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TRPV1b, a functional human vanilloid receptor splice variant.
Mol Pharmacol. 2005 Apr; 67(4):1119-27.MP

Abstract

Transient receptor potential (TRP) genes encode a family of related ion-channel subunits. This family consists of cation-selective, calcium-permeable channels that include a group of vanilloid receptor channels (TRPV) implicated in pain and inflammation. These channels are activated by diverse stimuli, including capsaicin, lipids, membrane deformation, heat, and protons. Six members of the TRPV family have been identified that differ predominantly in their activation properties. However, in neurons, TRPV channels do not account for the observed diversity of responses to activators. By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons. Channels with similar activation properties were found in trigeminal ganglion neurons, suggesting that TRPV1b receptors are expressed in these cells and contribute to thermal nociception.

Authors+Show Affiliations

Box 3209, Duke University Medical Center, Durham, NC 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15644492

Citation

Lu, Gang, et al. "TRPV1b, a Functional Human Vanilloid Receptor Splice Variant." Molecular Pharmacology, vol. 67, no. 4, 2005, pp. 1119-27.
Lu G, Henderson D, Liu L, et al. TRPV1b, a functional human vanilloid receptor splice variant. Mol Pharmacol. 2005;67(4):1119-27.
Lu, G., Henderson, D., Liu, L., Reinhart, P. H., & Simon, S. A. (2005). TRPV1b, a functional human vanilloid receptor splice variant. Molecular Pharmacology, 67(4), 1119-27.
Lu G, et al. TRPV1b, a Functional Human Vanilloid Receptor Splice Variant. Mol Pharmacol. 2005;67(4):1119-27. PubMed PMID: 15644492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRPV1b, a functional human vanilloid receptor splice variant. AU - Lu,Gang, AU - Henderson,Dorian, AU - Liu,Lieju, AU - Reinhart,Peter H, AU - Simon,Sidney A, Y1 - 2005/01/11/ PY - 2005/1/13/pubmed PY - 2005/4/21/medline PY - 2005/1/13/entrez SP - 1119 EP - 27 JF - Molecular pharmacology JO - Mol. Pharmacol. VL - 67 IS - 4 N2 - Transient receptor potential (TRP) genes encode a family of related ion-channel subunits. This family consists of cation-selective, calcium-permeable channels that include a group of vanilloid receptor channels (TRPV) implicated in pain and inflammation. These channels are activated by diverse stimuli, including capsaicin, lipids, membrane deformation, heat, and protons. Six members of the TRPV family have been identified that differ predominantly in their activation properties. However, in neurons, TRPV channels do not account for the observed diversity of responses to activators. By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons. Channels with similar activation properties were found in trigeminal ganglion neurons, suggesting that TRPV1b receptors are expressed in these cells and contribute to thermal nociception. SN - 0026-895X UR - https://www.unboundmedicine.com/medline/citation/15644492/TRPV1b_a_functional_human_vanilloid_receptor_splice_variant_ L2 - http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=15644492 DB - PRIME DP - Unbound Medicine ER -