Tags

Type your tag names separated by a space and hit enter

Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons.
J Pharmacol Exp Ther. 2005 Apr; 313(1):134-45.JP

Abstract

The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine (DA) system. The present study assessed whether adult female Wistar rats would self-administer cocaine directly into the ventral tegmental area (VTA). Following guide cannulae surgery aimed at either the posterior or anterior VTA, subjects were placed in an operant box equipped with an active lever that caused the delivery of the infusate and an inactive lever that did not. Posterior and anterior VTA subjects were randomly assigned to one of six groups that self-administered either artificial cerebrospinal fluid (aCSF) or 25 to 400 pmol cocaine/100 nl in aCSF for the first four sessions, aCSF in sessions 5 and 6, and the acquisition dose of infusate during session 7. Additionally, the effects of increasing the time-out period, higher concentrations of cocaine, coadministration of a 5HT3 antagonist, and coadministration of a D2/3 agonist on self-infusion of cocaine were determined. Self-infusions were maintained when the time-out period was extended from 5 to 25 s. Coinfusion of a 5HT3 antagonist or D2/3 agonist blocked the self-infusion of cocaine. In contrast, rats did not self-administer 25 to 400 pmol/100 nl cocaine into the anterior VTA. Additionally, rats did not self-administer either 800 or 1600 pmol/100 nl cocaine into the posterior or anterior VTA. Overall, the data indicate that the VTA is functionally heterogeneous with regard to the rewarding actions of cocaine and that the reinforcing effects of cocaine within the posterior VTA are mediated by activation 5-HT3 receptors and DA neurons.

Authors+Show Affiliations

Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202-4887, USA. zrodd@iupui.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15650115

Citation

Rodd, Zachary A., et al. "Intracranial Self-administration of Cocaine Within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons." The Journal of Pharmacology and Experimental Therapeutics, vol. 313, no. 1, 2005, pp. 134-45.
Rodd ZA, Bell RL, Kuc KA, et al. Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons. J Pharmacol Exp Ther. 2005;313(1):134-45.
Rodd, Z. A., Bell, R. L., Kuc, K. A., Zhang, Y., Murphy, J. M., & McBride, W. J. (2005). Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons. The Journal of Pharmacology and Experimental Therapeutics, 313(1), 134-45.
Rodd ZA, et al. Intracranial Self-administration of Cocaine Within the Posterior Ventral Tegmental Area of Wistar Rats: Evidence for Involvement of Serotonin-3 Receptors and Dopamine Neurons. J Pharmacol Exp Ther. 2005;313(1):134-45. PubMed PMID: 15650115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons. AU - Rodd,Zachary A, AU - Bell,Richard L, AU - Kuc,Kelly A, AU - Zhang,Ying, AU - Murphy,James M, AU - McBride,William J, Y1 - 2005/01/13/ PY - 2005/1/15/pubmed PY - 2005/5/20/medline PY - 2005/1/15/entrez SP - 134 EP - 45 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 313 IS - 1 N2 - The rewarding properties of cocaine have been postulated to be regulated, in part, by the mesolimbic dopamine (DA) system. The present study assessed whether adult female Wistar rats would self-administer cocaine directly into the ventral tegmental area (VTA). Following guide cannulae surgery aimed at either the posterior or anterior VTA, subjects were placed in an operant box equipped with an active lever that caused the delivery of the infusate and an inactive lever that did not. Posterior and anterior VTA subjects were randomly assigned to one of six groups that self-administered either artificial cerebrospinal fluid (aCSF) or 25 to 400 pmol cocaine/100 nl in aCSF for the first four sessions, aCSF in sessions 5 and 6, and the acquisition dose of infusate during session 7. Additionally, the effects of increasing the time-out period, higher concentrations of cocaine, coadministration of a 5HT3 antagonist, and coadministration of a D2/3 agonist on self-infusion of cocaine were determined. Self-infusions were maintained when the time-out period was extended from 5 to 25 s. Coinfusion of a 5HT3 antagonist or D2/3 agonist blocked the self-infusion of cocaine. In contrast, rats did not self-administer 25 to 400 pmol/100 nl cocaine into the anterior VTA. Additionally, rats did not self-administer either 800 or 1600 pmol/100 nl cocaine into the posterior or anterior VTA. Overall, the data indicate that the VTA is functionally heterogeneous with regard to the rewarding actions of cocaine and that the reinforcing effects of cocaine within the posterior VTA are mediated by activation 5-HT3 receptors and DA neurons. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/15650115/Intracranial_self_administration_of_cocaine_within_the_posterior_ventral_tegmental_area_of_Wistar_rats:_evidence_for_involvement_of_serotonin_3_receptors_and_dopamine_neurons_ DB - PRIME DP - Unbound Medicine ER -