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Plasma carotenoids, retinol, and tocopherols and risk of breast cancer.
Am J Epidemiol 2005; 161(2):153-60AJ

Abstract

The roles of carotenoids, retinol, and tocopherols in breast cancer etiology have been inconclusive. The authors prospectively assessed the relations between plasma alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, alpha-tocopherol, and gamma-tocopherol and breast cancer risk by conducting a nested case-control study using plasma collected from women enrolled in the Nurses' Health Study. A total of 969 cases of breast cancer diagnosed after blood draw and prior to June 1, 1998, were individually matched to controls. The multivariate risk of breast cancer was 25-35% less for women with the highest quintile compared with that for women with the lowest quintile of alpha-carotene (odds ratio (OR) = 0.64, 95% confidence interval (CI): 0.47, 0.88; p(trend) = 0.01), beta-carotene (OR = 0.73, 95% CI: 0.53, 1.02; p(trend) = 0.01), lutein/zeaxanthin (OR = 0.74, 95% CI: 0.55, 1.01; p(trend) = 0.04), and total carotenoids (OR = 0.76, 95% CI: 0.55, 1.05; p(trend) = 0.05). The inverse association observed with alpha-carotene and breast cancer was greater for invasive cancers with nodal metastasis. The authors conclude that some carotenoids are inversely associated with breast cancer. Although the association was strongest for alpha-carotene, the high degree of collinearity among plasma carotenoids limits our ability to conclude that this association is specific to any individual carotenoid.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Boston, MA 02115, USA. rulla.tamimi@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15632265

Citation

Tamimi, Rulla M., et al. "Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer." American Journal of Epidemiology, vol. 161, no. 2, 2005, pp. 153-60.
Tamimi RM, Hankinson SE, Campos H, et al. Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. Am J Epidemiol. 2005;161(2):153-60.
Tamimi, R. M., Hankinson, S. E., Campos, H., Spiegelman, D., Zhang, S., Colditz, G. A., ... Hunter, D. J. (2005). Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. American Journal of Epidemiology, 161(2), pp. 153-60.
Tamimi RM, et al. Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer. Am J Epidemiol. 2005 Jan 15;161(2):153-60. PubMed PMID: 15632265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. AU - Tamimi,Rulla M, AU - Hankinson,Susan E, AU - Campos,Hannia, AU - Spiegelman,Donna, AU - Zhang,Shumin, AU - Colditz,Graham A, AU - Willett,Walter C, AU - Hunter,David J, PY - 2005/1/6/pubmed PY - 2005/2/26/medline PY - 2005/1/6/entrez SP - 153 EP - 60 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 2 N2 - The roles of carotenoids, retinol, and tocopherols in breast cancer etiology have been inconclusive. The authors prospectively assessed the relations between plasma alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, alpha-tocopherol, and gamma-tocopherol and breast cancer risk by conducting a nested case-control study using plasma collected from women enrolled in the Nurses' Health Study. A total of 969 cases of breast cancer diagnosed after blood draw and prior to June 1, 1998, were individually matched to controls. The multivariate risk of breast cancer was 25-35% less for women with the highest quintile compared with that for women with the lowest quintile of alpha-carotene (odds ratio (OR) = 0.64, 95% confidence interval (CI): 0.47, 0.88; p(trend) = 0.01), beta-carotene (OR = 0.73, 95% CI: 0.53, 1.02; p(trend) = 0.01), lutein/zeaxanthin (OR = 0.74, 95% CI: 0.55, 1.01; p(trend) = 0.04), and total carotenoids (OR = 0.76, 95% CI: 0.55, 1.05; p(trend) = 0.05). The inverse association observed with alpha-carotene and breast cancer was greater for invasive cancers with nodal metastasis. The authors conclude that some carotenoids are inversely associated with breast cancer. Although the association was strongest for alpha-carotene, the high degree of collinearity among plasma carotenoids limits our ability to conclude that this association is specific to any individual carotenoid. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15632265/Plasma_carotenoids_retinol_and_tocopherols_and_risk_of_breast_cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi030 DB - PRIME DP - Unbound Medicine ER -