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Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol.
Org Lett. 2005 Jan 20; 7(2):187-90.OL

Abstract

[Reaction: see text] Various substituted conjugated dienes have been made by olefin cross-metathesis. Using either electronic or steric "protection," one of the olefins of the conjugated diene was deactivated relative to the other for cross-metathesis. The reactions proceed with very high chemoselectivity and, when steric deactivation is used, very high diastereoselectivity.

Authors+Show Affiliations

Funk TW
Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Efskind J
No affiliation info available
Grubbs RH
No affiliation info available

MeSH

AlkenesCatalysisMolecular StructureOrganometallic CompoundsRutheniumStereoisomerism

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

15646954

Citation

Funk, Timothy W., et al. "Chemoselective Construction of Substituted Conjugated Dienes Using an Olefin Cross-metathesis Protocol." Organic Letters, vol. 7, no. 2, 2005, pp. 187-90.
Funk TW, Efskind J, Grubbs RH. Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol. Org Lett. 2005;7(2):187-90.
Funk, T. W., Efskind, J., & Grubbs, R. H. (2005). Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol. Organic Letters, 7(2), 187-90.
Funk TW, Efskind J, Grubbs RH. Chemoselective Construction of Substituted Conjugated Dienes Using an Olefin Cross-metathesis Protocol. Org Lett. 2005 Jan 20;7(2):187-90. PubMed PMID: 15646954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol. AU - Funk,Timothy W, AU - Efskind,Jon, AU - Grubbs,Robert H, PY - 2005/1/14/pubmed PY - 2006/7/6/medline PY - 2005/1/14/entrez SP - 187 EP - 90 JF - Organic letters JO - Org Lett VL - 7 IS - 2 N2 - [Reaction: see text] Various substituted conjugated dienes have been made by olefin cross-metathesis. Using either electronic or steric "protection," one of the olefins of the conjugated diene was deactivated relative to the other for cross-metathesis. The reactions proceed with very high chemoselectivity and, when steric deactivation is used, very high diastereoselectivity. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/15646954/Chemoselective_construction_of_substituted_conjugated_dienes_using_an_olefin_cross_metathesis_protocol_ DB - PRIME DP - Unbound Medicine ER -