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Automated office and home phone-transmitted blood pressure recordings in uncontrolled hypertension treated with valsartan and hydrochlorothiazide.
Blood Press Suppl 2004; 2:18-24BP

Abstract

The study objective was to evaluate, by means of automated office and phone-transmitted home blood pressure (OBP and HBP) recordings, the effects of a fixed combination of valsartan 160 mg and hydrochlorothiazide (HCTZ) 25 mg in hypertensive patients previously uncontrolled with the combination of an angiotensin receptor antagonist and HCTZ. From 241 selected patients, 171 (71%) had uncontrolled hypertension OBP and HBP [mean baseline OBP and HBP systolic and diastolic (SBP/DBP): 157/91 and 152/87 mmHg]. In this open-design study, patients were directly switched from other angiotensin receptor blocker combination products to valsartan/HCTZ for 6 weeks. The same validated automated device was used for OBP and HBP recordings. At baseline, mean HBP was 152 +/- 15/87 +/- 10 mmHg and mean OBP was 157 +/- 12/91 +/- 9 mmHg. After 6 weeks of treatment with valsartan 160 mg and HCTZ 25 mg, a significant decrease in BP was observed both at home (146 +/- 17/83 +/- 12 mmHg) and at the office (151 +/- 18/87 +/- 11 mmHg), with a difference from baseline of -4 mmHg, p < 0.001 for DBP and of -6 mmHg for SBP, p < 0.001. The percentage of patients with office and home control was 24% and 23% respectively, with a kappa index at 0.459. Elevated OBP only (office hypertension) was observed in 3.6% and elevated HBP only (masked hypertension) in 10% of patients. In conclusion, treatment with valsartan and HCTZ 25 mg in patients with confirmed uncontrolled hypertension induced a clinically relevant decrease in BP with approximately 23% of additional patients strictly controlled with a single tablet. The use of an automated oscillometric device at the office and at home allowed the detection of controlled subjects with good agreement.

Authors+Show Affiliations

Service d'Endocrinologie et Métabolisme, Hôpital de La Pitié, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15631279

Citation

Girerd, Xavier, et al. "Automated Office and Home Phone-transmitted Blood Pressure Recordings in Uncontrolled Hypertension Treated With Valsartan and Hydrochlorothiazide." Blood Pressure. Supplement, vol. 2, 2004, pp. 18-24.
Girerd X, Denolle T, Yau C, et al. Automated office and home phone-transmitted blood pressure recordings in uncontrolled hypertension treated with valsartan and hydrochlorothiazide. Blood Press Suppl. 2004;2:18-24.
Girerd, X., Denolle, T., Yau, C., Fiquet, B., Brunel, P., Moulin, B., & Herpin, D. (2004). Automated office and home phone-transmitted blood pressure recordings in uncontrolled hypertension treated with valsartan and hydrochlorothiazide. Blood Pressure. Supplement, 2, pp. 18-24.
Girerd X, et al. Automated Office and Home Phone-transmitted Blood Pressure Recordings in Uncontrolled Hypertension Treated With Valsartan and Hydrochlorothiazide. Blood Press Suppl. 2004;2:18-24. PubMed PMID: 15631279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Automated office and home phone-transmitted blood pressure recordings in uncontrolled hypertension treated with valsartan and hydrochlorothiazide. AU - Girerd,Xavier, AU - Denolle,Thierry, AU - Yau,Caroline, AU - Fiquet,Béatrice, AU - Brunel,Patrick, AU - Moulin,Bruno, AU - Herpin,Daniel, PY - 2005/1/6/pubmed PY - 2005/5/6/medline PY - 2005/1/6/entrez SP - 18 EP - 24 JF - Blood pressure. Supplement JO - Blood Press Suppl VL - 2 N2 - The study objective was to evaluate, by means of automated office and phone-transmitted home blood pressure (OBP and HBP) recordings, the effects of a fixed combination of valsartan 160 mg and hydrochlorothiazide (HCTZ) 25 mg in hypertensive patients previously uncontrolled with the combination of an angiotensin receptor antagonist and HCTZ. From 241 selected patients, 171 (71%) had uncontrolled hypertension OBP and HBP [mean baseline OBP and HBP systolic and diastolic (SBP/DBP): 157/91 and 152/87 mmHg]. In this open-design study, patients were directly switched from other angiotensin receptor blocker combination products to valsartan/HCTZ for 6 weeks. The same validated automated device was used for OBP and HBP recordings. At baseline, mean HBP was 152 +/- 15/87 +/- 10 mmHg and mean OBP was 157 +/- 12/91 +/- 9 mmHg. After 6 weeks of treatment with valsartan 160 mg and HCTZ 25 mg, a significant decrease in BP was observed both at home (146 +/- 17/83 +/- 12 mmHg) and at the office (151 +/- 18/87 +/- 11 mmHg), with a difference from baseline of -4 mmHg, p < 0.001 for DBP and of -6 mmHg for SBP, p < 0.001. The percentage of patients with office and home control was 24% and 23% respectively, with a kappa index at 0.459. Elevated OBP only (office hypertension) was observed in 3.6% and elevated HBP only (masked hypertension) in 10% of patients. In conclusion, treatment with valsartan and HCTZ 25 mg in patients with confirmed uncontrolled hypertension induced a clinically relevant decrease in BP with approximately 23% of additional patients strictly controlled with a single tablet. The use of an automated oscillometric device at the office and at home allowed the detection of controlled subjects with good agreement. SN - 0803-8023 UR - https://www.unboundmedicine.com/medline/citation/15631279/Automated_office_and_home_phone_transmitted_blood_pressure_recordings_in_uncontrolled_hypertension_treated_with_valsartan_and_hydrochlorothiazide_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=15631279.ui DB - PRIME DP - Unbound Medicine ER -