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Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis.
J Natl Cancer Inst. 2005 Jan 05; 97(1):51-9.JNCI

Abstract

BACKGROUND

The PROGINS allele of the progesterone receptor (PGR) gene has been associated with an increased risk of ovarian cancer and a decreased risk of breast cancer. We set out to refine the association between common variation at the PGR gene locus and these two diseases.

METHODS

We characterized the haplotype structure of the PGR gene by genotyping 54 single-nucleotide polymorphisms (SNPs) in 349 women. We then selected a subset of 17 haplotype-tagging SNPs that captured variation across the locus and typed them in 267 ovarian cancer case patients and 397 control subjects from two case-control studies and in 1715 breast cancer case patients and 2505 control subjects from a cohort study.

RESULTS

The PGR locus was characterized by four blocks of strong linkage disequilibrium. Two SNPs in block 4 were associated with an increased risk of ovarian cancer among homozygous carriers as compared with noncarriers: rs1042838 (PROGINS allele; odds ratio [OR] = 3.23, 95% confidence interval [CI] = 1.19 to 8.75, P = .022) and rs608995 (minor allele; OR = 3.10, 95% CI = 1.63 to 5.89, P<.001). The PROGINS allele was observed on a subset of chromosomes carrying the minor allele at rs608995, and its association with ovarian cancer was fully explained by its association with rs608995. In addition, rs608995 fell on two common haplotypes (4-D and 4-E), whose association with ovarian cancer was the same as that of rs608995. These same two haplotypes were associated with a non-statistically significantly reduced risk of breast cancer.

CONCLUSIONS

Variation in PGR was associated with ovarian cancer risk, although the strongest result was not with the PROGINS allele. Instead, any causal allele(s) are likely in or downstream of block 4 and carried on haplotypes 4-D and 4-E. There was some evidence that the same variation was associated with a reduced risk of breast cancer, but the association was not statistically significant.

Authors+Show Affiliations

Department of Preventive Medicine, Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA. cpearce@usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15632380

Citation

Pearce, Celeste Leigh, et al. "Clarifying the PROGINS Allele Association in Ovarian and Breast Cancer Risk: a Haplotype-based Analysis." Journal of the National Cancer Institute, vol. 97, no. 1, 2005, pp. 51-9.
Pearce CL, Hirschhorn JN, Wu AH, et al. Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis. J Natl Cancer Inst. 2005;97(1):51-9.
Pearce, C. L., Hirschhorn, J. N., Wu, A. H., Burtt, N. P., Stram, D. O., Young, S., Kolonel, L. N., Henderson, B. E., Altshuler, D., & Pike, M. C. (2005). Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis. Journal of the National Cancer Institute, 97(1), 51-9.
Pearce CL, et al. Clarifying the PROGINS Allele Association in Ovarian and Breast Cancer Risk: a Haplotype-based Analysis. J Natl Cancer Inst. 2005 Jan 5;97(1):51-9. PubMed PMID: 15632380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis. AU - Pearce,Celeste Leigh, AU - Hirschhorn,Joel N, AU - Wu,Anna H, AU - Burtt,Noël P, AU - Stram,Daniel O, AU - Young,Stanton, AU - Kolonel,Laurence N, AU - Henderson,Brian E, AU - Altshuler,David, AU - Pike,Malcolm C, PY - 2005/1/6/pubmed PY - 2005/1/22/medline PY - 2005/1/6/entrez SP - 51 EP - 9 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 97 IS - 1 N2 - BACKGROUND: The PROGINS allele of the progesterone receptor (PGR) gene has been associated with an increased risk of ovarian cancer and a decreased risk of breast cancer. We set out to refine the association between common variation at the PGR gene locus and these two diseases. METHODS: We characterized the haplotype structure of the PGR gene by genotyping 54 single-nucleotide polymorphisms (SNPs) in 349 women. We then selected a subset of 17 haplotype-tagging SNPs that captured variation across the locus and typed them in 267 ovarian cancer case patients and 397 control subjects from two case-control studies and in 1715 breast cancer case patients and 2505 control subjects from a cohort study. RESULTS: The PGR locus was characterized by four blocks of strong linkage disequilibrium. Two SNPs in block 4 were associated with an increased risk of ovarian cancer among homozygous carriers as compared with noncarriers: rs1042838 (PROGINS allele; odds ratio [OR] = 3.23, 95% confidence interval [CI] = 1.19 to 8.75, P = .022) and rs608995 (minor allele; OR = 3.10, 95% CI = 1.63 to 5.89, P<.001). The PROGINS allele was observed on a subset of chromosomes carrying the minor allele at rs608995, and its association with ovarian cancer was fully explained by its association with rs608995. In addition, rs608995 fell on two common haplotypes (4-D and 4-E), whose association with ovarian cancer was the same as that of rs608995. These same two haplotypes were associated with a non-statistically significantly reduced risk of breast cancer. CONCLUSIONS: Variation in PGR was associated with ovarian cancer risk, although the strongest result was not with the PROGINS allele. Instead, any causal allele(s) are likely in or downstream of block 4 and carried on haplotypes 4-D and 4-E. There was some evidence that the same variation was associated with a reduced risk of breast cancer, but the association was not statistically significant. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/15632380/Clarifying_the_PROGINS_allele_association_in_ovarian_and_breast_cancer_risk:_a_haplotype_based_analysis_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/dji007 DB - PRIME DP - Unbound Medicine ER -