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Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome.
J Endocrinol. 2005 Jan; 184(1):233-9.JE

Abstract

To investigate whether the long-term administration of metformin or pioglitazone to women with polycystic ovary syndrome (PCOS) could induce changes in their hypothalamic dopaminergic (DA) tone and to analyze whether these changes correlated with modifications in insulin resistance, we originally studied 57 obese hyperinsulinemic, non-diabetic, insulin resistant women with PCOS, but only 34 completed the study. They were randomly divided into two groups: group one (n=17) received pioglitazone (30 mg/day) and group 2 (n=17) received metformin (850 mg, three times a day) over 24 weeks. All women were identically studied before (basal) and 6 months after (T6) drug administration, including clinical evaluations, a 2 h oral glucose tolerance test (75 g) (OGTT) for glucose and insulin measurements, followed a week later by a 2 h intravenous metoclopramide test (10 mg bolus) for prolactin (PRL) determinations. The areas under the insulin (AUC-insulin) and PRL (AUC-PRL) curves were calculated, along with the index of insulin resistance (HOMA-IR) and the indexes of insulin sensitivity (QUICKI and fasting glucose-insulin ratio). At baseline, women in both groups were of similar age, body weight, body mass index (BMI) and Ferriman-Gallwey hirsutism score (F-G score). At completion of the study, body weight and BMI remained unchanged but the F-G score significantly decreased. Fasting serum insulin concentrations and the AUC-insulin significantly decreased by the end of the trial in a similar fashion in both groups, while the AUC-PRL significantly increased at the end of the trial in both groups. At no time were significant correlations between AUC-PRL and AUC-insulin or the indexes HOMA-IR, QUICKI or fasting glucose-insulin ratio observed. The present results suggests that either pioglitazone or metformin administration was associated with a clear improvement in the endogenous hypothalamic DA tone, simultaneously with an amelioration of the insulin resistance status in these obese women with PCOS.

Authors+Show Affiliations

Department of Endocrinology, Instituto Nacional de Perinatología, México City, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15642799

Citation

Ortega-González, C, et al. "Insulin Sensitizing Drugs Increase the Endogenous Dopaminergic Tone in Obese Insulin-resistant Women With Polycystic Ovary Syndrome." The Journal of Endocrinology, vol. 184, no. 1, 2005, pp. 233-9.
Ortega-González C, Cardoza L, Coutiño B, et al. Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. J Endocrinol. 2005;184(1):233-9.
Ortega-González, C., Cardoza, L., Coutiño, B., Hidalgo, R., Arteaga-Troncoso, G., & Parra, A. (2005). Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. The Journal of Endocrinology, 184(1), 233-9.
Ortega-González C, et al. Insulin Sensitizing Drugs Increase the Endogenous Dopaminergic Tone in Obese Insulin-resistant Women With Polycystic Ovary Syndrome. J Endocrinol. 2005;184(1):233-9. PubMed PMID: 15642799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome. AU - Ortega-González,C, AU - Cardoza,L, AU - Coutiño,B, AU - Hidalgo,R, AU - Arteaga-Troncoso,G, AU - Parra,A, PY - 2005/1/12/pubmed PY - 2005/2/26/medline PY - 2005/1/12/entrez SP - 233 EP - 9 JF - The Journal of endocrinology JO - J Endocrinol VL - 184 IS - 1 N2 - To investigate whether the long-term administration of metformin or pioglitazone to women with polycystic ovary syndrome (PCOS) could induce changes in their hypothalamic dopaminergic (DA) tone and to analyze whether these changes correlated with modifications in insulin resistance, we originally studied 57 obese hyperinsulinemic, non-diabetic, insulin resistant women with PCOS, but only 34 completed the study. They were randomly divided into two groups: group one (n=17) received pioglitazone (30 mg/day) and group 2 (n=17) received metformin (850 mg, three times a day) over 24 weeks. All women were identically studied before (basal) and 6 months after (T6) drug administration, including clinical evaluations, a 2 h oral glucose tolerance test (75 g) (OGTT) for glucose and insulin measurements, followed a week later by a 2 h intravenous metoclopramide test (10 mg bolus) for prolactin (PRL) determinations. The areas under the insulin (AUC-insulin) and PRL (AUC-PRL) curves were calculated, along with the index of insulin resistance (HOMA-IR) and the indexes of insulin sensitivity (QUICKI and fasting glucose-insulin ratio). At baseline, women in both groups were of similar age, body weight, body mass index (BMI) and Ferriman-Gallwey hirsutism score (F-G score). At completion of the study, body weight and BMI remained unchanged but the F-G score significantly decreased. Fasting serum insulin concentrations and the AUC-insulin significantly decreased by the end of the trial in a similar fashion in both groups, while the AUC-PRL significantly increased at the end of the trial in both groups. At no time were significant correlations between AUC-PRL and AUC-insulin or the indexes HOMA-IR, QUICKI or fasting glucose-insulin ratio observed. The present results suggests that either pioglitazone or metformin administration was associated with a clear improvement in the endogenous hypothalamic DA tone, simultaneously with an amelioration of the insulin resistance status in these obese women with PCOS. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/15642799/Insulin_sensitizing_drugs_increase_the_endogenous_dopaminergic_tone_in_obese_insulin_resistant_women_with_polycystic_ovary_syndrome_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.1.05844 DB - PRIME DP - Unbound Medicine ER -