Tags

Type your tag names separated by a space and hit enter

Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome.
Diabetes Metab Res Rev 2005 Sep-Oct; 21(5):434-40DM

Abstract

BACKGROUND AND AIM

Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance.

METHODS

Eye examinations, including IOP measurement, were conducted on 943 subjects (533 men and 410 women). Body mass index (BMI), percent body fat, waist circumference, systolic and diastolic pressure, fasting insulin, glucose, lipids, and other metabolic parameters were measured. The homeostasis model assessment (HOMA) score and McAuley index were calculated to assess whole-body insulin resistance.

RESULTS

Both of these insulin resistance indices showed positive associations with IOP (p < 0.05), even after statistical adjustment for other risk factors. IOP was higher in participants with metabolic syndrome, as compared to those who did not have metabolic syndrome. The mean IOP tended to increase linearly with the presence of increasing numbers of components for metabolic syndrome.

CONCLUSIONS

These results suggest that insulin resistance might contribute to an explanation that would account for many previous findings concerning the association between IOP and obesity, hypertension, and diabetes.

Authors+Show Affiliations

Department of Family Medicine and Center for Health Promotion, Ilsan-paik Hospital, Inje University, College of Medicine, Gyeonggi-Do, South Korea. osw6021@yahoo.co.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15651065

Citation

Oh, Sang Woo, et al. "Elevated Intraocular Pressure Is Associated With Insulin Resistance and Metabolic Syndrome." Diabetes/metabolism Research and Reviews, vol. 21, no. 5, 2005, pp. 434-40.
Oh SW, Lee S, Park C, et al. Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. Diabetes Metab Res Rev. 2005;21(5):434-40.
Oh, S. W., Lee, S., Park, C., & Kim, D. J. (2005). Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. Diabetes/metabolism Research and Reviews, 21(5), pp. 434-40.
Oh SW, et al. Elevated Intraocular Pressure Is Associated With Insulin Resistance and Metabolic Syndrome. Diabetes Metab Res Rev. 2005;21(5):434-40. PubMed PMID: 15651065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. AU - Oh,Sang Woo, AU - Lee,Sangyeoup, AU - Park,Cheolyoung, AU - Kim,Dong Jun, PY - 2005/1/15/pubmed PY - 2005/10/22/medline PY - 2005/1/15/entrez SP - 434 EP - 40 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 21 IS - 5 N2 - BACKGROUND AND AIM: Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance. METHODS: Eye examinations, including IOP measurement, were conducted on 943 subjects (533 men and 410 women). Body mass index (BMI), percent body fat, waist circumference, systolic and diastolic pressure, fasting insulin, glucose, lipids, and other metabolic parameters were measured. The homeostasis model assessment (HOMA) score and McAuley index were calculated to assess whole-body insulin resistance. RESULTS: Both of these insulin resistance indices showed positive associations with IOP (p < 0.05), even after statistical adjustment for other risk factors. IOP was higher in participants with metabolic syndrome, as compared to those who did not have metabolic syndrome. The mean IOP tended to increase linearly with the presence of increasing numbers of components for metabolic syndrome. CONCLUSIONS: These results suggest that insulin resistance might contribute to an explanation that would account for many previous findings concerning the association between IOP and obesity, hypertension, and diabetes. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/15651065/full_citation L2 - https://doi.org/10.1002/dmrr.529 DB - PRIME DP - Unbound Medicine ER -