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Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer.
Cancer. 1992 May 01; 69(9):2244-51.C

Abstract

Data from a hospital-based case-control study between 1985-1990 were used to examine the effects of tobacco, alcohol, asbestos, and other occupational exposures on laryngeal cancer risk in 194 white men with primary cancer of the larynx and 184 age-matched control subjects. A dose-dependent effect for current cigarette smoking was observed, with higher relative risks (RR) for supraglottic cancer (RR, 21.6 to 68) than for cancer of the glottis (RR, 5.5 to 20.7). Elevated RR for ex-smokers (RR, 4.8) and pipe and cigar smokers (RR, 4.3) did not vary by subsite. The effects of alcohol also showed dose-dependent effects, with higher RR for cancer of the supraglottis than glottis for heavy drinkers (207 ml or more/daily; RR, 9.6 versus 2.5) and binge drinkers (RR, 28.4 versus 8.3). A slightly elevated but not significant association was seen for asbestos exposure and glottic cancer (RR, 1.3). The RR did not increase linearly with the number of years employed in asbestos-related occupations. No relationship was observed between asbestos and cancer of the supraglottis. When examining the data for a synergistic effect of cigarette smoking and asbestos exposure, no excess risk was found. A significantly elevated risk was found for men exposed to diesel fumes (RR, 5.2). Elevated but not significant RR were seen for men chronically exposed to rubber (RR, 6.4) and wood dust or employed as construction laborers, auto mechanics, and other jobs. A significant inverse trend with body mass was observed for cancer of the supraglottis.

Authors+Show Affiliations

Division of Epidemiology, American Health Foundation, New York, New York 10017.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1562970

Citation

Muscat, J E., and E L. Wynder. "Tobacco, Alcohol, Asbestos, and Occupational Risk Factors for Laryngeal Cancer." Cancer, vol. 69, no. 9, 1992, pp. 2244-51.
Muscat JE, Wynder EL. Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. Cancer. 1992;69(9):2244-51.
Muscat, J. E., & Wynder, E. L. (1992). Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. Cancer, 69(9), 2244-51.
Muscat JE, Wynder EL. Tobacco, Alcohol, Asbestos, and Occupational Risk Factors for Laryngeal Cancer. Cancer. 1992 May 1;69(9):2244-51. PubMed PMID: 1562970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. AU - Muscat,J E, AU - Wynder,E L, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 2244 EP - 51 JF - Cancer JO - Cancer VL - 69 IS - 9 N2 - Data from a hospital-based case-control study between 1985-1990 were used to examine the effects of tobacco, alcohol, asbestos, and other occupational exposures on laryngeal cancer risk in 194 white men with primary cancer of the larynx and 184 age-matched control subjects. A dose-dependent effect for current cigarette smoking was observed, with higher relative risks (RR) for supraglottic cancer (RR, 21.6 to 68) than for cancer of the glottis (RR, 5.5 to 20.7). Elevated RR for ex-smokers (RR, 4.8) and pipe and cigar smokers (RR, 4.3) did not vary by subsite. The effects of alcohol also showed dose-dependent effects, with higher RR for cancer of the supraglottis than glottis for heavy drinkers (207 ml or more/daily; RR, 9.6 versus 2.5) and binge drinkers (RR, 28.4 versus 8.3). A slightly elevated but not significant association was seen for asbestos exposure and glottic cancer (RR, 1.3). The RR did not increase linearly with the number of years employed in asbestos-related occupations. No relationship was observed between asbestos and cancer of the supraglottis. When examining the data for a synergistic effect of cigarette smoking and asbestos exposure, no excess risk was found. A significantly elevated risk was found for men exposed to diesel fumes (RR, 5.2). Elevated but not significant RR were seen for men chronically exposed to rubber (RR, 6.4) and wood dust or employed as construction laborers, auto mechanics, and other jobs. A significant inverse trend with body mass was observed for cancer of the supraglottis. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/1562970/Tobacco_alcohol_asbestos_and_occupational_risk_factors_for_laryngeal_cancer_ L2 - http://www.diseaseinfosearch.org/result/4098 DB - PRIME DP - Unbound Medicine ER -