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[The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration].
Rinsho Shinkeigaku. 2004 Nov; 44(11):821-3.RS

Abstract

In the majority of patients with Parkinson's disease (PD), it is now clear that genetic factors contribute to the pathogenesis of PD, although the contribution of genetic and environmental factors remained to be elucidated. Recently, several genes for familial PD (FPD) based on the single gene defects have been mapped and identified. Alpha-synuclein and UCH-L1 are involved in the dominant form of FPD. In contrast, parkin, DJ-1, and PINK1 are responsible for the recessive form of FPD. The presence of different loci or different causative genes indicates that PD is not a single entity but a highly heterogeneous disorder. However, the functions of causative genes may share common pathways such as an ubiquitin-proteasome pathway, oxidative stress, and mitochondrial dysfunction. Thus, the identification and elucidation of the causative genes should enhance our understanding of the pathogenesis of not only FPD, but also sporadic PD.

Authors+Show Affiliations

Department of Neurology, Juntendo University School of Medicine.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

15651302

Citation

Hattori, Nobutaka. "[The Gene Products for Familial Parkinson's Disease Provide Us Hints to Elucidate the Mechanisms of Nigral Degeneration]." Rinsho Shinkeigaku = Clinical Neurology, vol. 44, no. 11, 2004, pp. 821-3.
Hattori N. [The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration]. Rinsho Shinkeigaku. 2004;44(11):821-3.
Hattori, N. (2004). [The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration]. Rinsho Shinkeigaku = Clinical Neurology, 44(11), 821-3.
Hattori N. [The Gene Products for Familial Parkinson's Disease Provide Us Hints to Elucidate the Mechanisms of Nigral Degeneration]. Rinsho Shinkeigaku. 2004;44(11):821-3. PubMed PMID: 15651302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The gene products for familial Parkinson's disease provide us hints to elucidate the mechanisms of nigral degeneration]. A1 - Hattori,Nobutaka, PY - 2005/1/18/pubmed PY - 2005/3/5/medline PY - 2005/1/18/entrez SP - 821 EP - 3 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 44 IS - 11 N2 - In the majority of patients with Parkinson's disease (PD), it is now clear that genetic factors contribute to the pathogenesis of PD, although the contribution of genetic and environmental factors remained to be elucidated. Recently, several genes for familial PD (FPD) based on the single gene defects have been mapped and identified. Alpha-synuclein and UCH-L1 are involved in the dominant form of FPD. In contrast, parkin, DJ-1, and PINK1 are responsible for the recessive form of FPD. The presence of different loci or different causative genes indicates that PD is not a single entity but a highly heterogeneous disorder. However, the functions of causative genes may share common pathways such as an ubiquitin-proteasome pathway, oxidative stress, and mitochondrial dysfunction. Thus, the identification and elucidation of the causative genes should enhance our understanding of the pathogenesis of not only FPD, but also sporadic PD. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/15651302/[The_gene_products_for_familial_Parkinson's_disease_provide_us_hints_to_elucidate_the_mechanisms_of_nigral_degeneration]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -
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