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Report of two cases: Rattlesnake venom-induced thrombocytopenia.
Ann Clin Lab Sci. 2004 Autumn; 34(4):467-70.AC

Abstract

We report 2 patients who presented with vasomotor symptoms and severe thrombocytopenia following rattlesnake bites. These symptoms persisted in spite of treatment with antivenin and transfusion of multiple doses of platelets. Thrombocytopenia is a common occurrence in moderate to severe crotaline envenomation. Algorithms suggested for the treatment of rattlesnake envenomation with crotaline-specific antivenin may not reverse the associated thrombocytopenia. The precise mechanism of venom-induced thrombocytopenia (VIT), even in the absence of significant coagulopathy, is unknown. Our experience suggests that, unless spontaneous bleeding occurs, repeated transfusion of fresh frozen plasma and/or platelets may not be indicated.

Authors+Show Affiliations

Odeleye AA
Department of Pathology, University of Virginia Heath System, Charlottesville, Virginia 22908, USA.
Presley AE
No affiliation info available
Passwater ME
No affiliation info available
Mintz PD
No affiliation info available

MeSH

AdultAnimalsAntiveninsCrotalid VenomsCrotalusHumansImmunoglobulin Fab FragmentsImmunoglobulin FragmentsMalePlatelet TransfusionSnake BitesThrombocytopenia

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15648790

Citation

Odeleye, Abiodun A., et al. "Report of Two Cases: Rattlesnake Venom-induced Thrombocytopenia." Annals of Clinical and Laboratory Science, vol. 34, no. 4, 2004, pp. 467-70.
Odeleye AA, Presley AE, Passwater ME, et al. Report of two cases: Rattlesnake venom-induced thrombocytopenia. Ann Clin Lab Sci. 2004;34(4):467-70.
Odeleye, A. A., Presley, A. E., Passwater, M. E., & Mintz, P. D. (2004). Report of two cases: Rattlesnake venom-induced thrombocytopenia. Annals of Clinical and Laboratory Science, 34(4), 467-70.
Odeleye AA, et al. Report of Two Cases: Rattlesnake Venom-induced Thrombocytopenia. Ann Clin Lab Sci. 2004;34(4):467-70. PubMed PMID: 15648790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Report of two cases: Rattlesnake venom-induced thrombocytopenia. AU - Odeleye,Abiodun A, AU - Presley,Ali E, AU - Passwater,Michael E, AU - Mintz,Paul D, PY - 2005/1/15/pubmed PY - 2005/4/29/medline PY - 2005/1/15/entrez SP - 467 EP - 70 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 34 IS - 4 N2 - We report 2 patients who presented with vasomotor symptoms and severe thrombocytopenia following rattlesnake bites. These symptoms persisted in spite of treatment with antivenin and transfusion of multiple doses of platelets. Thrombocytopenia is a common occurrence in moderate to severe crotaline envenomation. Algorithms suggested for the treatment of rattlesnake envenomation with crotaline-specific antivenin may not reverse the associated thrombocytopenia. The precise mechanism of venom-induced thrombocytopenia (VIT), even in the absence of significant coagulopathy, is unknown. Our experience suggests that, unless spontaneous bleeding occurs, repeated transfusion of fresh frozen plasma and/or platelets may not be indicated. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/15648790/Report_of_two_cases:_Rattlesnake_venom_induced_thrombocytopenia_ DB - PRIME DP - Unbound Medicine ER -