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Consumption of vegetables and fruits and risk of breast cancer.

Abstract

CONTEXT

The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption.

OBJECTIVE

To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer.

DESIGN, SETTING, AND PARTICIPANTS

Prospective study of 285,526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002.

MAIN OUTCOME MEASURES

Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors.

RESULTS

During 1,486,402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI , 0.94-1.25) for total fruit, and 1.05 (95% CI , 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either.

CONCLUSION

Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    JAMA 293:2 2005 Jan 12 pg 183-93

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Diet
    Europe
    Female
    Fruit
    Humans
    Incidence
    Life Style
    Middle Aged
    Prospective Studies
    Risk
    Risk Factors
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15644545

    Citation

    van Gils, Carla H., et al. "Consumption of Vegetables and Fruits and Risk of Breast Cancer." JAMA, vol. 293, no. 2, 2005, pp. 183-93.
    van Gils CH, Peeters PH, Bueno-de-Mesquita HB, et al. Consumption of vegetables and fruits and risk of breast cancer. JAMA. 2005;293(2):183-93.
    van Gils, C. H., Peeters, P. H., Bueno-de-Mesquita, H. B., Boshuizen, H. C., Lahmann, P. H., Clavel-Chapelon, F., ... Riboli, E. (2005). Consumption of vegetables and fruits and risk of breast cancer. JAMA, 293(2), pp. 183-93.
    van Gils CH, et al. Consumption of Vegetables and Fruits and Risk of Breast Cancer. JAMA. 2005 Jan 12;293(2):183-93. PubMed PMID: 15644545.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Consumption of vegetables and fruits and risk of breast cancer. AU - van Gils,Carla H, AU - Peeters,Petra H M, AU - Bueno-de-Mesquita,H Bas, AU - Boshuizen,Hendriek C, AU - Lahmann,Petra H, AU - Clavel-Chapelon,Françoise, AU - Thiébaut,Anne, AU - Kesse,Emmanuelle, AU - Sieri,Sabina, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Vineis,Paolo, AU - Gonzalez,Carlos A, AU - Ardanaz,Eva, AU - Sánchez,Maria-José, AU - Amiano,Pilar, AU - Navarro,Carmen, AU - Quirós,José R, AU - Key,Timothy J, AU - Allen,Naomi, AU - Khaw,Kay-Tee, AU - Bingham,Sheila A, AU - Psaltopoulou,Theodora, AU - Koliva,Maria, AU - Trichopoulou,Antonia, AU - Nagel,Gabriële, AU - Linseisen,Jakob, AU - Boeing,Heiner, AU - Berglund,Göran, AU - Wirfält,Elisabet, AU - Hallmans,Göran, AU - Lenner,Per, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Olsen,Anja, AU - Lund,Eiliv, AU - Engeset,Dagrun, AU - Alsaker,Elin, AU - Norat,Teresa, AU - Kaaks,Rudolf, AU - Slimani,Nadia, AU - Riboli,Elio, PY - 2005/1/13/pubmed PY - 2005/2/3/medline PY - 2005/1/13/entrez SP - 183 EP - 93 JF - JAMA JO - JAMA VL - 293 IS - 2 N2 - CONTEXT: The intake of vegetables and fruits has been thought to protect against breast cancer. Most of the evidence comes from case-control studies, but a recent pooled analysis of the relatively few published cohort studies suggests no significantly reduced breast cancer risk is associated with vegetable and fruit consumption. OBJECTIVE: To examine the relation between total and specific vegetable and fruit intake and the incidence of breast cancer. DESIGN, SETTING, AND PARTICIPANTS: Prospective study of 285,526 women between the ages of 25 and 70 years, participating in the European Prospective Investigation Into Cancer and Nutrition (EPIC) study, recruited from 8 of the 10 participating European countries. Participants completed a dietary questionnaire in 1992-1998 and were followed up for incidence of cancer until 2002. MAIN OUTCOME MEASURES: Relative risks for breast cancer by total and specific vegetable and fruit intake. Analyses were stratified by age at recruitment and study center. Relative risks were adjusted for established breast cancer risk factors. RESULTS: During 1,486,402 person-years (median duration of follow-up, 5.4 years), 3659 invasive incident breast cancer cases were reported. No significant associations between vegetable or fruit intake and breast cancer risk were observed. Relative risks for the highest vs the lowest quintile were 0.98 (95% confidence interval [CI], 0.84-1.14) for total vegetables, 1.09 (95% CI , 0.94-1.25) for total fruit, and 1.05 (95% CI , 0.92-1.20) for fruit and vegetable juices. For 6 specific vegetable subgroups no associations with breast cancer risk were observed either. CONCLUSION: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/15644545/Consumption_of_vegetables_and_fruits_and_risk_of_breast_cancer_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.293.2.183 DB - PRIME DP - Unbound Medicine ER -