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Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum.
J Ethnopharmacol. 2005 Feb 10; 97(1):73-7.JE

Abstract

Mate is a xanthine-containing beverage, which is prepared as an infusion of the dried and ground leaves of Ilex paraguariensis St. Hil. (Aquifoliacea). Previous reports have shown that Ilex paraguariensis has the highest levels of caffeine and theobromine when compared to other Ilex species. Furthermore, mate is able to interfere in the circulatory system, acting as a diuretic and hypotensive agent. Many processes of vascular injury result in the release of adenine nucleotides, which exert a variety of effects. Nucleoside 5' tri- and diphosphates may be hydrolyzed by members of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The synchronic action of a NTPDase and a 5'-nucleotidase promotes the catabolism of ATP to adenosine, which is able to control the extracellular nucleotides/nucleosides ratio. The chronic ingestion of aqueous extract of Ilex paraguariensis by rats during 15 days significantly decreased ATP (55%), ADP (50%) and AMP (40%) hydrolysis in blood serum. These results suggest changes in the balance of purine levels induced by Ilex paraguariensis ingestion. Considering the potential effects of Ilex paraguariensis in the circulatory system, these results may be relevant since NTPDases are a novel drug target for the treatment of cardiovascular diseases.

Authors+Show Affiliations

Laboratório de Bioquímica, UNIVATES Centro Universitário, Lajeado, Rua Avelino Tallini, 171 CEP: 95900-000 Caixa Posta 155, Lajeado, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15652278

Citation

Görgen, Milena, et al. "Aqueous Extract of Ilex Paraguariensis Decreases Nucleotide Hydrolysis in Rat Blood Serum." Journal of Ethnopharmacology, vol. 97, no. 1, 2005, pp. 73-7.
Görgen M, Turatti K, Medeiros AR, et al. Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum. J Ethnopharmacol. 2005;97(1):73-7.
Görgen, M., Turatti, K., Medeiros, A. R., Buffon, A., Bonan, C. D., Sarkis, J. J., & Pereira, G. S. (2005). Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum. Journal of Ethnopharmacology, 97(1), 73-7.
Görgen M, et al. Aqueous Extract of Ilex Paraguariensis Decreases Nucleotide Hydrolysis in Rat Blood Serum. J Ethnopharmacol. 2005 Feb 10;97(1):73-7. PubMed PMID: 15652278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum. AU - Görgen,Milena, AU - Turatti,Kátia, AU - Medeiros,Afonso R, AU - Buffon,Andréia, AU - Bonan,Carla D, AU - Sarkis,João J F, AU - Pereira,Grace S, Y1 - 2004/12/22/ PY - 2004/02/10/received PY - 2004/09/24/revised PY - 2004/10/18/accepted PY - 2005/1/18/pubmed PY - 2005/5/27/medline PY - 2005/1/18/entrez SP - 73 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 97 IS - 1 N2 - Mate is a xanthine-containing beverage, which is prepared as an infusion of the dried and ground leaves of Ilex paraguariensis St. Hil. (Aquifoliacea). Previous reports have shown that Ilex paraguariensis has the highest levels of caffeine and theobromine when compared to other Ilex species. Furthermore, mate is able to interfere in the circulatory system, acting as a diuretic and hypotensive agent. Many processes of vascular injury result in the release of adenine nucleotides, which exert a variety of effects. Nucleoside 5' tri- and diphosphates may be hydrolyzed by members of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The synchronic action of a NTPDase and a 5'-nucleotidase promotes the catabolism of ATP to adenosine, which is able to control the extracellular nucleotides/nucleosides ratio. The chronic ingestion of aqueous extract of Ilex paraguariensis by rats during 15 days significantly decreased ATP (55%), ADP (50%) and AMP (40%) hydrolysis in blood serum. These results suggest changes in the balance of purine levels induced by Ilex paraguariensis ingestion. Considering the potential effects of Ilex paraguariensis in the circulatory system, these results may be relevant since NTPDases are a novel drug target for the treatment of cardiovascular diseases. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15652278/Aqueous_extract_of_Ilex_paraguariensis_decreases_nucleotide_hydrolysis_in_rat_blood_serum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(04)00526-4 DB - PRIME DP - Unbound Medicine ER -