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Leptospirosis among schoolchildren of the Andaman & Nicobar Islands, India: low levels of morbidity and mortality among pre-exposed children during an epidemic.
Epidemiol Infect. 2004 Dec; 132(6):1115-20.EI

Abstract

Leptospirosis is an important public health problem in the Andaman Islands. The disease is being increasingly reported among children and adolescents in recent times. An attempt was made to find out the level of exposure to leptospires, to estimate the incidence of infection and to identity the risk factors for acquiring infection among children. A sample of 1544 schoolchildren was selected. Presence of anti-leptospiral antibodies was tested using the microscopic agglutination test (MAT). Students were interviewed for behavioural factors. In total, 341 (221 seronegative and 120 seropositive) students were followed up clinically and serologically during a subsequent outbreak. An overall seropositivity rate of 23.6% (95% CI 21.54-25.81) was observed. Infection rate was 33.5% among seronegatives whereas re-infection rate was 16.7% among seropositives during the outbreak that occurred 1 month after the first sample collection. Morbidity and mortality were found to be higher among seronegative individuals than seropositives. More than 90% of leptospiral infections were found to be subclinical or unnoticed. The high level of exposure among the children results in high infection rates and because they have less previous exposure than adults, they do not have sufficient protection to resist clinical illness during outbreaks.

Authors+Show Affiliations

National Leptospirosis Reference Centre, Regional Medical Research Centre (Indian Council of Medical Research), Port Blair, Andaman & Nicobar Islands, India. vij@rmrc.res.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15635969

Citation

Vijayachari, P, et al. "Leptospirosis Among Schoolchildren of the Andaman & Nicobar Islands, India: Low Levels of Morbidity and Mortality Among Pre-exposed Children During an Epidemic." Epidemiology and Infection, vol. 132, no. 6, 2004, pp. 1115-20.
Vijayachari P, Sugunan AP, Murhekar MV, et al. Leptospirosis among schoolchildren of the Andaman & Nicobar Islands, India: low levels of morbidity and mortality among pre-exposed children during an epidemic. Epidemiol Infect. 2004;132(6):1115-20.
Vijayachari, P., Sugunan, A. P., Murhekar, M. V., Sharma, S., & Sehgal, S. C. (2004). Leptospirosis among schoolchildren of the Andaman & Nicobar Islands, India: low levels of morbidity and mortality among pre-exposed children during an epidemic. Epidemiology and Infection, 132(6), 1115-20.
Vijayachari P, et al. Leptospirosis Among Schoolchildren of the Andaman & Nicobar Islands, India: Low Levels of Morbidity and Mortality Among Pre-exposed Children During an Epidemic. Epidemiol Infect. 2004;132(6):1115-20. PubMed PMID: 15635969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptospirosis among schoolchildren of the Andaman & Nicobar Islands, India: low levels of morbidity and mortality among pre-exposed children during an epidemic. AU - Vijayachari,P, AU - Sugunan,A P, AU - Murhekar,M V, AU - Sharma,S, AU - Sehgal,S C, PY - 2005/1/8/pubmed PY - 2005/1/27/medline PY - 2005/1/8/entrez SP - 1115 EP - 20 JF - Epidemiology and infection JO - Epidemiol Infect VL - 132 IS - 6 N2 - Leptospirosis is an important public health problem in the Andaman Islands. The disease is being increasingly reported among children and adolescents in recent times. An attempt was made to find out the level of exposure to leptospires, to estimate the incidence of infection and to identity the risk factors for acquiring infection among children. A sample of 1544 schoolchildren was selected. Presence of anti-leptospiral antibodies was tested using the microscopic agglutination test (MAT). Students were interviewed for behavioural factors. In total, 341 (221 seronegative and 120 seropositive) students were followed up clinically and serologically during a subsequent outbreak. An overall seropositivity rate of 23.6% (95% CI 21.54-25.81) was observed. Infection rate was 33.5% among seronegatives whereas re-infection rate was 16.7% among seropositives during the outbreak that occurred 1 month after the first sample collection. Morbidity and mortality were found to be higher among seronegative individuals than seropositives. More than 90% of leptospiral infections were found to be subclinical or unnoticed. The high level of exposure among the children results in high infection rates and because they have less previous exposure than adults, they do not have sufficient protection to resist clinical illness during outbreaks. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/15635969/Leptospirosis_among_schoolchildren_of_the_Andaman_&_Nicobar_Islands_India:_low_levels_of_morbidity_and_mortality_among_pre_exposed_children_during_an_epidemic_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15635969.ui DB - PRIME DP - Unbound Medicine ER -