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The allele interaction between apolipoprotein epsilon2 and epsilon4 in Taiwanese Alzheimer's disease patients.
Acta Psychiatr Scand. 2005 Jan; 111(1):38-43.AP

Abstract

OBJECTIVE

This study aimed to determine the impact of the present of apolipoprotein epsilon (Apoepsilon) 2 on the relationship between Apoepsilon4 and Alzheimer's disease (AD).

METHOD

We examined ApoE genotypes in 428 Taiwanese patients with AD and 807 controls; all participants were older than 65 years.

RESULTS

The allele frequency of Apoepsilon4 was greater in AD patients than controls, but significantly lower than in Caucasians. The presence of an epsilon2 allele alone was not associated with lower risk for AD, but the presence of an epsilon2 allele was associated with an epsilon4 allele frequency similar to that of controls.

CONCLUSION

The low allele frequency of epsilon4 in persons with an epsilon2 allele suggests that this may be part of the protective effect of epsilon2 against AD.

Authors+Show Affiliations

Department of Psychiatry, Military Kaohsiung General Hospital, Chung Cheng, Kaohsiung, Taiwan. forwey@ksts.seed.net.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15636592

Citation

Lung, F-W, et al. "The Allele Interaction Between Apolipoprotein Epsilon2 and Epsilon4 in Taiwanese Alzheimer's Disease Patients." Acta Psychiatrica Scandinavica, vol. 111, no. 1, 2005, pp. 38-43.
Lung FW, Yen YC, Chou LJ, et al. The allele interaction between apolipoprotein epsilon2 and epsilon4 in Taiwanese Alzheimer's disease patients. Acta Psychiatr Scand. 2005;111(1):38-43.
Lung, F. W., Yen, Y. C., Chou, L. J., Hong, C. J., & Wu, C. K. (2005). The allele interaction between apolipoprotein epsilon2 and epsilon4 in Taiwanese Alzheimer's disease patients. Acta Psychiatrica Scandinavica, 111(1), 38-43.
Lung FW, et al. The Allele Interaction Between Apolipoprotein Epsilon2 and Epsilon4 in Taiwanese Alzheimer's Disease Patients. Acta Psychiatr Scand. 2005;111(1):38-43. PubMed PMID: 15636592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The allele interaction between apolipoprotein epsilon2 and epsilon4 in Taiwanese Alzheimer's disease patients. AU - Lung,F-W, AU - Yen,Y-C, AU - Chou,L-J, AU - Hong,C-J, AU - Wu,C-K, PY - 2005/1/8/pubmed PY - 2005/7/9/medline PY - 2005/1/8/entrez SP - 38 EP - 43 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 111 IS - 1 N2 - OBJECTIVE: This study aimed to determine the impact of the present of apolipoprotein epsilon (Apoepsilon) 2 on the relationship between Apoepsilon4 and Alzheimer's disease (AD). METHOD: We examined ApoE genotypes in 428 Taiwanese patients with AD and 807 controls; all participants were older than 65 years. RESULTS: The allele frequency of Apoepsilon4 was greater in AD patients than controls, but significantly lower than in Caucasians. The presence of an epsilon2 allele alone was not associated with lower risk for AD, but the presence of an epsilon2 allele was associated with an epsilon4 allele frequency similar to that of controls. CONCLUSION: The low allele frequency of epsilon4 in persons with an epsilon2 allele suggests that this may be part of the protective effect of epsilon2 against AD. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/15636592/The_allele_interaction_between_apolipoprotein_epsilon2_and_epsilon4_in_Taiwanese_Alzheimer's_disease_patients_ L2 - https://doi.org/10.1111/j.1600-0447.2004.00394.x DB - PRIME DP - Unbound Medicine ER -