidural morphine: a randomized controlled trial. Int J Obstet Anesth. 2005;14(1):22-5.
Jeon, Y., Hwang, J., Kang, J., Han, S., Rhee, K., & Oh, Y. (2005). Effects of epidural naloxone on pruritus induced by epidural morphine: a randomized controlled trial. International Journal of Obstetric Anesthesia, 14(1), 22-5.
Jeon Y, et al. Effects of Epidural Naloxone On Pruritus Induced By Epidural Morphine: a Randomized Controlled Trial. Int J Obstet Anesth. 2005;14(1):22-5. PubMed PMID: 15627534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of epidural naloxone on pruritus induced by epidural morphine: a randomized controlled trial. AU - Jeon,Y, AU - Hwang,J, AU - Kang,J, AU - Han,S, AU - Rhee,K, AU - Oh,Y, PY - 2004/06/01/accepted PY - 2005/1/4/pubmed PY - 2005/3/18/medline PY - 2005/1/4/entrez SP - 22 EP - 5 JF - International journal of obstetric anesthesia JO - Int J Obstet Anesth VL - 14 IS - 1 N2 - BACKGROUND: Epidural morphine produces prolonged analgesia but has many side effects including pruritus. Naloxone is an antagonist that can reverse the side effects of morphine. METHOD: We studied the effects of continuously administered epidural naloxone mixed with morphine on side effects and analgesia in a randomized, double blind, two-armed study. Fifty-eight pregnant women undergoing cesarean section were enrolled. All patients received a 4-mg epidural bolus of morphine in the post-anesthetic care unit. After this, patients in group M (n=28) received continuous epidural morphine (6 mg over 48 h) in 0.1% bupivacaine; patients in group N (n=30) received an epidural infusion containing naloxone (1.2 mg over 48 h) and morphine (6 mg over 48 h) in 0.1% bupivacaine. The infusion rate was 2 mL/h. RESULTS: The incidence (82% versus 47%) and severity of pruritus were lower in group N than group M (P=0.001). There were no significant differences in pain score or in the incidence of nausea, vomiting or urinary disturbance between groups. CONCLUSION: Continuous epidural infusion of naloxone combined with morphine is effective in reducing the incidence and severity of pruritus induced by epidural morphine. SN - 0959-289X UR - https://www.unboundmedicine.com/medline/citation/15627534/Effects_of_epidural_naloxone_on_pruritus_induced_by_epidural_morphine:_a_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -