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Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease.
FASEB J. 2005 Apr; 19(6):659-61.FJ

Abstract

This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Abeta peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology.

Authors+Show Affiliations

Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15650008

Citation

Wang, Jun, et al. "Caloric Restriction Attenuates Beta-amyloid Neuropathology in a Mouse Model of Alzheimer's Disease." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 19, no. 6, 2005, pp. 659-61.
Wang J, Ho L, Qin W, et al. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2005;19(6):659-61.
Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K., Dolios, G., Wang, R., Hof, P. R., & Pasinetti, G. M. (2005). Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 19(6), 659-61.
Wang J, et al. Caloric Restriction Attenuates Beta-amyloid Neuropathology in a Mouse Model of Alzheimer's Disease. FASEB J. 2005;19(6):659-61. PubMed PMID: 15650008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. AU - Wang,Jun, AU - Ho,Lap, AU - Qin,Weiping, AU - Rocher,Anne B, AU - Seror,Ilana, AU - Humala,Nelson, AU - Maniar,Kruti, AU - Dolios,Georgia, AU - Wang,Rong, AU - Hof,Patrick R, AU - Pasinetti,Giulio Maria, Y1 - 2005/01/13/ PY - 2005/1/15/pubmed PY - 2005/12/15/medline PY - 2005/1/15/entrez SP - 659 EP - 61 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J. VL - 19 IS - 6 N2 - This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal to the initiation and progression of the disease. We report that a CR dietary regimen prevents Abeta peptides generation and neuritic plaque deposition in the brain of a mouse model of AD neuropathology through mechanisms associated with promotion of anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating that caloric intake may influence risk for AD and raises the possibility that CR may be used in preventative measures aimed at delaying the onset of AD amyloid neuropathology. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/15650008/Caloric_restriction_attenuates_beta_amyloid_neuropathology_in_a_mouse_model_of_Alzheimer's_disease_ L2 - http://www.fasebj.org/doi/full/10.1096/fj.04-3182fje?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -