Tags

Type your tag names separated by a space and hit enter

Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome.
Clin Endocrinol (Oxf). 2005 Jan; 62(1):37-43.CE

Abstract

OBJECTIVE

Women with polycystic ovary syndrome (PCOS) carry a number of cardiovascular risk factors and are considered to be at increased risk for atherosclerosis. Elevated concentrations of advanced glycation end-products (AGE), which exert their effects through interaction with specific receptors (RAGE), have been implicated in the cellular and tissue damage during atherosclerotic processes.

DESIGN/PATIENTS

We investigated serum AGE levels in 29 young women with PCOS as well as the expression of their receptor, RAGE, in circulating monocytes and compared them levels with 22 healthy control women.

MEASUREMENTS/RESULTS

Women with PCOS had higher levels of serum AGE proteins compared to healthy individuals (9.81 +/- 0.16 vs. 5.11 +/- 0.16, P < 0.0001), and increased RAGE expression was observed in monocytes of PCOS women compared to controls (30.91 +/- 10.11 vs. 7.97 +/- 2.61, P < 0.02). A positive correlation was observed between AGE proteins and testosterone (T) levels (r = 0.73, P < 0.0001). The correlation between AGE proteins and T levels remained high (partial correlation coefficient = 0.61, P = 0.0001) after controlling for body mass index (BMI), insulin levels and the area under the curve for glucose (AUCGLU) during an oral glucose tolerance test (OGTT). A positive correlation was also observed between AGE proteins and the free androgen index (FAI) (r = 0.58, P < 0.0001), waist-to-hip ratio (WHR) (r = 0.31, P < 0.02), insulin (r = 0.46, P < 0.001), homeostasis model assessment (HOMA) (r = 0.47, P < 0.0001), AUCGLU (r = 0.52, P < 0.002) and RAGE (r = 0.59, P < 0.01). A negative correlation was observed between AGE proteins and glucose/insulin ratio (GLU/INS) (r = -0.35, P < 0.01), and the quantitative insulin sensitivity check index (QUICKI) (r =-0.50, P < 0.01). In multiple regression analysis T was the only independent predictor of AGE levels (P < 0.0001, b = 0.044) between BMI, insulin, SHBG and AUCGLU (adjusted R2 = 0.59, F = 44.41, P < 0.0001).

CONCLUSION

These data clearly demonstrate, for the first time, that PCOS women without overt hyperglycaemia have increased AGE levels and elevated RAGE expression when compared with controls.

Authors+Show Affiliations

First Department of Internal Medicine, Endocrine Section, Aretaieion Hospital, University of Athens Medical School, Athens, Greece. akandara@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15638868

Citation

Diamanti-Kandarakis, Evanthia, et al. "Increased Levels of Serum Advanced Glycation End-products in Women With Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 62, no. 1, 2005, pp. 37-43.
Diamanti-Kandarakis E, Piperi C, Kalofoutis A, et al. Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2005;62(1):37-43.
Diamanti-Kandarakis, E., Piperi, C., Kalofoutis, A., & Creatsas, G. (2005). Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome. Clinical Endocrinology, 62(1), 37-43.
Diamanti-Kandarakis E, et al. Increased Levels of Serum Advanced Glycation End-products in Women With Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 2005;62(1):37-43. PubMed PMID: 15638868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome. AU - Diamanti-Kandarakis,Evanthia, AU - Piperi,Christina, AU - Kalofoutis,Anastasios, AU - Creatsas,George, PY - 2005/1/11/pubmed PY - 2005/4/12/medline PY - 2005/1/11/entrez SP - 37 EP - 43 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 62 IS - 1 N2 - OBJECTIVE: Women with polycystic ovary syndrome (PCOS) carry a number of cardiovascular risk factors and are considered to be at increased risk for atherosclerosis. Elevated concentrations of advanced glycation end-products (AGE), which exert their effects through interaction with specific receptors (RAGE), have been implicated in the cellular and tissue damage during atherosclerotic processes. DESIGN/PATIENTS: We investigated serum AGE levels in 29 young women with PCOS as well as the expression of their receptor, RAGE, in circulating monocytes and compared them levels with 22 healthy control women. MEASUREMENTS/RESULTS: Women with PCOS had higher levels of serum AGE proteins compared to healthy individuals (9.81 +/- 0.16 vs. 5.11 +/- 0.16, P < 0.0001), and increased RAGE expression was observed in monocytes of PCOS women compared to controls (30.91 +/- 10.11 vs. 7.97 +/- 2.61, P < 0.02). A positive correlation was observed between AGE proteins and testosterone (T) levels (r = 0.73, P < 0.0001). The correlation between AGE proteins and T levels remained high (partial correlation coefficient = 0.61, P = 0.0001) after controlling for body mass index (BMI), insulin levels and the area under the curve for glucose (AUCGLU) during an oral glucose tolerance test (OGTT). A positive correlation was also observed between AGE proteins and the free androgen index (FAI) (r = 0.58, P < 0.0001), waist-to-hip ratio (WHR) (r = 0.31, P < 0.02), insulin (r = 0.46, P < 0.001), homeostasis model assessment (HOMA) (r = 0.47, P < 0.0001), AUCGLU (r = 0.52, P < 0.002) and RAGE (r = 0.59, P < 0.01). A negative correlation was observed between AGE proteins and glucose/insulin ratio (GLU/INS) (r = -0.35, P < 0.01), and the quantitative insulin sensitivity check index (QUICKI) (r =-0.50, P < 0.01). In multiple regression analysis T was the only independent predictor of AGE levels (P < 0.0001, b = 0.044) between BMI, insulin, SHBG and AUCGLU (adjusted R2 = 0.59, F = 44.41, P < 0.0001). CONCLUSION: These data clearly demonstrate, for the first time, that PCOS women without overt hyperglycaemia have increased AGE levels and elevated RAGE expression when compared with controls. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15638868/Increased_levels_of_serum_advanced_glycation_end_products_in_women_with_polycystic_ovary_syndrome_ L2 - https://doi.org/10.1111/j.1365-2265.2004.02170.x DB - PRIME DP - Unbound Medicine ER -