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Sulfonamide cross-reactivity: fact or fiction?
Ann Pharmacother. 2005 Feb; 39(2):290-301.AP

Abstract

OBJECTIVE

To provide a critical and comprehensive review of the literature, specifically case reports and observational studies used to support the concept of cross-reactivity between sulfonylarylamines and non-sulfonylarylamines.

DATA SOURCES

A list of medications was formulated from several different review articles. A MEDLINE/PubMed search was conducted (1966-March 2004) using the individual medications and the MeSH terms of drug hypersensitivity/etiology, sulfonamides/adverse effects, and/or cross-reaction.

STUDY SELECTION AND DATA EXTRACTION

A critical review of the methodology and conclusions for each article found in the search was conducted. The manufacturer's package insert (MPI) for each drug was examined for a statement concerning possible cross-reactivity in patients with a sulfonamide allergy. If indicated, the manufacturers were contacted to obtain any clinical data supporting the statement.

DATA SYNTHESIS

A total of 33 medications were identified. Seventeen (51.5%) of the MPIs contained statements of varying degrees concerning use in patients with a "sulfonamide" allergy; 21 case series, case reports, and other articles were found.

CONCLUSIONS

After a thorough critique of the literature, it appears that the dogma of sulfonylarylamine cross-reactivity with non-sulfonylarylamines is not supported by the data. While many of the case reports on the surface support the concept of cross-reactivity, on closer examination the level of evidence in many of the cases does not conclusively support either a connection or an association between the observed cause and effect.

Authors+Show Affiliations

Adult Internal Medicine Pharmacy Resident, Department of Pharmacy Services, Virginia Commonwealth University Medical Center-Medical College of Virginia (MCV) Campus, Richmond, VA 23298-0042, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15644481

Citation

Johnson, Kelly K., et al. "Sulfonamide Cross-reactivity: Fact or Fiction?" The Annals of Pharmacotherapy, vol. 39, no. 2, 2005, pp. 290-301.
Johnson KK, Green DL, Rife JP, et al. Sulfonamide cross-reactivity: fact or fiction? Ann Pharmacother. 2005;39(2):290-301.
Johnson, K. K., Green, D. L., Rife, J. P., & Limon, L. (2005). Sulfonamide cross-reactivity: fact or fiction? The Annals of Pharmacotherapy, 39(2), 290-301.
Johnson KK, et al. Sulfonamide Cross-reactivity: Fact or Fiction. Ann Pharmacother. 2005;39(2):290-301. PubMed PMID: 15644481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfonamide cross-reactivity: fact or fiction? AU - Johnson,Kelly K, AU - Green,David L, AU - Rife,Jason P, AU - Limon,Lynn, Y1 - 2005/01/11/ PY - 2005/1/13/pubmed PY - 2005/6/9/medline PY - 2005/1/13/entrez SP - 290 EP - 301 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 39 IS - 2 N2 - OBJECTIVE: To provide a critical and comprehensive review of the literature, specifically case reports and observational studies used to support the concept of cross-reactivity between sulfonylarylamines and non-sulfonylarylamines. DATA SOURCES: A list of medications was formulated from several different review articles. A MEDLINE/PubMed search was conducted (1966-March 2004) using the individual medications and the MeSH terms of drug hypersensitivity/etiology, sulfonamides/adverse effects, and/or cross-reaction. STUDY SELECTION AND DATA EXTRACTION: A critical review of the methodology and conclusions for each article found in the search was conducted. The manufacturer's package insert (MPI) for each drug was examined for a statement concerning possible cross-reactivity in patients with a sulfonamide allergy. If indicated, the manufacturers were contacted to obtain any clinical data supporting the statement. DATA SYNTHESIS: A total of 33 medications were identified. Seventeen (51.5%) of the MPIs contained statements of varying degrees concerning use in patients with a "sulfonamide" allergy; 21 case series, case reports, and other articles were found. CONCLUSIONS: After a thorough critique of the literature, it appears that the dogma of sulfonylarylamine cross-reactivity with non-sulfonylarylamines is not supported by the data. While many of the case reports on the surface support the concept of cross-reactivity, on closer examination the level of evidence in many of the cases does not conclusively support either a connection or an association between the observed cause and effect. SN - 1060-0280 UR - https://www.unboundmedicine.com/medline/citation/15644481/Sulfonamide_cross_reactivity:_fact_or_fiction L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1E350?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -