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Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders.
Age Ageing. 2005 Mar; 34(2):136-41.AA

Abstract

BACKGROUND

Subjects with dementia are at risk for protein-energy malnutrition.

OBJECTIVE

To study the nutritional status, the short-term effects of adapted nutritional routines and the long-term mortality in subjects admitted for evaluation of cognitive dysfunction.

DESIGN

prospective observational study.

SETTING

University Hospital.

SUBJECTS

A total of 231 patients (80 +/- 7 years, 65% women).

METHODS

Body mass index (BMI, kg/m2), serum concentrations of albumin, ferritin, vitamin B12, folic acid and haemoglobin as well as Mini-Mental State Examination (MMSE, 0-30 p) results and co-morbidity were recorded at hospital admittance and before discharge. Seven years later, mortality was registered.

RESULTS

Mean BMI was in the normal range (23.3 +/- 4) as were the biochemical indices, and they did not vary among patients with Alzheimer's disease (AD), vascular dementia (VaD), mild cognitive impairment, mixed dementia and other diagnoses. A BMI of <23 was found in 108 (52%) subjects. Weight and MMSE score correlated weakly (r = 0.18, P < 0.01) at inclusion. During a median hospital stay of 3 weeks, an average weight gain of 0.5 +/- 1.8 kg (P < 0.001) and an increase in MMSE score of 0.9 +/- 3 (P < 0.001) was observed. However, these changes did not correlate. A BMI of <23 was associated with an increased risk for 7-year mortality (OR 3, 95% CI = 1.3-6.7), which was independent of age, male gender, dementia diagnosis and co-morbidity.

CONCLUSIONS

Nutritional status did not vary in patients with various dementia diagnoses. A BMI of <23 was related to reduced 7-year survival, but this result was independent of co-morbidity, male gender and age.

Authors+Show Affiliations

Karolinska Institutet, Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden. gerd.faxen-irving@karolinska.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15644407

Citation

Faxén-Irving, Gerd, et al. "Nutritional and Cognitive Relationships and Long-term Mortality in Patients With Various Dementia Disorders." Age and Ageing, vol. 34, no. 2, 2005, pp. 136-41.
Faxén-Irving G, Basun H, Cederholm T. Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders. Age Ageing. 2005;34(2):136-41.
Faxén-Irving, G., Basun, H., & Cederholm, T. (2005). Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders. Age and Ageing, 34(2), 136-41.
Faxén-Irving G, Basun H, Cederholm T. Nutritional and Cognitive Relationships and Long-term Mortality in Patients With Various Dementia Disorders. Age Ageing. 2005;34(2):136-41. PubMed PMID: 15644407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders. AU - Faxén-Irving,Gerd, AU - Basun,Hans, AU - Cederholm,Tommy, Y1 - 2005/01/11/ PY - 2005/1/13/pubmed PY - 2005/8/24/medline PY - 2005/1/13/entrez SP - 136 EP - 41 JF - Age and ageing JO - Age Ageing VL - 34 IS - 2 N2 - BACKGROUND: Subjects with dementia are at risk for protein-energy malnutrition. OBJECTIVE: To study the nutritional status, the short-term effects of adapted nutritional routines and the long-term mortality in subjects admitted for evaluation of cognitive dysfunction. DESIGN: prospective observational study. SETTING: University Hospital. SUBJECTS: A total of 231 patients (80 +/- 7 years, 65% women). METHODS: Body mass index (BMI, kg/m2), serum concentrations of albumin, ferritin, vitamin B12, folic acid and haemoglobin as well as Mini-Mental State Examination (MMSE, 0-30 p) results and co-morbidity were recorded at hospital admittance and before discharge. Seven years later, mortality was registered. RESULTS: Mean BMI was in the normal range (23.3 +/- 4) as were the biochemical indices, and they did not vary among patients with Alzheimer's disease (AD), vascular dementia (VaD), mild cognitive impairment, mixed dementia and other diagnoses. A BMI of <23 was found in 108 (52%) subjects. Weight and MMSE score correlated weakly (r = 0.18, P < 0.01) at inclusion. During a median hospital stay of 3 weeks, an average weight gain of 0.5 +/- 1.8 kg (P < 0.001) and an increase in MMSE score of 0.9 +/- 3 (P < 0.001) was observed. However, these changes did not correlate. A BMI of <23 was associated with an increased risk for 7-year mortality (OR 3, 95% CI = 1.3-6.7), which was independent of age, male gender, dementia diagnosis and co-morbidity. CONCLUSIONS: Nutritional status did not vary in patients with various dementia diagnoses. A BMI of <23 was related to reduced 7-year survival, but this result was independent of co-morbidity, male gender and age. SN - 0002-0729 UR - https://www.unboundmedicine.com/medline/citation/15644407/Nutritional_and_cognitive_relationships_and_long_term_mortality_in_patients_with_various_dementia_disorders_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afi023 DB - PRIME DP - Unbound Medicine ER -