Citation
Hayakawa, Kazuhide, et al. "Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism." Neuroreport, vol. 15, no. 15, 2004, pp. 2381-5.
Hayakawa K, Mishima K, Abe K, et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004;15(15):2381-5.
Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., Ikeda, T., Inui, K., Egashira, N., Iwasaki, K., & Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport, 15(15), 2381-5.
Hayakawa K, et al. Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism. Neuroreport. 2004 Oct 25;15(15):2381-5. PubMed PMID: 15640760.
TY - JOUR
T1 - Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.
AU - Hayakawa,Kazuhide,
AU - Mishima,Kenichi,
AU - Abe,Kohji,
AU - Hasebe,Nobuyoshi,
AU - Takamatsu,Fumie,
AU - Yasuda,Hiromi,
AU - Ikeda,Tomoaki,
AU - Inui,Keiichiro,
AU - Egashira,Nobuaki,
AU - Iwasaki,Katsunori,
AU - Fujiwara,Michihiro,
PY - 2005/1/11/pubmed
PY - 2005/4/9/medline
PY - 2005/1/11/entrez
SP - 2381
EP - 5
JF - Neuroreport
JO - Neuroreport
VL - 15
IS - 15
N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia.
SN - 0959-4965
UR - https://www.unboundmedicine.com/medline/citation/15640760/Cannabidiol_prevents_infarction_via_the_non_CB1_cannabinoid_receptor_mechanism_
L2 - https://doi.org/10.1097/00001756-200410250-00016
DB - PRIME
DP - Unbound Medicine
ER -