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Meat consumption and risk of colorectal cancer.

Abstract

CONTEXT

Consumption of red and processed meat has been associated with colorectal cancer in many but not all epidemiological studies; few studies have examined risk in relation to long-term meat intake or the association of meat with rectal cancer.

OBJECTIVE

To examine the relationship between recent and long-term meat consumption and the risk of incident colon and rectal cancer.

DESIGN, SETTING, AND PARTICIPANTS

A cohort of 148 610 adults aged 50 to 74 years (median, 63 years), residing in 21 states with population-based cancer registries, who provided information on meat consumption in 1982 and again in 1992/1993 when enrolled in the Cancer Prevention Study II (CPS II) Nutrition Cohort. Follow-up from time of enrollment in 1992/1993 through August 31, 2001, identified 1667 incident colorectal cancers. Participants contributed person-years at risk until death or a diagnosis of colon or rectal cancer.

MAIN OUTCOME MEASURE

Incidence rate ratio (RR) of colon and rectal cancer.

RESULTS

High intake of red and processed meat reported in 1992/1993 was associated with higher risk of colon cancer after adjusting for age and energy intake but not after further adjustment for body mass index, cigarette smoking, and other covariates. When long-term consumption was considered, persons in the highest tertile of consumption in both 1982 and 1992/1993 had higher risk of distal colon cancer associated with processed meat (RR, 1.50; 95% confidence interval [CI], 1.04-2.17), and ratio of red meat to poultry and fish (RR, 1.53; 95% CI, 1.08-2.18) relative to those persons in the lowest tertile at both time points. Long-term consumption of poultry and fish was inversely associated with risk of both proximal and distal colon cancer. High consumption of red meat reported in 1992/1993 was associated with higher risk of rectal cancer (RR, 1.71; 95% CI, 1.15-2.52; P = .007 for trend), as was high consumption reported in both 1982 and 1992/1993 (RR, 1.43; 95% CI, 1.00-2.05).

CONCLUSIONS

Our results demonstrate the potential value of examining long-term meat consumption in assessing cancer risk and strengthen the evidence that prolonged high consumption of red and processed meat may increase the risk of cancer in the distal portion of the large intestine.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Ga 30329-4251, USA.

    , , , , , , ,

    Source

    JAMA 293:2 2005 Jan 12 pg 172-82

    MeSH

    Aged
    Body Mass Index
    Cohort Studies
    Colonic Neoplasms
    Diet
    Female
    Humans
    Incidence
    Male
    Meat
    Middle Aged
    Multivariate Analysis
    Proportional Hazards Models
    Rectal Neoplasms
    Registries
    Risk Factors
    Smoking
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15644544

    Citation

    Chao, Ann, et al. "Meat Consumption and Risk of Colorectal Cancer." JAMA, vol. 293, no. 2, 2005, pp. 172-82.
    Chao A, Thun MJ, Connell CJ, et al. Meat consumption and risk of colorectal cancer. JAMA. 2005;293(2):172-82.
    Chao, A., Thun, M. J., Connell, C. J., McCullough, M. L., Jacobs, E. J., Flanders, W. D., ... Calle, E. E. (2005). Meat consumption and risk of colorectal cancer. JAMA, 293(2), pp. 172-82.
    Chao A, et al. Meat Consumption and Risk of Colorectal Cancer. JAMA. 2005 Jan 12;293(2):172-82. PubMed PMID: 15644544.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Meat consumption and risk of colorectal cancer. AU - Chao,Ann, AU - Thun,Michael J, AU - Connell,Cari J, AU - McCullough,Marjorie L, AU - Jacobs,Eric J, AU - Flanders,W Dana, AU - Rodriguez,Carmen, AU - Sinha,Rashmi, AU - Calle,Eugenia E, PY - 2005/1/13/pubmed PY - 2005/2/3/medline PY - 2005/1/13/entrez SP - 172 EP - 82 JF - JAMA JO - JAMA VL - 293 IS - 2 N2 - CONTEXT: Consumption of red and processed meat has been associated with colorectal cancer in many but not all epidemiological studies; few studies have examined risk in relation to long-term meat intake or the association of meat with rectal cancer. OBJECTIVE: To examine the relationship between recent and long-term meat consumption and the risk of incident colon and rectal cancer. DESIGN, SETTING, AND PARTICIPANTS: A cohort of 148 610 adults aged 50 to 74 years (median, 63 years), residing in 21 states with population-based cancer registries, who provided information on meat consumption in 1982 and again in 1992/1993 when enrolled in the Cancer Prevention Study II (CPS II) Nutrition Cohort. Follow-up from time of enrollment in 1992/1993 through August 31, 2001, identified 1667 incident colorectal cancers. Participants contributed person-years at risk until death or a diagnosis of colon or rectal cancer. MAIN OUTCOME MEASURE: Incidence rate ratio (RR) of colon and rectal cancer. RESULTS: High intake of red and processed meat reported in 1992/1993 was associated with higher risk of colon cancer after adjusting for age and energy intake but not after further adjustment for body mass index, cigarette smoking, and other covariates. When long-term consumption was considered, persons in the highest tertile of consumption in both 1982 and 1992/1993 had higher risk of distal colon cancer associated with processed meat (RR, 1.50; 95% confidence interval [CI], 1.04-2.17), and ratio of red meat to poultry and fish (RR, 1.53; 95% CI, 1.08-2.18) relative to those persons in the lowest tertile at both time points. Long-term consumption of poultry and fish was inversely associated with risk of both proximal and distal colon cancer. High consumption of red meat reported in 1992/1993 was associated with higher risk of rectal cancer (RR, 1.71; 95% CI, 1.15-2.52; P = .007 for trend), as was high consumption reported in both 1982 and 1992/1993 (RR, 1.43; 95% CI, 1.00-2.05). CONCLUSIONS: Our results demonstrate the potential value of examining long-term meat consumption in assessing cancer risk and strengthen the evidence that prolonged high consumption of red and processed meat may increase the risk of cancer in the distal portion of the large intestine. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/15644544/full_citation L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.293.2.172 DB - PRIME DP - Unbound Medicine ER -