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Bronchiolitis obliterans in children.
Pediatr Pulmonol 2005; 39(3):193-208PP

Abstract

Bronchiolitis obliterans (BO) in children is a relatively rare diagnosis. The increase in lung and bone marrow transplantation in children, however, has led to a heightened interest in BO, as this is one of the important complications of those procedures. This article will discuss BO as an entity that can follow any of several illnesses or toxic exposures, in addition to following allogeneic lung or bone marrow transplantation. The complex and incompletely understood pathology, pathogenesis, and molecular pathology involved in BO remain the subject of ongoing investigations. As the prognosis for BO is uncertain and treatment is often unsuccessful, the continued need for the recognition of surrogate markers for BO in patients at risk and the development of better forms of therapy are paramount. This review will describe our current understanding of BO, and will call attention to those research areas that require continuing efforts in order to prevent or treat this entity.

Authors+Show Affiliations

Division of Pediatric Pulmonology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. geoffrey.kurland@chp.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15635614

Citation

Kurland, Geoffrey, and Peter Michelson. "Bronchiolitis Obliterans in Children." Pediatric Pulmonology, vol. 39, no. 3, 2005, pp. 193-208.
Kurland G, Michelson P. Bronchiolitis obliterans in children. Pediatr Pulmonol. 2005;39(3):193-208.
Kurland, G., & Michelson, P. (2005). Bronchiolitis obliterans in children. Pediatric Pulmonology, 39(3), pp. 193-208.
Kurland G, Michelson P. Bronchiolitis Obliterans in Children. Pediatr Pulmonol. 2005;39(3):193-208. PubMed PMID: 15635614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchiolitis obliterans in children. AU - Kurland,Geoffrey, AU - Michelson,Peter, PY - 2005/1/7/pubmed PY - 2005/7/1/medline PY - 2005/1/7/entrez SP - 193 EP - 208 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 39 IS - 3 N2 - Bronchiolitis obliterans (BO) in children is a relatively rare diagnosis. The increase in lung and bone marrow transplantation in children, however, has led to a heightened interest in BO, as this is one of the important complications of those procedures. This article will discuss BO as an entity that can follow any of several illnesses or toxic exposures, in addition to following allogeneic lung or bone marrow transplantation. The complex and incompletely understood pathology, pathogenesis, and molecular pathology involved in BO remain the subject of ongoing investigations. As the prognosis for BO is uncertain and treatment is often unsuccessful, the continued need for the recognition of surrogate markers for BO in patients at risk and the development of better forms of therapy are paramount. This review will describe our current understanding of BO, and will call attention to those research areas that require continuing efforts in order to prevent or treat this entity. SN - 8755-6863 UR - https://www.unboundmedicine.com/medline/citation/15635614/Bronchiolitis_obliterans_in_children_ L2 - https://doi.org/10.1002/ppul.20145 DB - PRIME DP - Unbound Medicine ER -