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Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.
Neuroreport 2004; 15(15):2381-5N

Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia.

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    Authors+Show Affiliations

    Hayakawa K
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka City, Fukuoka, 814-0180, Japan.
    Mishima K
    No affiliation info available
    Abe K
    No affiliation info available
    Hasebe N
    No affiliation info available
    Takamatsu F
    No affiliation info available
    Yasuda H
    No affiliation info available
    Ikeda T
    No affiliation info available
    Inui K
    No affiliation info available
    Egashira N
    No affiliation info available
    Iwasaki K
    No affiliation info available
    Fujiwara M
    No affiliation info available

    MeSH

    Analysis of VarianceAnimalsBody TemperatureBrain InfarctionCannabidiolDisease Models, AnimalDose-Response Relationship, DrugDronabinolDrug InteractionsFeverInfarction, Middle Cerebral ArteryMaleMiceNeuroprotective AgentsPiperidinesPyrazolesReceptor, Cannabinoid, CB1RimonabantTetrazolium SaltsTime Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15640760

    Citation

    Hayakawa, Kazuhide, et al. "Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism." Neuroreport, vol. 15, no. 15, 2004, pp. 2381-5.
    Hayakawa K, Mishima K, Abe K, et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004;15(15):2381-5.
    Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., ... Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport, 15(15), pp. 2381-5.
    Hayakawa K, et al. Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism. Neuroreport. 2004 Oct 25;15(15):2381-5. PubMed PMID: 15640760.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Abe,Kohji, AU - Hasebe,Nobuyoshi, AU - Takamatsu,Fumie, AU - Yasuda,Hiromi, AU - Ikeda,Tomoaki, AU - Inui,Keiichiro, AU - Egashira,Nobuaki, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, PY - 2005/1/11/pubmed PY - 2005/4/9/medline PY - 2005/1/11/entrez SP - 2381 EP - 5 JF - Neuroreport JO - Neuroreport VL - 15 IS - 15 N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/15640760/Cannabidiol_prevents_infarction_via_the_non_CB1_cannabinoid_receptor_mechanism_ L2 - http://Insights.ovid.com/pubmed?pmid=15640760 DB - PRIME DP - Unbound Medicine ER -