Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.

Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia.

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Authors+Show Affiliations

Hayakawa K

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka City, Fukuoka, 814-0180, Japan.

Source

Neuroreport 15:15 2004 Oct 25 pg 2381-5

MeSH

Analysis of Variance
Animals
Body Temperature
Brain Infarction
Cannabidiol
Disease Models, Animal
Dose-Response Relationship, Drug
Dronabinol
Drug Interactions
Fever
Infarction, Middle Cerebral Artery
Male
Mice
Neuroprotective Agents
Piperidines
Pyrazoles
Receptor, Cannabinoid, CB1
Rimonabant
Tetrazolium Salts
Time Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15640760

Citation

Hayakawa, Kazuhide, et al. "Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism." Neuroreport, vol. 15, no. 15, 2004, pp. 2381-5.

Hayakawa K, Mishima K, Abe K, et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004;15(15):2381-5.

Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., ... Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport, 15(15), pp. 2381-5.

Hayakawa K, et al. Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism. Neuroreport. 2004 Oct 25;15(15):2381-5. PubMed PMID: 15640760.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Abe,Kohji, AU - Hasebe,Nobuyoshi, AU - Takamatsu,Fumie, AU - Yasuda,Hiromi, AU - Ikeda,Tomoaki, AU - Inui,Keiichiro, AU - Egashira,Nobuaki, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, PY - 2005/1/11/pubmed PY - 2005/4/9/medline PY - 2005/1/11/entrez SP - 2381 EP - 5 JF - Neuroreport JO - Neuroreport VL - 15 IS - 15 N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/15640760/Cannabidiol_prevents_infarction_via_the_non_CB1_cannabinoid_receptor_mechanism_ L2 - http://Insights.ovid.com/pubmed?pmid=15640760 DB - PRIME DP - Unbound Medicine ER -

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