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Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage.
Ann Intern Med 2005; 142(1):11-9AIM

Abstract

BACKGROUND

The association of light to moderate alcohol consumption with risk for ischemic stroke remains controversial, as do the roles of beverage type and drinking pattern.

OBJECTIVE

To assess the association of drinking patterns and beverage type with risk for ischemic stroke among men.

DESIGN

Prospective cohort study.

SETTING

United States.

PARTICIPANTS

38 156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986.

MEASUREMENTS

With a semi-quantitative food-frequency questionnaire, the authors individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0.1 to 9.9 g/d, or <1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (> or =30.0 g/d, or > or =3 drinks daily).

RESULTS

During a follow-up period of 14 years, 412 cases of incident ischemic stroke were documented. Compared with abstainers, light drinkers had a multivariate-adjusted relative risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate-adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a multivariate-adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P = 0.01 for trend). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week appeared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1.05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype.

LIMITATIONS

This study had limited power to examine specific drinking patterns and heavy drinking and could not assess risk for hemorrhagic stroke.

CONCLUSIONS

In this sample of male health professionals, light and moderate average alcohol use was generally not associated with an increased risk for ischemic stroke, although drinking pattern and beverage type modified this relation. Intake of more than 2 drinks per day may be associated with a higher risk for ischemic stroke.

Authors+Show Affiliations

Beth Israel Deaconess Medical Center, Harvard School of Public Health, Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, Massachusetts 02215, USA. kmukamal@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15630105

Citation

Mukamal, Kenneth J., et al. "Alcohol and Risk for Ischemic Stroke in Men: the Role of Drinking Patterns and Usual Beverage." Annals of Internal Medicine, vol. 142, no. 1, 2005, pp. 11-9.
Mukamal KJ, Ascherio A, Mittleman MA, et al. Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. Ann Intern Med. 2005;142(1):11-9.
Mukamal, K. J., Ascherio, A., Mittleman, M. A., Conigrave, K. M., Camargo, C. A., Kawachi, I., ... Rimm, E. B. (2005). Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. Annals of Internal Medicine, 142(1), pp. 11-9.
Mukamal KJ, et al. Alcohol and Risk for Ischemic Stroke in Men: the Role of Drinking Patterns and Usual Beverage. Ann Intern Med. 2005 Jan 4;142(1):11-9. PubMed PMID: 15630105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. AU - Mukamal,Kenneth J, AU - Ascherio,Alberto, AU - Mittleman,Murray A, AU - Conigrave,Katherine M, AU - Camargo,Carlos A,Jr AU - Kawachi,Ichiro, AU - Stampfer,Meir J, AU - Willett,Walter C, AU - Rimm,Eric B, PY - 2005/1/5/pubmed PY - 2005/2/3/medline PY - 2005/1/5/entrez SP - 11 EP - 9 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 142 IS - 1 N2 - BACKGROUND: The association of light to moderate alcohol consumption with risk for ischemic stroke remains controversial, as do the roles of beverage type and drinking pattern. OBJECTIVE: To assess the association of drinking patterns and beverage type with risk for ischemic stroke among men. DESIGN: Prospective cohort study. SETTING: United States. PARTICIPANTS: 38 156 male health professionals who were free of known cardiovascular disease or cancer at baseline in 1986. MEASUREMENTS: With a semi-quantitative food-frequency questionnaire, the authors individually ascertained consumption of regular and light beer, red and white wine, and liquor every 4 years. Alcohol consumption was categorized as light (0.1 to 9.9 g/d, or <1 drink daily), moderate (10.0 to 29.9 g/d, or 1 to 2 drinks daily), and heavier (> or =30.0 g/d, or > or =3 drinks daily). RESULTS: During a follow-up period of 14 years, 412 cases of incident ischemic stroke were documented. Compared with abstainers, light drinkers had a multivariate-adjusted relative risk of 0.99 (95% CI, 0.72 to 1.37), moderate drinkers had a multivariate-adjusted relative risk of 1.26 (CI, 0.90 to 1.76), and heavier drinkers had a multivariate-adjusted relative risk of 1.42 (CI, 0.97 to 2.09; P = 0.01 for trend). Consumption of 10.0 to 29.9 g of alcohol per day on 3 to 4 days per week appeared to be associated with the lowest risk (relative risk, 0.68 [CI, 0.44 to 1.05]). Red wine consumption was inversely associated with risk in a graded manner (P = 0.02 for trend), but other beverages were not. The apparently higher risk for ischemic stroke with heavier alcohol use appeared to be most pronounced for the embolic subtype. LIMITATIONS: This study had limited power to examine specific drinking patterns and heavy drinking and could not assess risk for hemorrhagic stroke. CONCLUSIONS: In this sample of male health professionals, light and moderate average alcohol use was generally not associated with an increased risk for ischemic stroke, although drinking pattern and beverage type modified this relation. Intake of more than 2 drinks per day may be associated with a higher risk for ischemic stroke. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/15630105/Alcohol_and_risk_for_ischemic_stroke_in_men:_the_role_of_drinking_patterns_and_usual_beverage_ L2 - https://www.annals.org/article.aspx?volume=142&amp;issue=1&amp;page=11 DB - PRIME DP - Unbound Medicine ER -