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Ability of new APTIMA CT and APTIMA GC assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae in male urine and urethral swabs.
J Clin Microbiol. 2005 Jan; 43(1):127-31.JC

Abstract

A clinical evaluation was conducted in six North American centers to determine the ability of APTIMA CT (ACT) and APTIMA GC (AGC) nucleic acid amplification assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections in 1,322 men by testing their urethral swabs and first-catch urine (FCU). The results obtained with ACT and AGC assays were compared to an infected patient status determined by testing the specimens with the APTIMA Combo 2 and the BD ProbeTec energy transfer multiplex assays. Symptoms did not influence the values. Positive and negative agreements of the ACT and AGC assays for individual specimens were high, with each comparator assay ranging between 94.3 and 100% for positives and 93.9 and 99.4% for negatives. The ACT and AGC assays performed on noninvasive specimens such as FCU effectively identified C. trachomatis or N. gonorrhoeae infections in symptomatic and asymptomatic men and should be suitable for screening male populations.

Authors+Show Affiliations

St. Joseph's Healthcare, Hamilton, Ontario, Canada L8N 4A6. chernesk@mcmaster.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

15634960

Citation

Chernesky, M A., et al. "Ability of New APTIMA CT and APTIMA GC Assays to Detect Chlamydia Trachomatis and Neisseria Gonorrhoeae in Male Urine and Urethral Swabs." Journal of Clinical Microbiology, vol. 43, no. 1, 2005, pp. 127-31.
Chernesky MA, Martin DH, Hook EW, et al. Ability of new APTIMA CT and APTIMA GC assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae in male urine and urethral swabs. J Clin Microbiol. 2005;43(1):127-31.
Chernesky, M. A., Martin, D. H., Hook, E. W., Willis, D., Jordan, J., Wang, S., Lane, J. R., Fuller, D., & Schachter, J. (2005). Ability of new APTIMA CT and APTIMA GC assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae in male urine and urethral swabs. Journal of Clinical Microbiology, 43(1), 127-31.
Chernesky MA, et al. Ability of New APTIMA CT and APTIMA GC Assays to Detect Chlamydia Trachomatis and Neisseria Gonorrhoeae in Male Urine and Urethral Swabs. J Clin Microbiol. 2005;43(1):127-31. PubMed PMID: 15634960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ability of new APTIMA CT and APTIMA GC assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae in male urine and urethral swabs. AU - Chernesky,M A, AU - Martin,D H, AU - Hook,E W, AU - Willis,D, AU - Jordan,J, AU - Wang,S, AU - Lane,J R, AU - Fuller,D, AU - Schachter,J, PY - 2005/1/7/pubmed PY - 2005/3/2/medline PY - 2005/1/7/entrez SP - 127 EP - 31 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 43 IS - 1 N2 - A clinical evaluation was conducted in six North American centers to determine the ability of APTIMA CT (ACT) and APTIMA GC (AGC) nucleic acid amplification assays to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections in 1,322 men by testing their urethral swabs and first-catch urine (FCU). The results obtained with ACT and AGC assays were compared to an infected patient status determined by testing the specimens with the APTIMA Combo 2 and the BD ProbeTec energy transfer multiplex assays. Symptoms did not influence the values. Positive and negative agreements of the ACT and AGC assays for individual specimens were high, with each comparator assay ranging between 94.3 and 100% for positives and 93.9 and 99.4% for negatives. The ACT and AGC assays performed on noninvasive specimens such as FCU effectively identified C. trachomatis or N. gonorrhoeae infections in symptomatic and asymptomatic men and should be suitable for screening male populations. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/15634960/Ability_of_new_APTIMA_CT_and_APTIMA_GC_assays_to_detect_Chlamydia_trachomatis_and_Neisseria_gonorrhoeae_in_male_urine_and_urethral_swabs_ L2 - http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=15634960 DB - PRIME DP - Unbound Medicine ER -