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A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study.
Arch Neurol. 2005 Jan; 62(1):55-60.AN

Abstract

BACKGROUND

The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome.

OBJECTIVE

To compare the natural history of weight change from mid to late life in men with and without dementia in late life.

DESIGN AND SETTING

The Honolulu-Asia Aging Study, a 32-year, prospective, population-based study of Japanese American men who had been weighed on 6 occasions between 1965 and 1999 and who had been screened for dementia 3 times between 1991 and 1999.

PARTICIPANTS

Of 1890 men (aged 77-98 years), 112 with incident dementia were compared with 1778 without dementia at the sixth examination (1997-1999).

MAIN OUTCOME MEASURE

Weight change up to and including the sixth examination was treated as the dependent variable and estimated using a repeated measures analysis.

RESULTS

Groups with and without dementia did not differ with respect to baseline weight or change in weight from mid to late life (first 26 years' follow-up). In the late-life examinations (final 6 years), mean age- and education-adjusted weight loss was -0.22 kg/y (95% confidence intervals, -0.26 to -0.18) in participants without dementia. Men with incident dementia at the same examination had an additional yearly weight loss of -0.36 kg (95% confidence interval, -0.53 to -0.19). This was not changed substantially with adjustment for risk factors for vascular disease or functional impairment and was significant for both Alzheimer disease and vascular dementia subtypes.

CONCLUSIONS

Dementia-associated weight loss begins before the onset of the clinical syndrome and accelerates by the time of diagnosis. The potential impact on prognosis should be considered in the case of elderly persons at risk for dementia.

Authors+Show Affiliations

Institute of Psychiatry, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15642850

Citation

Stewart, Robert, et al. "A 32-year Prospective Study of Change in Body Weight and Incident Dementia: the Honolulu-Asia Aging Study." Archives of Neurology, vol. 62, no. 1, 2005, pp. 55-60.
Stewart R, Masaki K, Xue QL, et al. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol. 2005;62(1):55-60.
Stewart, R., Masaki, K., Xue, Q. L., Peila, R., Petrovitch, H., White, L. R., & Launer, L. J. (2005). A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Archives of Neurology, 62(1), 55-60.
Stewart R, et al. A 32-year Prospective Study of Change in Body Weight and Incident Dementia: the Honolulu-Asia Aging Study. Arch Neurol. 2005;62(1):55-60. PubMed PMID: 15642850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. AU - Stewart,Robert, AU - Masaki,Kamal, AU - Xue,Qian-Li, AU - Peila,Rita, AU - Petrovitch,Helen, AU - White,Lon R, AU - Launer,Lenore J, PY - 2005/1/12/pubmed PY - 2005/3/8/medline PY - 2005/1/12/entrez SP - 55 EP - 60 JF - Archives of neurology JO - Arch. Neurol. VL - 62 IS - 1 N2 - BACKGROUND: The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome. OBJECTIVE: To compare the natural history of weight change from mid to late life in men with and without dementia in late life. DESIGN AND SETTING: The Honolulu-Asia Aging Study, a 32-year, prospective, population-based study of Japanese American men who had been weighed on 6 occasions between 1965 and 1999 and who had been screened for dementia 3 times between 1991 and 1999. PARTICIPANTS: Of 1890 men (aged 77-98 years), 112 with incident dementia were compared with 1778 without dementia at the sixth examination (1997-1999). MAIN OUTCOME MEASURE: Weight change up to and including the sixth examination was treated as the dependent variable and estimated using a repeated measures analysis. RESULTS: Groups with and without dementia did not differ with respect to baseline weight or change in weight from mid to late life (first 26 years' follow-up). In the late-life examinations (final 6 years), mean age- and education-adjusted weight loss was -0.22 kg/y (95% confidence intervals, -0.26 to -0.18) in participants without dementia. Men with incident dementia at the same examination had an additional yearly weight loss of -0.36 kg (95% confidence interval, -0.53 to -0.19). This was not changed substantially with adjustment for risk factors for vascular disease or functional impairment and was significant for both Alzheimer disease and vascular dementia subtypes. CONCLUSIONS: Dementia-associated weight loss begins before the onset of the clinical syndrome and accelerates by the time of diagnosis. The potential impact on prognosis should be considered in the case of elderly persons at risk for dementia. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15642850/A_32_year_prospective_study_of_change_in_body_weight_and_incident_dementia:_the_Honolulu_Asia_Aging_Study_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.62.1.55 DB - PRIME DP - Unbound Medicine ER -