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Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism.

Abstract

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia.

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  • Authors+Show Affiliations

    ,

    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka City, Fukuoka, 814-0180, Japan.

    , , , , , , , , ,

    Source

    Neuroreport 15:15 2004 Oct 25 pg 2381-5

    MeSH

    Analysis of Variance
    Animals
    Body Temperature
    Brain Infarction
    Cannabidiol
    Disease Models, Animal
    Dose-Response Relationship, Drug
    Dronabinol
    Drug Interactions
    Fever
    Infarction, Middle Cerebral Artery
    Male
    Mice
    Neuroprotective Agents
    Piperidines
    Pyrazoles
    Receptor, Cannabinoid, CB1
    Rimonabant
    Tetrazolium Salts
    Time Factors

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15640760

    Citation

    Hayakawa, Kazuhide, et al. "Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism." Neuroreport, vol. 15, no. 15, 2004, pp. 2381-5.
    Hayakawa K, Mishima K, Abe K, et al. Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport. 2004;15(15):2381-5.
    Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., ... Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. Neuroreport, 15(15), pp. 2381-5.
    Hayakawa K, et al. Cannabidiol Prevents Infarction Via the non-CB1 Cannabinoid Receptor Mechanism. Neuroreport. 2004 Oct 25;15(15):2381-5. PubMed PMID: 15640760.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism. AU - Hayakawa,Kazuhide, AU - Mishima,Kenichi, AU - Abe,Kohji, AU - Hasebe,Nobuyoshi, AU - Takamatsu,Fumie, AU - Yasuda,Hiromi, AU - Ikeda,Tomoaki, AU - Inui,Keiichiro, AU - Egashira,Nobuaki, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, PY - 2005/1/11/pubmed PY - 2005/4/9/medline PY - 2005/1/11/entrez SP - 2381 EP - 5 JF - Neuroreport JO - Neuroreport VL - 15 IS - 15 N2 - Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Delta(9)-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Delta(9)-tetrahydrocannabinol but not cannabidiol were inhibited by SR141716, a cannabinoid CB1 receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Delta(9)-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SR141716. These results surely show that the neuroprotective effect of Delta(9)-tetrahydrocannabinol are via a CB1 receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CB1 blockade and of hypothermia. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/15640760/Cannabidiol_prevents_infarction_via_the_non_CB1_cannabinoid_receptor_mechanism_ L2 - http://Insights.ovid.com/pubmed?pmid=15640760 DB - PRIME DP - Unbound Medicine ER -