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The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients.
Acta Neurol Scand. 2005 Feb; 111(2):89-94.AN

Abstract

OBJECTIVES

Contradictory possible cardiovascular side effects of selegiline have been reported. Therefore, we studied the effect of acute administration of selegiline with levodopa (LD) compared with LD alone, on blood pressure, pulse and norepinephrine (NE) plasma levels, during an orthostatic test on chronically treated Parkinson's disease patients (PDpts) and controls.

MATERIALS AND METHODS

Twelve PDpts treated with LD (group D), 12 PDpts treated with selegiline and LD (group S) and eight volunteers (CTRL) underwent the orthostatic test. Patients repeated the test twice, before and after acute loading with 125 mg LD (group D) and 125 mg LD +5 mg selegiline (group S).

RESULTS

Group S showed more episodes of postural hypotension (n = 10; two symptomatic) than group D (n = 4) and CTRL (n = 2), however not statistically significant. Plasma NE also rose significantly higher (P < 0.001) in group S.

CONCLUSION

PD patients treated with selegiline showed more orthostatism and higher plasma NE after submission to the orthostatic test. These findings may be relevant to explain its deleterious effect.

Authors+Show Affiliations

Stryjer R
Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel.
Klein C
No affiliation info available
Treves TA
No affiliation info available
Rabey JM
No affiliation info available

MeSH

AgedAntiparkinson AgentsBlood PressureDose-Response Relationship, DrugDrug Therapy, CombinationFemaleHumansLevodopaMaleMiddle AgedNorepinephrineParkinson DiseasePulseRestSelegilineSupine Position

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

15644067

Clinical Trial Links

The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease

Citation

Stryjer, R, et al. "The Effects of Acute Loading With Levodopa and Levodopa With Selegiline On Blood Pressure and Plasma Norepinephrine Levels in Chronic Parkinson's Disease Patients." Acta Neurologica Scandinavica, vol. 111, no. 2, 2005, pp. 89-94.
Stryjer R, Klein C, Treves TA, et al. The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients. Acta Neurol Scand. 2005;111(2):89-94.
Stryjer, R., Klein, C., Treves, T. A., & Rabey, J. M. (2005). The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients. Acta Neurologica Scandinavica, 111(2), 89-94.
Stryjer R, et al. The Effects of Acute Loading With Levodopa and Levodopa With Selegiline On Blood Pressure and Plasma Norepinephrine Levels in Chronic Parkinson's Disease Patients. Acta Neurol Scand. 2005;111(2):89-94. PubMed PMID: 15644067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients. AU - Stryjer,R, AU - Klein,C, AU - Treves,T A, AU - Rabey,J M, PY - 2005/1/13/pubmed PY - 2005/3/30/medline PY - 2005/1/13/entrez SP - 89 EP - 94 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 111 IS - 2 N2 - OBJECTIVES: Contradictory possible cardiovascular side effects of selegiline have been reported. Therefore, we studied the effect of acute administration of selegiline with levodopa (LD) compared with LD alone, on blood pressure, pulse and norepinephrine (NE) plasma levels, during an orthostatic test on chronically treated Parkinson's disease patients (PDpts) and controls. MATERIALS AND METHODS: Twelve PDpts treated with LD (group D), 12 PDpts treated with selegiline and LD (group S) and eight volunteers (CTRL) underwent the orthostatic test. Patients repeated the test twice, before and after acute loading with 125 mg LD (group D) and 125 mg LD +5 mg selegiline (group S). RESULTS: Group S showed more episodes of postural hypotension (n = 10; two symptomatic) than group D (n = 4) and CTRL (n = 2), however not statistically significant. Plasma NE also rose significantly higher (P < 0.001) in group S. CONCLUSION: PD patients treated with selegiline showed more orthostatism and higher plasma NE after submission to the orthostatic test. These findings may be relevant to explain its deleterious effect. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/15644067/The_effects_of_acute_loading_with_levodopa_and_levodopa_with_selegiline_on_blood_pressure_and_plasma_norepinephrine_levels_in_chronic_Parkinson's_disease_patients_ DB - PRIME DP - Unbound Medicine ER -