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Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease.
Am J Vet Res 2004; 65(12):1644-52AJ

Abstract

OBJECTIVE

To evaluate markers of hemostasis and their relationship to the degree of mitral regurgitation (MR) and platelet function in Cavalier King Charles Spaniels (CKCSs) with myxomatous mitral valve disease.

ANIMALS

76 clinically healthy CKCSs and 24 control dogs.

PROCEDURE

All dogs underwent echocardiographic examination; various hemostatic, hematologic, and biochemical variables were evaluated in blood. The CKCSs were allocated to 1 of 3 groups on the basis of MR severity. In 8 control dogs and 8 CKCSs, plasma von Willebrand factor (vWF) multimer analysis was performed.

RESULTS

Compared with control dogs, plasma fibrinogen concentration was higher in all CKCSs and related to left ventricular end diastolic diameter and left atrial-to-aortic root ratio among all CKCSs. The activated partial thromboplastin times and plasma D-dimer concentration were similar among the 4 groups. Plasma vWF concentration was lower in CKCSs with moderate to severe MR, compared with that of CKCSs with no MR and control dogs. There was a relationship between plasma vWF concentration and platelet function in CKCSs but not in control dogs. In 4 CKCSs with moderate to severe MR and low plasma vWF concentration, amounts of vWF high-molecular-weight multimers (HMWMs) were low.

CONCLUSIONS AND CLINICAL RELEVANCE

In CKCSs, MR appeared to be associated with a low plasma vWF concentration and likely a loss of vWF HMWMs (possibly through their destruction via shear stress to the blood). The importance of the changes in plasma fibrinogen concentration and the thromboembolic risk in dogs with MR remain to be investigated.

Authors+Show Affiliations

Departments of Animal and Veterinary Basic Sciences, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15631028

Citation

Tarnow, Inge, et al. "Assessment of Changes in Hemostatic Markers in Cavalier King Charles Spaniels With Myxomatous Mitral Valve Disease." American Journal of Veterinary Research, vol. 65, no. 12, 2004, pp. 1644-52.
Tarnow I, Kristensen AT, Olsen LH, et al. Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease. Am J Vet Res. 2004;65(12):1644-52.
Tarnow, I., Kristensen, A. T., Olsen, L. H., & Pedersen, H. D. (2004). Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease. American Journal of Veterinary Research, 65(12), pp. 1644-52.
Tarnow I, et al. Assessment of Changes in Hemostatic Markers in Cavalier King Charles Spaniels With Myxomatous Mitral Valve Disease. Am J Vet Res. 2004;65(12):1644-52. PubMed PMID: 15631028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of changes in hemostatic markers in Cavalier King Charles Spaniels with myxomatous mitral valve disease. AU - Tarnow,Inge, AU - Kristensen,Annemarie T, AU - Olsen,Lisbeth H, AU - Pedersen,Henrik D, PY - 2005/1/6/pubmed PY - 2005/3/23/medline PY - 2005/1/6/entrez SP - 1644 EP - 52 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 65 IS - 12 N2 - OBJECTIVE: To evaluate markers of hemostasis and their relationship to the degree of mitral regurgitation (MR) and platelet function in Cavalier King Charles Spaniels (CKCSs) with myxomatous mitral valve disease. ANIMALS: 76 clinically healthy CKCSs and 24 control dogs. PROCEDURE: All dogs underwent echocardiographic examination; various hemostatic, hematologic, and biochemical variables were evaluated in blood. The CKCSs were allocated to 1 of 3 groups on the basis of MR severity. In 8 control dogs and 8 CKCSs, plasma von Willebrand factor (vWF) multimer analysis was performed. RESULTS: Compared with control dogs, plasma fibrinogen concentration was higher in all CKCSs and related to left ventricular end diastolic diameter and left atrial-to-aortic root ratio among all CKCSs. The activated partial thromboplastin times and plasma D-dimer concentration were similar among the 4 groups. Plasma vWF concentration was lower in CKCSs with moderate to severe MR, compared with that of CKCSs with no MR and control dogs. There was a relationship between plasma vWF concentration and platelet function in CKCSs but not in control dogs. In 4 CKCSs with moderate to severe MR and low plasma vWF concentration, amounts of vWF high-molecular-weight multimers (HMWMs) were low. CONCLUSIONS AND CLINICAL RELEVANCE: In CKCSs, MR appeared to be associated with a low plasma vWF concentration and likely a loss of vWF HMWMs (possibly through their destruction via shear stress to the blood). The importance of the changes in plasma fibrinogen concentration and the thromboembolic risk in dogs with MR remain to be investigated. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/15631028/Assessment_of_changes_in_hemostatic_markers_in_Cavalier_King_Charles_Spaniels_with_myxomatous_mitral_valve_disease_ L2 - https://medlineplus.gov/heartvalvediseases.html DB - PRIME DP - Unbound Medicine ER -