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Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study.
Wien Med Wochenschr 2004; 154(21-22):498-507WM

Abstract

In a controlled, double blind, randomized multicentre study, the efficacy and safety of the topical comfrey product Traumaplant (10% active ingredient of a 2.5:1 aqueous ethanolic pressed juice of freshly harvested, cultivated comfrey herb (Symphytum x uplandicum NYMAN), corresponding to 25 g of fresh herb per 100 g of cream; n = 104) was tested against a 1% product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n = 99) in 203 patients with acute ankle distortion. With the high concentration, decrease of the scores for pain on active motion, pain at rest and functional impairment was highly significant and clinically relevant on days T3-4 as well as T7 (p < 0.001). Amelioration of swellings as compared to reference was also significant on day 3-4 (p < 0.01). Efficacy was judged good to excellent in 85.6% of cases with verum and in 65.7% of cases with reference on day 3-4. Overall tolerability was excellent.

Authors+Show Affiliations

Department for Sports Medicine and Rehabilitation, 2nd Medical Faculty of the Charles University Prague, Prague. miroslav.kucera@lfmotol.cuni.cz

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

15638067

Citation

Kucera, Miroslav, et al. "Efficacy and Safety of Topically Applied Symphytum Herb Extract Cream in the Treatment of Ankle Distortion: Results of a Randomized Controlled Clinical Double Blind Study." Wiener Medizinische Wochenschrift (1946), vol. 154, no. 21-22, 2004, pp. 498-507.
Kucera M, Barna M, Horácek O, et al. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. Wien Med Wochenschr. 2004;154(21-22):498-507.
Kucera, M., Barna, M., Horácek, O., Kováriková, J., & Kucera, A. (2004). Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. Wiener Medizinische Wochenschrift (1946), 154(21-22), pp. 498-507.
Kucera M, et al. Efficacy and Safety of Topically Applied Symphytum Herb Extract Cream in the Treatment of Ankle Distortion: Results of a Randomized Controlled Clinical Double Blind Study. Wien Med Wochenschr. 2004;154(21-22):498-507. PubMed PMID: 15638067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. AU - Kucera,Miroslav, AU - Barna,Milos, AU - Horácek,Ondrej, AU - Kováriková,Jaroslava, AU - Kucera,Alexander, PY - 2005/1/11/pubmed PY - 2005/4/9/medline PY - 2005/1/11/entrez SP - 498 EP - 507 JF - Wiener medizinische Wochenschrift (1946) JO - Wien Med Wochenschr VL - 154 IS - 21-22 N2 - In a controlled, double blind, randomized multicentre study, the efficacy and safety of the topical comfrey product Traumaplant (10% active ingredient of a 2.5:1 aqueous ethanolic pressed juice of freshly harvested, cultivated comfrey herb (Symphytum x uplandicum NYMAN), corresponding to 25 g of fresh herb per 100 g of cream; n = 104) was tested against a 1% product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n = 99) in 203 patients with acute ankle distortion. With the high concentration, decrease of the scores for pain on active motion, pain at rest and functional impairment was highly significant and clinically relevant on days T3-4 as well as T7 (p < 0.001). Amelioration of swellings as compared to reference was also significant on day 3-4 (p < 0.01). Efficacy was judged good to excellent in 85.6% of cases with verum and in 65.7% of cases with reference on day 3-4. Overall tolerability was excellent. SN - 0043-5341 UR - https://www.unboundmedicine.com/medline/citation/15638067/Efficacy_and_safety_of_topically_applied_Symphytum_herb_extract_cream_in_the_treatment_of_ankle_distortion:_results_of_a_randomized_controlled_clinical_double_blind_study_ L2 - https://medlineplus.gov/ankleinjuriesanddisorders.html DB - PRIME DP - Unbound Medicine ER -