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Marked changes in erythrocyte antioxidants and lipid peroxidation levels of rats exposed to acute, repeated and chronic restraint stress.
Pharmazie. 2004 Dec; 59(12):961-4.P

Abstract

The aim of this study was to investigate the effects of acute, repeated and chronic restraint stress on the antioxidant status and lipid peroxidation. For this purpose, 48 male Wistar rats, aged three months were used in this study. Rats were separated into six groups as follows; control (C), acute stress (AS), restrained for 7 days (1 h/day) (RS), restrained for 21 days (1 h/day) (CS1), restrained for 28 days (1 h/day) (CS2) and restrained for 21 days (1 h/day) and allowed to recovery for 7 days (CS3). Copper, zinc-superoxide dismutase (Cu, Zn-SOD), catalase (CAT) and selenium-dependent glutathione peroxidase (Se-GSH-Px) activities, corticosterone, reduced glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) levels were measured in blood samples. Corticosterone levels of all groups were found to be elevated after stress compared to group C. Cu, Zn-SOD activity was lower in all stress groups than in group C. CAT and Se-GSH-Px activities were increased in all stress groups. All stress models decreased GSH levels except for the CS3 group. TBARS levels were higher in stress groups than in C group except for AS group. The highest corticosterone level, CAT and Se-GSH-Px activity and TBARS level were seen in group RS. The lowest Cu, Zn-SOD activity and GSH level were seen in group CS2. These results may have an important implication for impaired erythrocyte antioxidant enzyme activities and glutathione levels resulting from exposure to different stress models (acute, repeated and chronic restraint stress).

Authors+Show Affiliations

Department of Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15638087

Citation

Sahin, E, et al. "Marked Changes in Erythrocyte Antioxidants and Lipid Peroxidation Levels of Rats Exposed to Acute, Repeated and Chronic Restraint Stress." Die Pharmazie, vol. 59, no. 12, 2004, pp. 961-4.
Sahin E, Gümüşlü S, Oztürk O, et al. Marked changes in erythrocyte antioxidants and lipid peroxidation levels of rats exposed to acute, repeated and chronic restraint stress. Pharmazie. 2004;59(12):961-4.
Sahin, E., Gümüşlü, S., Oztürk, O., Abidin, I., Yargiçoğlu, P., & Ağar, A. (2004). Marked changes in erythrocyte antioxidants and lipid peroxidation levels of rats exposed to acute, repeated and chronic restraint stress. Die Pharmazie, 59(12), 961-4.
Sahin E, et al. Marked Changes in Erythrocyte Antioxidants and Lipid Peroxidation Levels of Rats Exposed to Acute, Repeated and Chronic Restraint Stress. Pharmazie. 2004;59(12):961-4. PubMed PMID: 15638087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marked changes in erythrocyte antioxidants and lipid peroxidation levels of rats exposed to acute, repeated and chronic restraint stress. AU - Sahin,E, AU - Gümüşlü,S, AU - Oztürk,O, AU - Abidin,I, AU - Yargiçoğlu,P, AU - Ağar,A, PY - 2005/1/11/pubmed PY - 2005/2/8/medline PY - 2005/1/11/entrez SP - 961 EP - 4 JF - Die Pharmazie JO - Pharmazie VL - 59 IS - 12 N2 - The aim of this study was to investigate the effects of acute, repeated and chronic restraint stress on the antioxidant status and lipid peroxidation. For this purpose, 48 male Wistar rats, aged three months were used in this study. Rats were separated into six groups as follows; control (C), acute stress (AS), restrained for 7 days (1 h/day) (RS), restrained for 21 days (1 h/day) (CS1), restrained for 28 days (1 h/day) (CS2) and restrained for 21 days (1 h/day) and allowed to recovery for 7 days (CS3). Copper, zinc-superoxide dismutase (Cu, Zn-SOD), catalase (CAT) and selenium-dependent glutathione peroxidase (Se-GSH-Px) activities, corticosterone, reduced glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) levels were measured in blood samples. Corticosterone levels of all groups were found to be elevated after stress compared to group C. Cu, Zn-SOD activity was lower in all stress groups than in group C. CAT and Se-GSH-Px activities were increased in all stress groups. All stress models decreased GSH levels except for the CS3 group. TBARS levels were higher in stress groups than in C group except for AS group. The highest corticosterone level, CAT and Se-GSH-Px activity and TBARS level were seen in group RS. The lowest Cu, Zn-SOD activity and GSH level were seen in group CS2. These results may have an important implication for impaired erythrocyte antioxidant enzyme activities and glutathione levels resulting from exposure to different stress models (acute, repeated and chronic restraint stress). SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15638087/Marked_changes_in_erythrocyte_antioxidants_and_lipid_peroxidation_levels_of_rats_exposed_to_acute_repeated_and_chronic_restraint_stress_ L2 - http://amigo.geneontology.org/amigo/reference/PMID:15638087 DB - PRIME DP - Unbound Medicine ER -