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Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans.
FEBS Lett. 2005 Jan 17; 579(2):549-53.FL

Abstract

Signals from germ and myoepithelial sheath cells initiate ovulation in Caenorhabditis elegans. The coordinated dilation and contraction of spermatheca lead to subsequent fertilization of oocyte. Either the dominant negative mutant pat-3 beta integrin or disruption of talin expression block ovulation. Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans. Role of beta pat-3 integrins in development and function of Caenorhabditis elegans muscles and gonads, suggesting that the interaction between the cell and the extracellular matrix (ECM) is also important for ovulation. Here, we report that integrin plays an essential role in fertility via IP(3) signaling. Sterility caused by RNAi of pat-3 and ECM molecules was suppressed by increased IP(3) signaling. Our data suggest that the cell-ECM interaction controls ovulation via IP(3) signaling.

Authors+Show Affiliations

Department of Biology, Baylor University, One Bear Place 97388, Waco, TX 76798-7388, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15642374

Citation

Xu, Xiaojian, et al. "Linking Integrin to IP(3) Signaling Is Important for Ovulation in Caenorhabditis Elegans." FEBS Letters, vol. 579, no. 2, 2005, pp. 549-53.
Xu X, Lee D, Shih HY, et al. Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans. FEBS Lett. 2005;579(2):549-53.
Xu, X., Lee, D., Shih, H. Y., Seo, S., Ahn, J., & Lee, M. (2005). Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans. FEBS Letters, 579(2), 549-53.
Xu X, et al. Linking Integrin to IP(3) Signaling Is Important for Ovulation in Caenorhabditis Elegans. FEBS Lett. 2005 Jan 17;579(2):549-53. PubMed PMID: 15642374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linking integrin to IP(3) signaling is important for ovulation in Caenorhabditis elegans. AU - Xu,Xiaojian, AU - Lee,Diana, AU - Shih,Hung-Ying, AU - Seo,Sehee, AU - Ahn,Jeong, AU - Lee,Myeongwoo, PY - 2004/10/06/received PY - 2004/12/08/revised PY - 2004/12/13/accepted PY - 2005/1/12/pubmed PY - 2005/3/16/medline PY - 2005/1/12/entrez SP - 549 EP - 53 JF - FEBS letters JO - FEBS Lett VL - 579 IS - 2 N2 - Signals from germ and myoepithelial sheath cells initiate ovulation in Caenorhabditis elegans. The coordinated dilation and contraction of spermatheca lead to subsequent fertilization of oocyte. Either the dominant negative mutant pat-3 beta integrin or disruption of talin expression block ovulation. Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans. Role of beta pat-3 integrins in development and function of Caenorhabditis elegans muscles and gonads, suggesting that the interaction between the cell and the extracellular matrix (ECM) is also important for ovulation. Here, we report that integrin plays an essential role in fertility via IP(3) signaling. Sterility caused by RNAi of pat-3 and ECM molecules was suppressed by increased IP(3) signaling. Our data suggest that the cell-ECM interaction controls ovulation via IP(3) signaling. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/15642374/Linking_integrin_to_IP_3__signaling_is_important_for_ovulation_in_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(04)01562-5 DB - PRIME DP - Unbound Medicine ER -