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[Serological investigation on close contacts to patients with severe acute respiratory syndrome in an SARS outbreak].
Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Oct; 25(10):867-9.ZL

Abstract

OBJECTIVE

To study the evidence of severe acute respiratory syndrome (SARS) infection among close contacts to SARS patients and the level of sera IgG antibody in SARS cases.

METHODS

Specific IgG antibody against SARS-CoV in serum samples from contacts to patients, five months before an SARS outbreak in Beijing. Neutralized test, ELISA and immunity adherence test were studied. Samples were collected after clinical onset of patients or close contacts to patients, for 22 - 24 weeks. 19 close contacts and 13 cases were included in the study.

RESULTS

In close contacts, all tests were negative on three methods. All SARS cases were positive except one by immunity adherence test. The neutralized antibody levels were from 1:16 to 1:203, with medium level of 1:43.

CONCLUSION

According to our survey, there was no latent infection among close contacts. IgG antibody in sera continued to be at higher levels among SARS cases 22 - 24 weeks after onset.

Authors+Show Affiliations

Xie SY
Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zeng G
No affiliation info available
Chen JT
No affiliation info available
Liu YX
No affiliation info available
Li SF
No affiliation info available
Yin WD
No affiliation info available

MeSH

Antibodies, ViralChinaDisease OutbreaksFemaleHumansImmunoglobulin GMaleSevere acute respiratory syndrome-related coronavirusSeroepidemiologic StudiesSevere Acute Respiratory Syndrome

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15631743

Citation

Xie, Shu-yun, et al. "[Serological Investigation On Close Contacts to Patients With Severe Acute Respiratory Syndrome in an SARS Outbreak]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 25, no. 10, 2004, pp. 867-9.
Xie SY, Zeng G, Chen JT, et al. [Serological investigation on close contacts to patients with severe acute respiratory syndrome in an SARS outbreak]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25(10):867-9.
Xie, S. Y., Zeng, G., Chen, J. T., Liu, Y. X., Li, S. F., & Yin, W. D. (2004). [Serological investigation on close contacts to patients with severe acute respiratory syndrome in an SARS outbreak]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 25(10), 867-9.
Xie SY, et al. [Serological Investigation On Close Contacts to Patients With Severe Acute Respiratory Syndrome in an SARS Outbreak]. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25(10):867-9. PubMed PMID: 15631743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serological investigation on close contacts to patients with severe acute respiratory syndrome in an SARS outbreak]. AU - Xie,Shu-yun, AU - Zeng,Guang, AU - Chen,Jiang-ting, AU - Liu,Yu-xuan, AU - Li,Shu-fen, AU - Yin,Wei-dong, PY - 2005/1/6/pubmed PY - 2005/10/28/medline PY - 2005/1/6/entrez SP - 867 EP - 9 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 25 IS - 10 N2 - OBJECTIVE: To study the evidence of severe acute respiratory syndrome (SARS) infection among close contacts to SARS patients and the level of sera IgG antibody in SARS cases. METHODS: Specific IgG antibody against SARS-CoV in serum samples from contacts to patients, five months before an SARS outbreak in Beijing. Neutralized test, ELISA and immunity adherence test were studied. Samples were collected after clinical onset of patients or close contacts to patients, for 22 - 24 weeks. 19 close contacts and 13 cases were included in the study. RESULTS: In close contacts, all tests were negative on three methods. All SARS cases were positive except one by immunity adherence test. The neutralized antibody levels were from 1:16 to 1:203, with medium level of 1:43. CONCLUSION: According to our survey, there was no latent infection among close contacts. IgG antibody in sera continued to be at higher levels among SARS cases 22 - 24 weeks after onset. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/15631743/[Serological_investigation_on_close_contacts_to_patients_with_severe_acute_respiratory_syndrome_in_an_SARS_outbreak]_ DB - PRIME DP - Unbound Medicine ER -