TY - JOUR T1 - Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Abe,Kohji, AU - Hasebe,Nobuyoshi, AU - Takamatsu,Fumie, AU - Yasuda,Hiromi, AU - Ikeda,Tomoaki, AU - Inui,Keiichiro, AU - Egashira,Nobuaki, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, PY - 2005/1/11/pubmed PY - 2005/4/9/medline PY - 2005/1/11/entrez SP - 2381 EP - 5 JF - Neuroreport JO - Neuroreport VL - 15 IS - 15 N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/15640760/Cannabidiol_prevents_infarction_via_the_non_CB1_cannabinoid_receptor_mechanism_ L2 - https://doi.org/10.1097/00001756-200410250-00016 DB - PRIME DP - Unbound Medicine ER -