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Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome.

Abstract

BACKGROUND AND AIM

Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance.

METHODS

Eye examinations, including IOP measurement, were conducted on 943 subjects (533 men and 410 women). Body mass index (BMI), percent body fat, waist circumference, systolic and diastolic pressure, fasting insulin, glucose, lipids, and other metabolic parameters were measured. The homeostasis model assessment (HOMA) score and McAuley index were calculated to assess whole-body insulin resistance.

RESULTS

Both of these insulin resistance indices showed positive associations with IOP (p < 0.05), even after statistical adjustment for other risk factors. IOP was higher in participants with metabolic syndrome, as compared to those who did not have metabolic syndrome. The mean IOP tended to increase linearly with the presence of increasing numbers of components for metabolic syndrome.

CONCLUSIONS

These results suggest that insulin resistance might contribute to an explanation that would account for many previous findings concerning the association between IOP and obesity, hypertension, and diabetes.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Family Medicine and Center for Health Promotion, Ilsan-paik Hospital, Inje University, College of Medicine, Gyeonggi-Do, South Korea. osw6021@yahoo.co.kr

    , ,

    Source

    MeSH

    Abdomen
    Adult
    Blood Glucose
    Blood Pressure
    Body Composition
    Body Mass Index
    Cholesterol, HDL
    Cholesterol, LDL
    Fasting
    Female
    Humans
    Insulin Resistance
    Intraocular Pressure
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15651065

    Citation

    Oh, Sang Woo, et al. "Elevated Intraocular Pressure Is Associated With Insulin Resistance and Metabolic Syndrome." Diabetes/metabolism Research and Reviews, vol. 21, no. 5, 2005, pp. 434-40.
    Oh SW, Lee S, Park C, et al. Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. Diabetes Metab Res Rev. 2005;21(5):434-40.
    Oh, S. W., Lee, S., Park, C., & Kim, D. J. (2005). Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. Diabetes/metabolism Research and Reviews, 21(5), pp. 434-40.
    Oh SW, et al. Elevated Intraocular Pressure Is Associated With Insulin Resistance and Metabolic Syndrome. Diabetes Metab Res Rev. 2005;21(5):434-40. PubMed PMID: 15651065.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome. AU - Oh,Sang Woo, AU - Lee,Sangyeoup, AU - Park,Cheolyoung, AU - Kim,Dong Jun, PY - 2005/1/15/pubmed PY - 2005/10/22/medline PY - 2005/1/15/entrez SP - 434 EP - 40 JF - Diabetes/metabolism research and reviews JO - Diabetes Metab. Res. Rev. VL - 21 IS - 5 N2 - BACKGROUND AND AIM: Elevated intraocular pressure (IOP), a well-known risk factor for glaucoma, has recently been shown to be associated with some metabolic complications and obesity. We investigated the link between IOP and metabolic disturbances, focusing especially on metabolic syndrome and insulin resistance. METHODS: Eye examinations, including IOP measurement, were conducted on 943 subjects (533 men and 410 women). Body mass index (BMI), percent body fat, waist circumference, systolic and diastolic pressure, fasting insulin, glucose, lipids, and other metabolic parameters were measured. The homeostasis model assessment (HOMA) score and McAuley index were calculated to assess whole-body insulin resistance. RESULTS: Both of these insulin resistance indices showed positive associations with IOP (p < 0.05), even after statistical adjustment for other risk factors. IOP was higher in participants with metabolic syndrome, as compared to those who did not have metabolic syndrome. The mean IOP tended to increase linearly with the presence of increasing numbers of components for metabolic syndrome. CONCLUSIONS: These results suggest that insulin resistance might contribute to an explanation that would account for many previous findings concerning the association between IOP and obesity, hypertension, and diabetes. SN - 1520-7552 UR - https://www.unboundmedicine.com/medline/citation/15651065/full_citation L2 - https://doi.org/10.1002/dmrr.529 DB - PRIME DP - Unbound Medicine ER -