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Association of apolipoprotein E genotypes with serum lipid profiles in a healthy population of Taiwan.
Ann Clin Lab Sci. 2004 Autumn; 34(4):443-8.AC

Abstract

Apolipoprotein E (apoE, protein; APOE, gene) plays a major role in lipoprotein metabolism and lipid transport. Many investigators have described associations between apoE genotypes, coronary artery disease (CAD), and other risk factors. The aim of this study was to investigate the association between apoE genotypes and serum lipid profiles in a healthy population of 220 volunteers at Kaohsiung in Taiwan. Other CAD risk factors such as serum levels of apolipoprotein A-I (apoA-I), apolipoprotein B, (apoB), homocysteine (Hcy), folate, and vitamin B12 were also measured. ApoE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In the study population, the frequency of apoE allele epsilon3 was greatest (85.2%); the frequency of epsilon2 was 8.4%; and that of epsilon4 was 6.4%. The serum apoA-1/apoB ratio showed significant difference among the 3 apoE genotype groups (p 0.0001); the apoA-1/apoB ratio was 1.9 +/- 0.1 (mean +/- SD) in the epsilon2 group, vs 1.4 +/- 0.04 and 1.5 +/- 0.12 in the epsilon3 and epsilon4 groups, respectively. No significant associations were found between APOE alleles and the serum levels of the various lipids or other CHD risk factors.

Authors+Show Affiliations

Department of Clinical Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15648787

Citation

Lin, Shu-Kai, et al. "Association of Apolipoprotein E Genotypes With Serum Lipid Profiles in a Healthy Population of Taiwan." Annals of Clinical and Laboratory Science, vol. 34, no. 4, 2004, pp. 443-8.
Lin SK, Kao JT, Tsai SM, et al. Association of apolipoprotein E genotypes with serum lipid profiles in a healthy population of Taiwan. Ann Clin Lab Sci. 2004;34(4):443-8.
Lin, S. K., Kao, J. T., Tsai, S. M., Tsai, L. Y., Lin, M. N., Lai, C. J., & Zhong, W. L. (2004). Association of apolipoprotein E genotypes with serum lipid profiles in a healthy population of Taiwan. Annals of Clinical and Laboratory Science, 34(4), 443-8.
Lin SK, et al. Association of Apolipoprotein E Genotypes With Serum Lipid Profiles in a Healthy Population of Taiwan. Ann Clin Lab Sci. 2004;34(4):443-8. PubMed PMID: 15648787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of apolipoprotein E genotypes with serum lipid profiles in a healthy population of Taiwan. AU - Lin,Shu-Kai, AU - Kao,Jau-Tsuen, AU - Tsai,Shih-Meng, AU - Tsai,Li-Yu, AU - Lin,Mei-Nung, AU - Lai,Chung-Jen, AU - Zhong,Way-Li, PY - 2005/1/15/pubmed PY - 2005/4/29/medline PY - 2005/1/15/entrez SP - 443 EP - 8 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 34 IS - 4 N2 - Apolipoprotein E (apoE, protein; APOE, gene) plays a major role in lipoprotein metabolism and lipid transport. Many investigators have described associations between apoE genotypes, coronary artery disease (CAD), and other risk factors. The aim of this study was to investigate the association between apoE genotypes and serum lipid profiles in a healthy population of 220 volunteers at Kaohsiung in Taiwan. Other CAD risk factors such as serum levels of apolipoprotein A-I (apoA-I), apolipoprotein B, (apoB), homocysteine (Hcy), folate, and vitamin B12 were also measured. ApoE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In the study population, the frequency of apoE allele epsilon3 was greatest (85.2%); the frequency of epsilon2 was 8.4%; and that of epsilon4 was 6.4%. The serum apoA-1/apoB ratio showed significant difference among the 3 apoE genotype groups (p 0.0001); the apoA-1/apoB ratio was 1.9 +/- 0.1 (mean +/- SD) in the epsilon2 group, vs 1.4 +/- 0.04 and 1.5 +/- 0.12 in the epsilon3 and epsilon4 groups, respectively. No significant associations were found between APOE alleles and the serum levels of the various lipids or other CHD risk factors. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/15648787/Association_of_apolipoprotein_E_genotypes_with_serum_lipid_profiles_in_a_healthy_population_of_Taiwan_ L2 - http://www.annclinlabsci.org/cgi/pmidlookup?view=long&pmid=15648787 DB - PRIME DP - Unbound Medicine ER -