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Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.
Neurobiol Dis. 2005 Feb; 18(1):134-42.ND

Abstract

The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. When young transgenic mice were transplanted before the onset of AD-like pathology and the brains analyzed 6.5 months later, the number of engrafted cells was significantly higher than in age-matched wild type mice. Moreover, the number of BM-derived cells associated with Abeta was significantly higher than in old transgenic mice transplanted after the establishment of AD-like pathology. Local inflammation caused by intrahippocampal lipopolysaccharide injection significantly increased the engraftment of BM-derived cells in old AD mice and decreased the hippocampal Abeta burden. These results suggest that infiltration of BM-derived monocytic cells into the brain contributes to the development of microglial reaction in AD.

Authors+Show Affiliations

Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15649704

Citation

Malm, Tarja M., et al. "Bone-marrow-derived Cells Contribute to the Recruitment of Microglial Cells in Response to Beta-amyloid Deposition in APP/PS1 Double Transgenic Alzheimer Mice." Neurobiology of Disease, vol. 18, no. 1, 2005, pp. 134-42.
Malm TM, Koistinaho M, Pärepalo M, et al. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiol Dis. 2005;18(1):134-42.
Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005). Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiology of Disease, 18(1), 134-42.
Malm TM, et al. Bone-marrow-derived Cells Contribute to the Recruitment of Microglial Cells in Response to Beta-amyloid Deposition in APP/PS1 Double Transgenic Alzheimer Mice. Neurobiol Dis. 2005;18(1):134-42. PubMed PMID: 15649704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. AU - Malm,Tarja M, AU - Koistinaho,Milla, AU - Pärepalo,Maria, AU - Vatanen,Tero, AU - Ooka,Andreas, AU - Karlsson,Stefan, AU - Koistinaho,Jari, PY - 2004/07/14/received PY - 2004/09/06/revised PY - 2004/09/13/accepted PY - 2005/1/15/pubmed PY - 2005/5/17/medline PY - 2005/1/15/entrez SP - 134 EP - 42 JF - Neurobiology of disease JO - Neurobiol Dis VL - 18 IS - 1 N2 - The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derived cells into the brain and their relative distribution near Abeta deposits. When young transgenic mice were transplanted before the onset of AD-like pathology and the brains analyzed 6.5 months later, the number of engrafted cells was significantly higher than in age-matched wild type mice. Moreover, the number of BM-derived cells associated with Abeta was significantly higher than in old transgenic mice transplanted after the establishment of AD-like pathology. Local inflammation caused by intrahippocampal lipopolysaccharide injection significantly increased the engraftment of BM-derived cells in old AD mice and decreased the hippocampal Abeta burden. These results suggest that infiltration of BM-derived monocytic cells into the brain contributes to the development of microglial reaction in AD. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/15649704/Bone_marrow_derived_cells_contribute_to_the_recruitment_of_microglial_cells_in_response_to_beta_amyloid_deposition_in_APP/PS1_double_transgenic_Alzheimer_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(04)00218-9 DB - PRIME DP - Unbound Medicine ER -