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Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes.
Postgrad Med J. 2005 Jan; 81(951):1-6.PM

Abstract

The worldwide prevalence of type 2 diabetes mellitus has reached epidemic proportions. The so-called traditional risk factors cannot fully explain the excessive cardiovascular disease risk of type 2 diabetic patients. Numerous studies indicate that postprandial metabolic derangements, most notably hyperglycaemia and hypertriglyceridaemia, which are exaggerated and prolonged in type 2 diabetes, are important cardiovascular disease risk factors since they induce oxidative stress and endothelial dysfunctions. This review discusses the current evidence showing that postprandial dysmetabolism may indeed constitute an important cardiovascular disease risk factor as well as the mechanisms underlying this association. Finally, some possible therapeutic options and recommendations for future research are discussed.

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Authors+Show Affiliations

Tushuizen ME
Department of Endocrinology/Diabetes Centre, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands. m.tushuizen@vumc.nl
Diamant M
No affiliation info available
Heine RJ
No affiliation info available

MeSH

Cardiovascular DiseasesDiabetes Mellitus, Type 2Diabetic AngiopathiesHumansHyperglycemiaHypertriglyceridemiaPostprandial PeriodRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15640422

Citation

Tushuizen, M E., et al. "Postprandial Dysmetabolism and Cardiovascular Disease in Type 2 Diabetes." Postgraduate Medical Journal, vol. 81, no. 951, 2005, pp. 1-6.
Tushuizen ME, Diamant M, Heine RJ. Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. Postgrad Med J. 2005;81(951):1-6.
Tushuizen, M. E., Diamant, M., & Heine, R. J. (2005). Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. Postgraduate Medical Journal, 81(951), 1-6.
Tushuizen ME, Diamant M, Heine RJ. Postprandial Dysmetabolism and Cardiovascular Disease in Type 2 Diabetes. Postgrad Med J. 2005;81(951):1-6. PubMed PMID: 15640422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes. AU - Tushuizen,M E, AU - Diamant,M, AU - Heine,R J, PY - 2005/1/11/pubmed PY - 2005/5/10/medline PY - 2005/1/11/entrez SP - 1 EP - 6 JF - Postgraduate medical journal JO - Postgrad Med J VL - 81 IS - 951 N2 - The worldwide prevalence of type 2 diabetes mellitus has reached epidemic proportions. The so-called traditional risk factors cannot fully explain the excessive cardiovascular disease risk of type 2 diabetic patients. Numerous studies indicate that postprandial metabolic derangements, most notably hyperglycaemia and hypertriglyceridaemia, which are exaggerated and prolonged in type 2 diabetes, are important cardiovascular disease risk factors since they induce oxidative stress and endothelial dysfunctions. This review discusses the current evidence showing that postprandial dysmetabolism may indeed constitute an important cardiovascular disease risk factor as well as the mechanisms underlying this association. Finally, some possible therapeutic options and recommendations for future research are discussed. SN - 0032-5473 UR - https://www.unboundmedicine.com/medline/citation/15640422/Postprandial_dysmetabolism_and_cardiovascular_disease_in_type_2_diabetes_ DB - PRIME DP - Unbound Medicine ER -