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Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice.
J Am Diet Assoc. 2005 Jan; 105(1):46-52.JA

Abstract

OBJECTIVE

To determine the effectiveness of prescribing 2 g plant sterols/stanols per day as an addition to standard practice in a dietary outpatient clinic.

DESIGN

A randomized parallel design of comparative 12-week interventions.

SUBJECTS/SETTING

Patients referred by a general practitioner to a dietary outpatient clinic for the management of hyperlipidemia were eligible. Twenty-five patients (15 women and 10 men) completed the study.

INTERVENTION

Counseling regarding diet for hyperlipidemia was based on the National Cholesterol Education Program guidelines. The intervention group was instructed to incorporate approximately 25 g/day of margarine, containing plant sterols/stanols, which delivered approximately 2 g plant sterols/stanols.

MAIN OUTCOME MEASURE

Changes in diet, body weight, and serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were measured.

STATISTICAL ANALYSIS PERFORMED

Changes in dietary and biochemical outcomes were assessed using Student's t test. For nonnormally distributed data, Wilcoxon signed rank test was used, and Mann-Whitney U tests were conducted to determine the proportion of subjects reaching defined goals. The number needed to treat index was used to report effectiveness of the intervention.

RESULTS

Five of 14 subjects in the intervention group compared with 0 of 11 in the control group achieved a reduction in serum cholesterol of >/=15% (P <.05). Using the number needed to treat index, for each 2.8 patients counseled with routine prescription of plant sterols/stanols, one additional patient would obtain a reduction in cholesterol by >/=15% compared with conventional management. This was achieved without any detrimental effects on the dietary fatty acid profile.

CONCLUSIONS

Routine prescription of margarine containing plant sterol/stanol is an effective strategy in the management of hypercholesterolemic patients in the clinical setting.

Authors+Show Affiliations

Smart Foods Centre, University of Wollongong, NSW 2522, Australia. csp03@wow.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15635344

Citation

Patch, Craig S., et al. "Plant Sterol/stanol Prescription Is an Effective Treatment Strategy for Managing Hypercholesterolemia in Outpatient Clinical Practice." Journal of the American Dietetic Association, vol. 105, no. 1, 2005, pp. 46-52.
Patch CS, Tapsell LC, Williams PG. Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice. J Am Diet Assoc. 2005;105(1):46-52.
Patch, C. S., Tapsell, L. C., & Williams, P. G. (2005). Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice. Journal of the American Dietetic Association, 105(1), 46-52.
Patch CS, Tapsell LC, Williams PG. Plant Sterol/stanol Prescription Is an Effective Treatment Strategy for Managing Hypercholesterolemia in Outpatient Clinical Practice. J Am Diet Assoc. 2005;105(1):46-52. PubMed PMID: 15635344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant sterol/stanol prescription is an effective treatment strategy for managing hypercholesterolemia in outpatient clinical practice. AU - Patch,Craig S, AU - Tapsell,Linda C, AU - Williams,Peter G, PY - 2005/1/7/pubmed PY - 2005/2/18/medline PY - 2005/1/7/entrez SP - 46 EP - 52 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 105 IS - 1 N2 - OBJECTIVE: To determine the effectiveness of prescribing 2 g plant sterols/stanols per day as an addition to standard practice in a dietary outpatient clinic. DESIGN: A randomized parallel design of comparative 12-week interventions. SUBJECTS/SETTING: Patients referred by a general practitioner to a dietary outpatient clinic for the management of hyperlipidemia were eligible. Twenty-five patients (15 women and 10 men) completed the study. INTERVENTION: Counseling regarding diet for hyperlipidemia was based on the National Cholesterol Education Program guidelines. The intervention group was instructed to incorporate approximately 25 g/day of margarine, containing plant sterols/stanols, which delivered approximately 2 g plant sterols/stanols. MAIN OUTCOME MEASURE: Changes in diet, body weight, and serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were measured. STATISTICAL ANALYSIS PERFORMED: Changes in dietary and biochemical outcomes were assessed using Student's t test. For nonnormally distributed data, Wilcoxon signed rank test was used, and Mann-Whitney U tests were conducted to determine the proportion of subjects reaching defined goals. The number needed to treat index was used to report effectiveness of the intervention. RESULTS: Five of 14 subjects in the intervention group compared with 0 of 11 in the control group achieved a reduction in serum cholesterol of >/=15% (P <.05). Using the number needed to treat index, for each 2.8 patients counseled with routine prescription of plant sterols/stanols, one additional patient would obtain a reduction in cholesterol by >/=15% compared with conventional management. This was achieved without any detrimental effects on the dietary fatty acid profile. CONCLUSIONS: Routine prescription of margarine containing plant sterol/stanol is an effective strategy in the management of hypercholesterolemic patients in the clinical setting. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/15635344/Plant_sterol/stanol_prescription_is_an_effective_treatment_strategy_for_managing_hypercholesterolemia_in_outpatient_clinical_practice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002822304016992 DB - PRIME DP - Unbound Medicine ER -