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Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Genomics Proteomics Bioinformatics. 2003 Nov; 1(4):247-62.GP

Abstract

The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information.

Authors+Show Affiliations

Department of Zoology, The University of Hong Kong, Hong Kong SAR, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15629054

Citation

Chow, Ken Yan Ching, et al. "Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV)." Genomics, Proteomics & Bioinformatics, vol. 1, no. 4, 2003, pp. 247-62.
Chow KY, Hon CC, Hui RK, et al. Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Genomics Proteomics Bioinformatics. 2003;1(4):247-62.
Chow, K. Y., Hon, C. C., Hui, R. K., Wong, R. T., Yip, C. W., Zeng, F., & Leung, F. C. (2003). Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Genomics, Proteomics & Bioinformatics, 1(4), 247-62.
Chow KY, et al. Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV). Genomics Proteomics Bioinformatics. 2003;1(4):247-62. PubMed PMID: 15629054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular advances in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). AU - Chow,Ken Yan Ching, AU - Hon,Chung Chau, AU - Hui,Raymond Kin Hi, AU - Wong,Raymond Tsz Yeung, AU - Yip,Chi Wai, AU - Zeng,Fanya, AU - Leung,Frederick Chi Ching, PY - 2005/1/5/pubmed PY - 2005/2/19/medline PY - 2005/1/5/entrez SP - 247 EP - 62 JF - Genomics, proteomics & bioinformatics JO - Genomics Proteomics Bioinformatics VL - 1 IS - 4 N2 - The sudden outbreak of severe acute respiratory syndrome (SARS) in 2002 prompted the establishment of a global scientific network subsuming most of the traditional rivalries in the competitive field of virology. Within months of the SARS outbreak, collaborative work revealed the identity of the disastrous pathogen as SARS-associated coronavirus (SARS-CoV). However, although the rapid identification of the agent represented an important breakthrough, our understanding of the deadly virus remains limited. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the SARS-CoV. This article reviews the present state of molecular knowledge about SARS-CoV, from the aspects of comparative genomics, molecular biology of viral genes, evolution, and epidemiology, and describes the diagnostic tests and the anti-viral drugs derived so far based on the available molecular information. SN - 1672-0229 UR - https://www.unboundmedicine.com/medline/citation/15629054/Molecular_advances_in_severe_acute_respiratory_syndrome_associated_coronavirus__SARS_CoV__ DB - PRIME DP - Unbound Medicine ER -