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[The apolipoprotein E polymorphism in age related macular degeneration].
Klin Oczna. 2004; 106(3 Suppl):427-8.KO

Abstract

PURPOSE

The aim of the study was to evaluate association of apo E polymorphism with AMD.

MATERIAL AND METHODS

The included participants of this study were: 45 patients aged 60 to 71 (mean age 66.2 +/- 3.6), treated because of AMD. Genomic DNA was extracted from peripheral blood leukocytes, and the subsequent analysis of apo E genotypes was performed by polymerase chain reaction (PCR).

RESULTS

In our study the allele frequencies in control group of patients weresimilar to the apo E allele distribution presented by other authors in Caucasian populations. We have not found significant differences between AMD and control group patients for apo (E) genotype or allele frequency. Compared with control group (epsilon4 -13.6%, epsilon2 -2.27%), the frequency of epsilon4 allele was not significantly decreased (11.11%) and epsilon2 allele frequency (7.77%) increased in AMD patients.

CONCLUSIONS

The results of our present study have not indicate a significant association between AMD development and apo E allele frequency, in our studied population of AMD patients.

Authors+Show Affiliations

Zakładu Patofizjologii Katedry Patofizjologii i Endokrynologii Slaskiej Akademii Medycznej.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

pol

PubMed ID

15636224

Citation

Nowak, Mariusz, et al. "[The Apolipoprotein E Polymorphism in Age Related Macular Degeneration]." Klinika Oczna, vol. 106, no. 3 Suppl, 2004, pp. 427-8.
Nowak M, Swietochowska E, Szapska B, et al. [The apolipoprotein E polymorphism in age related macular degeneration]. Klin Oczna. 2004;106(3 Suppl):427-8.
Nowak, M., Swietochowska, E., Szapska, B., Marek, B., Wielkoszyński, T., Kozioł, H., Klimek, J., Kajdaniuk, D., Kos-Kudła, B., Ostrowska, Z., Karpe, J., Głogowska-Szelag, J., & Siemińska, L. (2004). [The apolipoprotein E polymorphism in age related macular degeneration]. Klinika Oczna, 106(3 Suppl), 427-8.
Nowak M, et al. [The Apolipoprotein E Polymorphism in Age Related Macular Degeneration]. Klin Oczna. 2004;106(3 Suppl):427-8. PubMed PMID: 15636224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The apolipoprotein E polymorphism in age related macular degeneration]. AU - Nowak,Mariusz, AU - Swietochowska,Elzbieta, AU - Szapska,Bozena, AU - Marek,Bogdan, AU - Wielkoszyński,Tomasz, AU - Kozioł,Henryk, AU - Klimek,Joanna, AU - Kajdaniuk,Dariusz, AU - Kos-Kudła,Beata, AU - Ostrowska,Zofia, AU - Karpe,Jacek, AU - Głogowska-Szelag,Joanna, AU - Siemińska,Lucyna, PY - 2005/1/8/pubmed PY - 2005/4/6/medline PY - 2005/1/8/entrez SP - 427 EP - 8 JF - Klinika oczna JO - Klin Oczna VL - 106 IS - 3 Suppl N2 - PURPOSE: The aim of the study was to evaluate association of apo E polymorphism with AMD. MATERIAL AND METHODS: The included participants of this study were: 45 patients aged 60 to 71 (mean age 66.2 +/- 3.6), treated because of AMD. Genomic DNA was extracted from peripheral blood leukocytes, and the subsequent analysis of apo E genotypes was performed by polymerase chain reaction (PCR). RESULTS: In our study the allele frequencies in control group of patients weresimilar to the apo E allele distribution presented by other authors in Caucasian populations. We have not found significant differences between AMD and control group patients for apo (E) genotype or allele frequency. Compared with control group (epsilon4 -13.6%, epsilon2 -2.27%), the frequency of epsilon4 allele was not significantly decreased (11.11%) and epsilon2 allele frequency (7.77%) increased in AMD patients. CONCLUSIONS: The results of our present study have not indicate a significant association between AMD development and apo E allele frequency, in our studied population of AMD patients. SN - 0023-2157 UR - https://www.unboundmedicine.com/medline/citation/15636224/[The_apolipoprotein_E_polymorphism_in_age_related_macular_degeneration]_ L2 - https://www.diseaseinfosearch.org/result/4401 DB - PRIME DP - Unbound Medicine ER -