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Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat.
Proc West Pharmacol Soc. 2004; 47:92-4.PW

Abstract

B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. More recently it has been claimed that B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. In Latin America, B vitamins are commonly used to treat neuropathic pain; however, there is no data to support this indication. In the present work we assessed the possible analgesic activity of vitamin B12 alone and combined with diclofenac in a neuropathic pain model in the rat. Neuropathic pain was induced by ligation of the left L5 and L6 spinal nerves of female Wistar rats. Tactile allodynia was determined by measuring paw withdrawal in response to probing with a series of calibrated von Frey filaments. Vitamin B12 (0.75-6 mg/kg), but not diclofenac (1-10 mg/kg), reduced in a dose-dependent manner tactile allodynia induced by spinal nerve ligation. Diclofenac (3.2 mg/kg) was not able to further increase vitamin B12-induced antiallodynia. Results indicate that vitamin B12, but not diclofenac, produces antiallodynic effects in the rat and suggest that this vitamin could be a potential treatment for neuropathic pain in humans.

Authors+Show Affiliations

Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, DF, Mexico vgranados@prodigy.net.mxNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15633622

Citation

Granados-Soto, Vinicio, et al. "Effect of Diclofenac On the Antiallodynic Activity of Vitamin B12 in a Neuropathic Pain Model in the Rat." Proceedings of the Western Pharmacology Society, vol. 47, 2004, pp. 92-4.
Granados-Soto V, Sánchez-Ramirez G, la Torre MR, et al. Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat. Proc West Pharmacol Soc. 2004;47:92-4.
Granados-Soto, V., Sánchez-Ramirez, G., la Torre, M. R., Caram-Salas, N. L., Medina-Santillán, R., & Reyes-García, G. (2004). Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat. Proceedings of the Western Pharmacology Society, 47, 92-4.
Granados-Soto V, et al. Effect of Diclofenac On the Antiallodynic Activity of Vitamin B12 in a Neuropathic Pain Model in the Rat. Proc West Pharmacol Soc. 2004;47:92-4. PubMed PMID: 15633622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat. AU - Granados-Soto,Vinicio, AU - Sánchez-Ramirez,Gabriela, AU - la Torre,Magally Rosas-de, AU - Caram-Salas,Nadia L, AU - Medina-Santillán,Roberto, AU - Reyes-García,Gerardo, PY - 2005/1/7/pubmed PY - 2005/1/27/medline PY - 2005/1/7/entrez SP - 92 EP - 4 JF - Proceedings of the Western Pharmacology Society JO - Proc West Pharmacol Soc VL - 47 N2 - B vitamins have been used as analgesic drugs to treat pain disorders associated with their deficiency. More recently it has been claimed that B vitamins are useful to relieve different pain states as carpal tunnel, migraine and premenstrual tension. In Latin America, B vitamins are commonly used to treat neuropathic pain; however, there is no data to support this indication. In the present work we assessed the possible analgesic activity of vitamin B12 alone and combined with diclofenac in a neuropathic pain model in the rat. Neuropathic pain was induced by ligation of the left L5 and L6 spinal nerves of female Wistar rats. Tactile allodynia was determined by measuring paw withdrawal in response to probing with a series of calibrated von Frey filaments. Vitamin B12 (0.75-6 mg/kg), but not diclofenac (1-10 mg/kg), reduced in a dose-dependent manner tactile allodynia induced by spinal nerve ligation. Diclofenac (3.2 mg/kg) was not able to further increase vitamin B12-induced antiallodynia. Results indicate that vitamin B12, but not diclofenac, produces antiallodynic effects in the rat and suggest that this vitamin could be a potential treatment for neuropathic pain in humans. SN - 0083-8969 UR - https://www.unboundmedicine.com/medline/citation/15633622/Effect_of_diclofenac_on_the_antiallodynic_activity_of_vitamin_B12_in_a_neuropathic_pain_model_in_the_rat_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -