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Gastric acid and salivary bicarbonate. Is there a relationship in duodenal ulcer patients?
Rocz Akad Med Bialymst. 2004; 49:75-9.RA

Abstract

PURPOSE

Since saliva protects the oesophageal and oral mucosa against hydrogen ions, the aim of the study was to establish the relationship between the secretion of gastric acid and salivary bicarbonate.

MATERIAL AND METHODS

The study involved 43 Helicobacter pylori positive duodenal ulcer patients receiving: 1. omeprazole alone (O), 2. omeprazole and amoxicillin (OA) or 3. omeprazole, amoxicillin and tinidazole (OAT). In each study group the examination was performed twice, before and at the end of a two-week treatment, both under basal conditions and during a gastric secretory test with pentagastrin. Concentrations of gastric hydrogen ions and salivary bicarbonate were evaluated by the titration method.

RESULTS

In all therapeutic groups analysed separately, the secretion of gastric acid as well as salivary bicarbonate decreased at the end of the treatment, however only in OA and OAT groups the differences in bicarbonate reached statistical significance. As the changes in the concentration and output of both salivary bicarbonate and gastric acid had the same direction, the three therapeutic groups (O, OA, OAT) were subjected to combined analysis. It showed that under basal conditions and during stimulation with a gastric catheter or catheter and pentagastrin, bicarbonate concentration and output were higher before than at the end of the treatment. However, no direct correlation between gastric acid secretion and salivary bicarbonate was found in groups subjected to either separate or combined analysis.

CONCLUSIONS

The results of our study provide evidence for the partial involvement of hydrogen ions of gastric origin in the regulation of salivary bicarbonate secretion in duodenal ulcer patients.

Authors+Show Affiliations

Namiot Z
Department of Medicine and Gastroenterology, J. Sniadecki District Hospital, Białystok, Poland. namiotz@poczta.onet.pl
Stasiewicz J
No affiliation info available
Markowski AR
No affiliation info available
Namiot DB
No affiliation info available
Jaroszewicz W
No affiliation info available
Kemona A
No affiliation info available
Górski J
No affiliation info available

MeSH

AdultAmoxicillinAnti-Bacterial AgentsAnti-Ulcer AgentsBicarbonatesDrug Therapy, CombinationDuodenal UlcerFemaleGastric AcidHumansHydrogen-Ion ConcentrationMaleMiddle AgedOmeprazoleSalivaTinidazoleTreatment Outcome

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15631318

Citation

Namiot, Z, et al. "Gastric Acid and Salivary Bicarbonate. Is There a Relationship in Duodenal Ulcer Patients?" Roczniki Akademii Medycznej W Bialymstoku (1995), vol. 49, 2004, pp. 75-9.
Namiot Z, Stasiewicz J, Markowski AR, et al. Gastric acid and salivary bicarbonate. Is there a relationship in duodenal ulcer patients? Rocz Akad Med Bialymst. 2004;49:75-9.
Namiot, Z., Stasiewicz, J., Markowski, A. R., Namiot, D. B., Jaroszewicz, W., Kemona, A., & Górski, J. (2004). Gastric acid and salivary bicarbonate. Is there a relationship in duodenal ulcer patients? Roczniki Akademii Medycznej W Bialymstoku (1995), 49, 75-9.
Namiot Z, et al. Gastric Acid and Salivary Bicarbonate. Is There a Relationship in Duodenal Ulcer Patients. Rocz Akad Med Bialymst. 2004;49:75-9. PubMed PMID: 15631318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric acid and salivary bicarbonate. Is there a relationship in duodenal ulcer patients? AU - Namiot,Z, AU - Stasiewicz,J, AU - Markowski,A R, AU - Namiot,D B, AU - Jaroszewicz,W, AU - Kemona,A, AU - Górski,J, PY - 2005/1/6/pubmed PY - 2005/3/30/medline PY - 2005/1/6/entrez SP - 75 EP - 9 JF - Roczniki Akademii Medycznej w Bialymstoku (1995) JO - Rocz Akad Med Bialymst VL - 49 N2 - PURPOSE: Since saliva protects the oesophageal and oral mucosa against hydrogen ions, the aim of the study was to establish the relationship between the secretion of gastric acid and salivary bicarbonate. MATERIAL AND METHODS: The study involved 43 Helicobacter pylori positive duodenal ulcer patients receiving: 1. omeprazole alone (O), 2. omeprazole and amoxicillin (OA) or 3. omeprazole, amoxicillin and tinidazole (OAT). In each study group the examination was performed twice, before and at the end of a two-week treatment, both under basal conditions and during a gastric secretory test with pentagastrin. Concentrations of gastric hydrogen ions and salivary bicarbonate were evaluated by the titration method. RESULTS: In all therapeutic groups analysed separately, the secretion of gastric acid as well as salivary bicarbonate decreased at the end of the treatment, however only in OA and OAT groups the differences in bicarbonate reached statistical significance. As the changes in the concentration and output of both salivary bicarbonate and gastric acid had the same direction, the three therapeutic groups (O, OA, OAT) were subjected to combined analysis. It showed that under basal conditions and during stimulation with a gastric catheter or catheter and pentagastrin, bicarbonate concentration and output were higher before than at the end of the treatment. However, no direct correlation between gastric acid secretion and salivary bicarbonate was found in groups subjected to either separate or combined analysis. CONCLUSIONS: The results of our study provide evidence for the partial involvement of hydrogen ions of gastric origin in the regulation of salivary bicarbonate secretion in duodenal ulcer patients. UR - https://www.unboundmedicine.com/medline/citation/15631318/Gastric_acid_and_salivary_bicarbonate__Is_there_a_relationship_in_duodenal_ulcer_patients DB - PRIME DP - Unbound Medicine ER -