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[Optimizing ovarian stimulation for IVF using GnRH antagonists].
J Gynecol Obstet Biol Reprod (Paris). 2004 Oct; 33(6 Pt 2):3S42-5.JG

Abstract

ART teams have failed to predict that pregnancy rates in GnRH antagonist regimens will be lower compared to the agonist regimens. No evidence appears to exist for an adverse effect of GnRH antagonists on oocyte/embryo quality. Abnormal development of endometrium at OPU is present in all cycles stimulated with GnRH antagonists and it is also encountered in all stimulation schemes using gonadotropins. Endometrium advancement is negatively associated with the probability of pregnancy. Endometrium histology at oocyte retrieval is positively associated with LH levels at initiation of stimulation and the duration of rec FSH stimulation prior to antagonist initiation. The presence of elevated serum progesterone on day two of the cycle is associated with a higher exposure to progesterone and a decreased probability of pregnancy. The higher the LH levels on day 8 of stimulation, the lower the probability of pregnancy. Low E2 levels on the day of hCG administration are not associated with a decreased probability of pregnancy. Ovarian stimulation for IVF alters steroid receptor kinetics in the follicular phase. Prolongation of follicular phase is associated with a decreased probability of pregnancy. Prolongation of follicular phase results in secretory changes of endometrium at OPU.

Authors+Show Affiliations

Center for Reproductive Medicine, Dutch Speaking Brussels Free University, Belgique.

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

15643688

Citation

Kolibianakis, E M.. "[Optimizing Ovarian Stimulation for IVF Using GnRH Antagonists]." Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction, vol. 33, no. 6 Pt 2, 2004, pp. 3S42-5.
Kolibianakis EM. [Optimizing ovarian stimulation for IVF using GnRH antagonists]. J Gynecol Obstet Biol Reprod (Paris). 2004;33(6 Pt 2):3S42-5.
Kolibianakis, E. M. (2004). [Optimizing ovarian stimulation for IVF using GnRH antagonists]. Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction, 33(6 Pt 2), 3S42-5.
Kolibianakis EM. [Optimizing Ovarian Stimulation for IVF Using GnRH Antagonists]. J Gynecol Obstet Biol Reprod (Paris). 2004;33(6 Pt 2):3S42-5. PubMed PMID: 15643688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Optimizing ovarian stimulation for IVF using GnRH antagonists]. A1 - Kolibianakis,E M, PY - 2005/1/12/pubmed PY - 2005/2/23/medline PY - 2005/1/12/entrez SP - 3S42 EP - 5 JF - Journal de gynecologie, obstetrique et biologie de la reproduction JO - J Gynecol Obstet Biol Reprod (Paris) VL - 33 IS - 6 Pt 2 N2 - ART teams have failed to predict that pregnancy rates in GnRH antagonist regimens will be lower compared to the agonist regimens. No evidence appears to exist for an adverse effect of GnRH antagonists on oocyte/embryo quality. Abnormal development of endometrium at OPU is present in all cycles stimulated with GnRH antagonists and it is also encountered in all stimulation schemes using gonadotropins. Endometrium advancement is negatively associated with the probability of pregnancy. Endometrium histology at oocyte retrieval is positively associated with LH levels at initiation of stimulation and the duration of rec FSH stimulation prior to antagonist initiation. The presence of elevated serum progesterone on day two of the cycle is associated with a higher exposure to progesterone and a decreased probability of pregnancy. The higher the LH levels on day 8 of stimulation, the lower the probability of pregnancy. Low E2 levels on the day of hCG administration are not associated with a decreased probability of pregnancy. Ovarian stimulation for IVF alters steroid receptor kinetics in the follicular phase. Prolongation of follicular phase is associated with a decreased probability of pregnancy. Prolongation of follicular phase results in secretory changes of endometrium at OPU. SN - 0368-2315 UR - https://www.unboundmedicine.com/medline/citation/15643688/[Optimizing_ovarian_stimulation_for_IVF_using_GnRH_antagonists]_ DB - PRIME DP - Unbound Medicine ER -