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Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs.
Artif Organs. 2005 Jan; 29(1):83-7.AO

Abstract

An artificial endocrine pancreas is a mechanical device that frequently measures blood glucose and adjusts the rate of insulin infusion to maintain normoglycemia. In this study, we evaluated the effect of pancreatic polypeptide (PP) on insulin requirements after total pancreatectomy. However, other endocrine hormones are needed not only to facilitate the effect of insulin, but also to regulate insulin functions in vivo. In this study, the effect of PP infusion on insulin requirements after total pancreatectomy in dogs is examined. After total pancreatectomy, five dogs were supported by artificial endocrine pancreas model STG-22 for 72 h. In a second group of five dogs, both insulin and PP were infused. Mean blood glucose levels and insulin requirements were compared between the two groups. There was no difference in mean plasma glucose levels between the two groups. In all 10 dogs, the mean blood glucose level for 72 h was 110 +/- 4 mg/dL and was tightly controlled between 65 and 190 mg/dL. However, the insulin requirement for the first and second postoperative days in the group treated with PP was significantly less than that of the control group (90.0 +/- 20.8 mU/kg vs. 445.0 +/- 151.9 mU/kg; P < 0.05, and 562.7 +/- 126.5 mU/kg vs. 1007.7 +/- 144.9 mU/kg; P < 0.05, respectively). We conclude that infusion of PP reduces the insulin requirement for the initial 48 h in pancreatectomized dogs treated with an artificial endocrine pancreas.

Authors+Show Affiliations

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15644089

Citation

Kono, Tetsuya, et al. "Pancreatic Polypeptide Administration Reduces Insulin Requirements of Artificial Pancreas in Pancreatectomized Dogs." Artificial Organs, vol. 29, no. 1, 2005, pp. 83-7.
Kono T, Hanazaki K, Yazawa K, et al. Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs. Artif Organs. 2005;29(1):83-7.
Kono, T., Hanazaki, K., Yazawa, K., Ashizawa, S., Fisher, W. E., Wang, X. P., Nosé, Y., & Brunicardi, F. C. (2005). Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs. Artificial Organs, 29(1), 83-7.
Kono T, et al. Pancreatic Polypeptide Administration Reduces Insulin Requirements of Artificial Pancreas in Pancreatectomized Dogs. Artif Organs. 2005;29(1):83-7. PubMed PMID: 15644089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic polypeptide administration reduces insulin requirements of artificial pancreas in pancreatectomized dogs. AU - Kono,Tetsuya, AU - Hanazaki,Kazuhiro, AU - Yazawa,Kazuyuki, AU - Ashizawa,Satoshi, AU - Fisher,William E, AU - Wang,Xiao-Ping, AU - Nosé,Yukihiko, AU - Brunicardi,F Charles, PY - 2005/1/13/pubmed PY - 2005/7/13/medline PY - 2005/1/13/entrez SP - 83 EP - 7 JF - Artificial organs JO - Artif Organs VL - 29 IS - 1 N2 - An artificial endocrine pancreas is a mechanical device that frequently measures blood glucose and adjusts the rate of insulin infusion to maintain normoglycemia. In this study, we evaluated the effect of pancreatic polypeptide (PP) on insulin requirements after total pancreatectomy. However, other endocrine hormones are needed not only to facilitate the effect of insulin, but also to regulate insulin functions in vivo. In this study, the effect of PP infusion on insulin requirements after total pancreatectomy in dogs is examined. After total pancreatectomy, five dogs were supported by artificial endocrine pancreas model STG-22 for 72 h. In a second group of five dogs, both insulin and PP were infused. Mean blood glucose levels and insulin requirements were compared between the two groups. There was no difference in mean plasma glucose levels between the two groups. In all 10 dogs, the mean blood glucose level for 72 h was 110 +/- 4 mg/dL and was tightly controlled between 65 and 190 mg/dL. However, the insulin requirement for the first and second postoperative days in the group treated with PP was significantly less than that of the control group (90.0 +/- 20.8 mU/kg vs. 445.0 +/- 151.9 mU/kg; P < 0.05, and 562.7 +/- 126.5 mU/kg vs. 1007.7 +/- 144.9 mU/kg; P < 0.05, respectively). We conclude that infusion of PP reduces the insulin requirement for the initial 48 h in pancreatectomized dogs treated with an artificial endocrine pancreas. SN - 0160-564X UR - https://www.unboundmedicine.com/medline/citation/15644089/Pancreatic_polypeptide_administration_reduces_insulin_requirements_of_artificial_pancreas_in_pancreatectomized_dogs_ L2 - https://doi.org/10.1111/j.1525-1594.2004.29008.x DB - PRIME DP - Unbound Medicine ER -