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Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract.
J Clin Pharmacol. 2005 Feb; 45(2):203-10.JC

Abstract

Pharmacokinetic parameters of several dietary anthocyanins following consumption of Hibiscus sabdariffa L. extract were determined in 6 healthy volunteers. Subjects were given a single oral dose of 150 mL of Hibiscus sabdariffa L. extract yielding 62.6 mg of cyanidin-3-sambubioside, 81.6 mg of delphindin-3-sambubioside, and 147.4 mg of total anthocyanins (calculated as cyanidin equivalents). Within 7 hours, the urinary excretion of cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins (ie, the sum of all quantifiable anthocyanidin glycosides) was 0.016%, 0.021%, and 0.018% of the administered doses, respectively. Maximum excretion rates were determined at 1.5 to 2.0 hours after intake. The dose-normalized plasma area under the curve estimates were 0.076, 0.032, and 0.050 ng x h/mL/mg for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The dose-normalized C(max) estimates were 0.036, 0.015, and 0.023 ng/mL/mg in the same sequence. They were reached each at 1.5 hours (median) after intake. The geometric means of t1/2 were 2.18, 3.34, and 2.63 hours for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The urinary excretion of intact anthocyanins was fast and appeared to be monoexponential. To evaluate the contribution of anthocyanins to the health-protecting effects of Hibiscus sabdariffa L. extract, it will be necessary to perform further studies on both the intact glycosides and their in vivo metabolites or conjugates in human plasma and urine.

Authors+Show Affiliations

IMFORM GmbH International Clinical Research, Birkenweg 14, D-64295 Darmstadt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15647413

Citation

Frank, Thomas, et al. "Pharmacokinetics of Anthocyanidin-3-glycosides Following Consumption of Hibiscus Sabdariffa L. Extract." Journal of Clinical Pharmacology, vol. 45, no. 2, 2005, pp. 203-10.
Frank T, Janssen M, Netzel M, et al. Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. J Clin Pharmacol. 2005;45(2):203-10.
Frank, T., Janssen, M., Netzel, M., Strass, G., Kler, A., Kriesl, E., & Bitsch, I. (2005). Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. Journal of Clinical Pharmacology, 45(2), 203-10.
Frank T, et al. Pharmacokinetics of Anthocyanidin-3-glycosides Following Consumption of Hibiscus Sabdariffa L. Extract. J Clin Pharmacol. 2005;45(2):203-10. PubMed PMID: 15647413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. AU - Frank,Thomas, AU - Janssen,Marlies, AU - Netzel,Michael, AU - Strass,Gabriele, AU - Kler,Adolf, AU - Kriesl,Erwin, AU - Bitsch,Irmgard, PY - 2005/1/14/pubmed PY - 2006/1/5/medline PY - 2005/1/14/entrez SP - 203 EP - 10 JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 45 IS - 2 N2 - Pharmacokinetic parameters of several dietary anthocyanins following consumption of Hibiscus sabdariffa L. extract were determined in 6 healthy volunteers. Subjects were given a single oral dose of 150 mL of Hibiscus sabdariffa L. extract yielding 62.6 mg of cyanidin-3-sambubioside, 81.6 mg of delphindin-3-sambubioside, and 147.4 mg of total anthocyanins (calculated as cyanidin equivalents). Within 7 hours, the urinary excretion of cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins (ie, the sum of all quantifiable anthocyanidin glycosides) was 0.016%, 0.021%, and 0.018% of the administered doses, respectively. Maximum excretion rates were determined at 1.5 to 2.0 hours after intake. The dose-normalized plasma area under the curve estimates were 0.076, 0.032, and 0.050 ng x h/mL/mg for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The dose-normalized C(max) estimates were 0.036, 0.015, and 0.023 ng/mL/mg in the same sequence. They were reached each at 1.5 hours (median) after intake. The geometric means of t1/2 were 2.18, 3.34, and 2.63 hours for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The urinary excretion of intact anthocyanins was fast and appeared to be monoexponential. To evaluate the contribution of anthocyanins to the health-protecting effects of Hibiscus sabdariffa L. extract, it will be necessary to perform further studies on both the intact glycosides and their in vivo metabolites or conjugates in human plasma and urine. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/15647413/Pharmacokinetics_of_anthocyanidin_3_glycosides_following_consumption_of_Hibiscus_sabdariffa_L__extract_ L2 - https://doi.org/10.1177/0091270004270561 DB - PRIME DP - Unbound Medicine ER -